The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery

Goncu, Beyza; Idiz, Ufuk Oguz; Gurol, Ali Osman; aysan, erhan; özdemir, burcu; Yucesan, Emrah

doi:10.4274/imj.galenos.2021.67984

The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery

Ufuk Oğuz İDİZ, (İstanbul Üniversitesi, Aziz Sancar Deneysel Tıp Araştırma Enstitüsü, İmmünoloji Anabilim Dalı, İstanbul, Türkiye)

Emrah YÜCESAN, (Bezmiâlem Vakıf Üniversitesi, Yaşam Bilimleri ve Biyoteknoloji Enstitüsü, İstanbul, Türkiye)

Beyza GÖNCÜ, (Bezmiâlem Vakıf Üniversitesi, Araştırma Merkezi, İstanbul, Türkiye)

Burcu ÖZDEMİR, (Bezmiâlem Vakıf Üniversitesi, Araştırma Merkezi, İstanbul, Türkiye)

Mustafa AYŞAN, (Yeditepe Üniversitesi, Tıp Fakültesi, Genel Cerrahi Anabilim Dalı, İstanbul, Türkiye)

Ali Osman GUROL (İstanbul Üniversitesi, Aziz Sancar Deneysel Tıp Araştırma Enstitüsü, İmmünoloji Anabilim Dalı, İstanbul, Türkiye)

İstanbul Medical Journal

5 0

Yıl: 2021 Cilt: 22 Sayı: 4 Sayfa Aralığı: 275 - 279 Metin Dili: İngilizce DOI: 10.4274/imj.galenos.2021.67984 İndeks Tarihi: 22-05-2022

The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery

Öz:

Introduction: Severe hypocalcemia is a rare but serious complication of secondary hyperparathyroidism (SH) surgery. Continuous intravenous calcium replacement is required and patients are not discharged. Cryopreserved parathyroid autotransplantation (CPA) is the most effective and lasting treatment option for severe hypocalcemia. However, a cryopreservation laboratory is necessary for this procedure. Methods: Subtotal parathyroidectomy performed 150 SH cases (age range: 26-69 years, mean age: 39.5 years, men/women: 2/1) were retrospectively evaluated. Severe hypocalcemia (serum calcium level of ˂6.5 mg/dL) was developed in 7 (4.6%) cases. CPA was performed and cases were observed in a minimum of 18 months. Results: After transplantation in five cases, intravenous and oral calcium replacement was ceased and cases were discharged. Transplantation failed in two cases, thus second time CPA. After the second CPA, intravenous calcium is ceased and cases were discharged. Any side effects or complications were not seen during the observation period. Conclusion: CPA is the most effective and lasting treatment option for severe hypocalcemia. CPA is not difficult to perform but a cryopreservation laboratory and experienced laboratory team are necessary for this procedure. The presence of this laboratory in SH surgery performed centers reduces the risk of mortality and morbidity.

Anahtar Kelime:

Sekonder Hiperparatiroidi Cerrahisi Sonrasında Gelişen Hipoparatiroidinin Tedavisinde Dondurularak Saklanan Paratiroid Dokularının Ototransplantasyonunun Önemi

Öz:

