Serum zonulin levels are correlated with 
symptom severity independent from body 
mass index and gender in children with 
attention deficit hyperactivity disorder

Kara, Halil; Tuncer, Sibel cigdem; Açıkel, Burak; Cetinkaya, Miray

doi:10.5505/kpd.2022.74317

Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder

Miray ÇETİNKAYA, (Sağlık Bilimleri Üniversitesi, Çocuk ve Ergen Psikiyatrisi Anabilim Dalı, Dr. Sami Ulus Annelik ve Çocuk Eğitimi ve Araştırma Hastanesi, Ankara, Türkiye)

Halil KARA, (Aksaray Üniversitesi, Eğitim ve Araştırma Hastanesi, Çocuk ve Ergen Psikiyatrisi Anabilim Dalı, Aksaray, Türkiye)

Sadettin Burak AÇIKEL, (Çocuk ve Ergen Psikiyatrisi Anabilim Dalı, Konya Şehir Hastanesi, Konya, Türkiye)

Sibel Çiğdem TUNCER (Aksaray Üniversitesi, Klinik Biyokimya, Eğitim ve Araştırma Hastanesi Anabilim Dalı, Aksaray, Türkiye)

Klinik Psikiyatri Dergisi

9 0

Yıl: 2022 Cilt: 25 Sayı: 2 Sayfa Aralığı: 140 - 147 Metin Dili: İngilizce DOI: 10.5505/kpd.2022.74317 İndeks Tarihi: 05-06-2022

Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder

Öz:

Objective: It has been recently emphasized that neurodevelopmental disorders such as schizophrenia, autism spectrum disorder and attention deficit hyperactivity disorder (ADHD) may be related to the gut-brain axis. Zonulin is a protein that changes the integrity of tight junctions between gastrointestinal mucosa cells. We aimed to investigate serum zonulin levels and its relationship with symptom severity in children with ADHD. Method: 21 ADHD patients and 19 controls were included. Zonulin levels were obtained from blood specimens. Clinical severity of the ADHD symptoms was evaluated by Conner’s Parents Rating Scale-Revised/Long Form (CPRS-R/L) and Conner’s Teacher Rating ScaleRevised/Long Form (CTRS-R/L) in ADHD group. Results: There was no significant difference between the groups in terms of age, gender and body mass index. Mean serum zonulin level of the ADHD group was 13.45±9.08 and 21.32± 19.96 in the control group. There was no significant difference between groups (t=1.99, p=0.51). Significant correlation was found (R=0.82, p<0.01) between serum zonulin levels and CTRS-R/L scores in the ADHD group. This correlation persisted when BMI and sex variables were controlled (R=0.85, p<0.01). Discussion: We have found significant correlation between ADHD symptom severity and serum zonulin levels, whereas there was no significant difference between children with ADHD and controls.

Anahtar Kelime:

Dikkat eksikliği hiperaktivite bozukluğu olan çocuklarda serum zonulinseviyelerinin belirti şiddeti, vücut kitle indeksi ve cinsiyet ile ilişkisi

Öz:

