The role of telomerase in the etiology of primary spontaneous pneumothorax

gürler, fatih; Karakukcu, Cigdem; özsoy, ibrahim ethem; tezcan, mehmet akif

doi:10.5606/tgkdc.dergisi.2021.20522

The role of telomerase in the etiology of primary spontaneous pneumothorax

Mehmet Akif Tezcan, (Göğüs Cerrahisi Anabilim Dalı, Sağlık Bilimleri Üniversitesi, Kayseri Sağlık Uygulama ve Araştırma Merkezi, Kayseri, Türkiye)

İbrahim Ethem Özsoy, (Göğüs Cerrahisi Anabilim Dalı, Sağlık Bilimleri Üniversitesi, Kayseri Sağlık Uygulama ve Araştırma Merkezi, Kayseri, Türkiye)

Fatih Gürler, (Göğüs Cerrahisi Anabilim Dalı, Sağlık Bilimleri Üniversitesi, Kayseri Sağlık Uygulama ve Araştırma Merkezi, Kayseri, Türkiye)

Çiğdem KARAKÜKCÜ (Sağlık Bilimleri Üniversitesi, Kayseri Sağlık Uygulama ve Araştırma Merkezi, Tıbbi Biyokimya Anabilim Dalı, Kayseri, Türkiye)

Türk Göğüs Kalp Damar Cerrahisi Dergisi

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Yıl: 2021 Cilt: 29 Sayı: 3 Sayfa Aralığı: 377 - 383 Metin Dili: İngilizce DOI: 10.5606/tgkdc.dergisi.2021.20522 İndeks Tarihi: 28-05-2022

The role of telomerase in the etiology of primary spontaneous pneumothorax

Öz:

Background: This study aims to investigate the role of telomerase activity in the risk of primary spontaneous pneumothorax, which is most frequently encountered in the practice of thoracic surgery. Methods: A total of 61 patients (56 males, 5 females; median age: 29.4 years; range, 17 to 43 years) who underwent treatment for primary spontaneous pneumothorax and 19 age- and sex-matched healthy controls (10 males, 9 females; median age: 29.1 years; range, 23 to 43 years) were included in this prospective study between January 2018 - August 2018. Telomerase activity was evaluated with enzyme-linked immunosorbent assay. The correlation between telomerase activity and clinical and demographic parameters was examined. Results: The mean serum telomerase level was 3.4±0.6 ng/mL in the primary spontaneous pneumothorax group and 1.9±0.5 ng/mL in the control group, indicating significantly higher levels in the patient group (p<0.001). There was no significant association between the telomerase levels and presence of blebs and/or bullae on thoracic computed tomography, extent of pneumothorax, laterality (right, left, or bilateral), and pack years of cigarette smoking. Conclusion: Telomerase levels of patients with primary spontaneous pneumothorax are significantly higher than healthy individuals. Future genetic studies may ultimately clarify a potential relationship between primary spontaneous pneumothorax and short telomere syndrome.

Anahtar Kelime:

Primer spontan pnömotoraks etiyolojisinde telomerazın rolü

Öz:

Amaç: Bu çalışmada göğüs cerrahisi pratiğinde sıklıkla karşılaşılan primer spontan pnömotoraks riskinde telomeraz aktivitesinin rolü araştırıldı. Çalışma planı: Bu prospektif çalışmaya Ocak 2018 - Ağustos 2018 tarihleri arasında primer spontan pnömotoraks nedeniyle tedavi edilen toplam 61 hasta (56 erkek, 5 kadın; medyan yaş: 29.4 yıl; dağılım, 17-43 yıl) ve yaş ve cinsiyet açısından eşleştirilmiş 19 sağlıklı kontrol (10 erkek, 9 kadın; medyan yaş: 29.1 yıl; dağılım, 23-43 yıl) alındı. Telomeraz aktivitesi enzim bağlı immünosorbent testi ile değerlendirildi. Telomeraz aktivitesi ile klinik ve demografik parametreler arasındaki ilişki incelendi. Bulgular: Ortalama serum telomeraz düzeyleri primer spontan pnömotoraks grubunda 3.4±0.6 ng/mL ve kontrol grubunda 1.9±0.5 ng/mL olup, hasta grubunda düzeyler anlamlı ölçüde daha yüksekti (p<0.001). Telomeraz düzeyleri ile toraks bilgisayarlı tomografide bleb ve/veya bül varlığı, pnömotoraks derecesi, taraf (sağ, sol veya iki taraflı) ve sigara paket yılı arasında anlamlı bir ilişki yoktu. Sonuç: Primer spontan pnömotorakslı hastaların telomeraz düzeyleri, sağlıklı bireylere kıyasla, anlamlı ölçüde daha yüksektir. İleride yapılacak genetik çalışmalar, primer spontan pnömotoraks ile kısa telomer sendromu arasındaki olası ilişkiyi daha net olarak ortaya koyabilir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	tezcan m, özsoy i, gürler f, Karakukcu C (2021). The role of telomerase in the etiology of primary spontaneous pneumothorax. , 377 - 383. 10.5606/tgkdc.dergisi.2021.20522
Chicago	tezcan mehmet akif,özsoy ibrahim ethem,gürler fatih,Karakukcu Cigdem The role of telomerase in the etiology of primary spontaneous pneumothorax. (2021): 377 - 383. 10.5606/tgkdc.dergisi.2021.20522
MLA	tezcan mehmet akif,özsoy ibrahim ethem,gürler fatih,Karakukcu Cigdem The role of telomerase in the etiology of primary spontaneous pneumothorax. , 2021, ss.377 - 383. 10.5606/tgkdc.dergisi.2021.20522
AMA	tezcan m,özsoy i,gürler f,Karakukcu C The role of telomerase in the etiology of primary spontaneous pneumothorax. . 2021; 377 - 383. 10.5606/tgkdc.dergisi.2021.20522
Vancouver	tezcan m,özsoy i,gürler f,Karakukcu C The role of telomerase in the etiology of primary spontaneous pneumothorax. . 2021; 377 - 383. 10.5606/tgkdc.dergisi.2021.20522
IEEE	tezcan m,özsoy i,gürler f,Karakukcu C "The role of telomerase in the etiology of primary spontaneous pneumothorax." , ss.377 - 383, 2021. 10.5606/tgkdc.dergisi.2021.20522
ISNAD	tezcan, mehmet akif vd. "The role of telomerase in the etiology of primary spontaneous pneumothorax". (2021), 377-383. https://doi.org/10.5606/tgkdc.dergisi.2021.20522

APA	tezcan m, özsoy i, gürler f, Karakukcu C (2021). The role of telomerase in the etiology of primary spontaneous pneumothorax. Türk Göğüs Kalp Damar Cerrahisi Dergisi, 29(3), 377 - 383. 10.5606/tgkdc.dergisi.2021.20522
Chicago	tezcan mehmet akif,özsoy ibrahim ethem,gürler fatih,Karakukcu Cigdem The role of telomerase in the etiology of primary spontaneous pneumothorax. Türk Göğüs Kalp Damar Cerrahisi Dergisi 29, no.3 (2021): 377 - 383. 10.5606/tgkdc.dergisi.2021.20522
MLA	tezcan mehmet akif,özsoy ibrahim ethem,gürler fatih,Karakukcu Cigdem The role of telomerase in the etiology of primary spontaneous pneumothorax. Türk Göğüs Kalp Damar Cerrahisi Dergisi, vol.29, no.3, 2021, ss.377 - 383. 10.5606/tgkdc.dergisi.2021.20522
AMA	tezcan m,özsoy i,gürler f,Karakukcu C The role of telomerase in the etiology of primary spontaneous pneumothorax. Türk Göğüs Kalp Damar Cerrahisi Dergisi. 2021; 29(3): 377 - 383. 10.5606/tgkdc.dergisi.2021.20522
Vancouver	tezcan m,özsoy i,gürler f,Karakukcu C The role of telomerase in the etiology of primary spontaneous pneumothorax. Türk Göğüs Kalp Damar Cerrahisi Dergisi. 2021; 29(3): 377 - 383. 10.5606/tgkdc.dergisi.2021.20522
IEEE	tezcan m,özsoy i,gürler f,Karakukcu C "The role of telomerase in the etiology of primary spontaneous pneumothorax." Türk Göğüs Kalp Damar Cerrahisi Dergisi, 29, ss.377 - 383, 2021. 10.5606/tgkdc.dergisi.2021.20522
ISNAD	tezcan, mehmet akif vd. "The role of telomerase in the etiology of primary spontaneous pneumothorax". Türk Göğüs Kalp Damar Cerrahisi Dergisi 29/3 (2021), 377-383. https://doi.org/10.5606/tgkdc.dergisi.2021.20522