Amaç: Şiddetli hipokalsemi, sekonder hiperparatiroidizm (SH) cerrahisinin nadir fakat ciddi bir komplikasyonudur. Sürekli intravenöz kalsiyum replasmanı gerekebilir ve hastalar hastaneden taburcu edilemez hale gelebilir. Dondurularak saklanmış paratiroid dokusunun ototransplantasyonu, şiddetli hipokalsemi için en etkili ve kalıcı tedavi seçeneğidir. Ancak bu işlem için kriyoprezervasyon laboratuvarı gerekebilir. Yöntemler: Subtotal paratiroidektomi yapılan 150 SH olgusu (yaş aralığı: 26-69, ortalama yaş: 39,5, erkek/kadın: 2/1) retrospektif olarak değerlendirildi. Yedi (%4,6) olguda şiddetli hipokalsemi (serum kalsiyum düzeyi ˂6,5 mg/ dL) gelişti. Bu olgulara dondurularak saklanmış paratiroid dokusunun ototransplantasyonu yapılmış ve olgular en az 18 ay gözlemlenmiştir. Bulgular: Beş hasta transplantasyon sonrası intravenöz ve oral kalsiyum replasmanı kesilerek taburcu edildi. İki olguda ise transplantasyon başarısız oldu ve onlara ikinci kez paratiroid ototransplantasyonu uygulandı. İkinci transplantasyon sonrası intravenöz kalsiyum kesilerek hastalar taburcu edildi. Hiçbir olguda 18 aylık gözlem süresinde herhangi bir yan etki veya komplikasyon görülmedi. Sonuç: Dondurularak saklanmış paratiroid dokusunun ototransplantasyonu, şiddetli hipokalsemi için en etkili ve kalıcı tedavi seçeneğidir. Bu transplantasyonu yapmak zor değildir ancak bu işlem için kriyoprezervasyon laboratuvarı ve deneyimli laboratuvar ekibi gereklidir. SH cerrahisi yapılan merkezlerde bu laboratuvarın bulunması mortalite ve morbidite riskini azaltmaktadır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Idiz U, Yucesan E, Goncu B, özdemir b, aysan e, Gurol A (2021). The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery. , 275 - 279. 10.4274/imj.galenos.2021.67984
Chicago	Idiz Ufuk Oguz,Yucesan Emrah,Goncu Beyza,özdemir burcu,aysan erhan,Gurol Ali Osman The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery. (2021): 275 - 279. 10.4274/imj.galenos.2021.67984
MLA	Idiz Ufuk Oguz,Yucesan Emrah,Goncu Beyza,özdemir burcu,aysan erhan,Gurol Ali Osman The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery. , 2021, ss.275 - 279. 10.4274/imj.galenos.2021.67984
AMA	Idiz U,Yucesan E,Goncu B,özdemir b,aysan e,Gurol A The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery. . 2021; 275 - 279. 10.4274/imj.galenos.2021.67984
Vancouver	Idiz U,Yucesan E,Goncu B,özdemir b,aysan e,Gurol A The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery. . 2021; 275 - 279. 10.4274/imj.galenos.2021.67984
IEEE	Idiz U,Yucesan E,Goncu B,özdemir b,aysan e,Gurol A "The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery." , ss.275 - 279, 2021. 10.4274/imj.galenos.2021.67984
ISNAD	Idiz, Ufuk Oguz vd. "The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery". (2021), 275-279. https://doi.org/10.4274/imj.galenos.2021.67984

APA	Idiz U, Yucesan E, Goncu B, özdemir b, aysan e, Gurol A (2021). The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery. İstanbul Medical Journal, 22(4), 275 - 279. 10.4274/imj.galenos.2021.67984
Chicago	Idiz Ufuk Oguz,Yucesan Emrah,Goncu Beyza,özdemir burcu,aysan erhan,Gurol Ali Osman The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery. İstanbul Medical Journal 22, no.4 (2021): 275 - 279. 10.4274/imj.galenos.2021.67984
MLA	Idiz Ufuk Oguz,Yucesan Emrah,Goncu Beyza,özdemir burcu,aysan erhan,Gurol Ali Osman The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery. İstanbul Medical Journal, vol.22, no.4, 2021, ss.275 - 279. 10.4274/imj.galenos.2021.67984
AMA	Idiz U,Yucesan E,Goncu B,özdemir b,aysan e,Gurol A The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery. İstanbul Medical Journal. 2021; 22(4): 275 - 279. 10.4274/imj.galenos.2021.67984
Vancouver	Idiz U,Yucesan E,Goncu B,özdemir b,aysan e,Gurol A The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery. İstanbul Medical Journal. 2021; 22(4): 275 - 279. 10.4274/imj.galenos.2021.67984
IEEE	Idiz U,Yucesan E,Goncu B,özdemir b,aysan e,Gurol A "The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery." İstanbul Medical Journal, 22, ss.275 - 279, 2021. 10.4274/imj.galenos.2021.67984
ISNAD	Idiz, Ufuk Oguz vd. "The Importance of Cryopreserved Parathyroid Tissue Autotransplantation in the Hypoparathyroidism Treatment after Secondary Hyperparathyroidism Surgery". İstanbul Medical Journal 22/4 (2021), 275-279. https://doi.org/10.4274/imj.galenos.2021.67984