Amaç: Şizofreni, otizm spektrum bozukluğu ve dikkat eksikliği hiperaktivite bozukluğu (DEHB) gibi nörogelişimsel bozuklukların bağırsak-beyin ekseniyle ilişkili olabileceği son zamanlarda vurgulanmıştır. Zonulin, gastrointestinal mukoza hücreleri arasındaki sıkı bağlantıların bütünlüğünü değiştiren bir proteindir. DEHB'li çocuklarda serum zonulin düzeylerini ve semptom şiddeti ile ilişkisini araştırmayı amaçladık. Yöntem: 21 DEHB hastası ve 19 kontrol dahil edildi. Zonulin seviyeleri kan örneklerinden elde edildi. DEHB belirtilerinin klinik şiddeti, Conners’ Ebeveyn Derecelendirme Ölçeği-Gözden Geçirilmiş/Uzun Form (CPRS-R/L) ve Conners’ Öğretmen Derecelendirme Ölçeği-Gözden Geçirilmiş/Uzun Form (CTRS-R/L) ile değerlendirildi. Bulgular: Gruplar arasında yaş, cinsiyet ve vücut kitle indeksi (VKİ) açısından anlamlı fark yoktu. DEHB grubunun ortalama serum zonulin düzeyi 13.45 ± 9.08 ve kontrol grubunda 21.32 ± 19.96 idi. Gruplar arasında anlamlı fark yoktu (t = 1.99, p = 0.51). DEHB grubunda serum zonulin düzeyleri ile CTRS-R / L skorları arasında anlamlı korelasyon (R = 0.82, p <0.01) bulundu. Bu korelasyon, VKİ ve cinsiyet değişkenleri kontrol edildiğinde de devam etti (R = 0.85, p <0.01). Sonuç: DEHB semptom şiddeti ile serum zonulin düzeyleri arasında anlamlı bir ilişki bulunmakla birlikte, DEHB olan çocuklar ve kontroller arasında anlamlı bir fark bulunamamıştır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Cetinkaya M, Kara H, Açıkel B, Tuncer S (2022). Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder. , 140 - 147. 10.5505/kpd.2022.74317
Chicago	Cetinkaya Miray,Kara Halil,Açıkel Burak,Tuncer Sibel cigdem Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder. (2022): 140 - 147. 10.5505/kpd.2022.74317
MLA	Cetinkaya Miray,Kara Halil,Açıkel Burak,Tuncer Sibel cigdem Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder. , 2022, ss.140 - 147. 10.5505/kpd.2022.74317
AMA	Cetinkaya M,Kara H,Açıkel B,Tuncer S Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder. . 2022; 140 - 147. 10.5505/kpd.2022.74317
Vancouver	Cetinkaya M,Kara H,Açıkel B,Tuncer S Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder. . 2022; 140 - 147. 10.5505/kpd.2022.74317
IEEE	Cetinkaya M,Kara H,Açıkel B,Tuncer S "Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder." , ss.140 - 147, 2022. 10.5505/kpd.2022.74317
ISNAD	Cetinkaya, Miray vd. "Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder". (2022), 140-147. https://doi.org/10.5505/kpd.2022.74317

APA	Cetinkaya M, Kara H, Açıkel B, Tuncer S (2022). Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder. Klinik Psikiyatri Dergisi, 25(2), 140 - 147. 10.5505/kpd.2022.74317
Chicago	Cetinkaya Miray,Kara Halil,Açıkel Burak,Tuncer Sibel cigdem Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder. Klinik Psikiyatri Dergisi 25, no.2 (2022): 140 - 147. 10.5505/kpd.2022.74317
MLA	Cetinkaya Miray,Kara Halil,Açıkel Burak,Tuncer Sibel cigdem Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder. Klinik Psikiyatri Dergisi, vol.25, no.2, 2022, ss.140 - 147. 10.5505/kpd.2022.74317
AMA	Cetinkaya M,Kara H,Açıkel B,Tuncer S Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder. Klinik Psikiyatri Dergisi. 2022; 25(2): 140 - 147. 10.5505/kpd.2022.74317
Vancouver	Cetinkaya M,Kara H,Açıkel B,Tuncer S Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder. Klinik Psikiyatri Dergisi. 2022; 25(2): 140 - 147. 10.5505/kpd.2022.74317
IEEE	Cetinkaya M,Kara H,Açıkel B,Tuncer S "Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder." Klinik Psikiyatri Dergisi, 25, ss.140 - 147, 2022. 10.5505/kpd.2022.74317
ISNAD	Cetinkaya, Miray vd. "Serum zonulin levels are correlated with symptom severity independent from body mass index and gender in children with attention deficit hyperactivity disorder". Klinik Psikiyatri Dergisi 25/2 (2022), 140-147. https://doi.org/10.5505/kpd.2022.74317