Myoclonic seizures induced by antipsychotic drugs: A case series and literature review
Yıl: 2022 Cilt: 25 Sayı: 2 Sayfa Aralığı: 219 - 222 Metin Dili: İngilizce DOI: 10.5505/kpd.2022.48254 İndeks Tarihi: 05-06-2022
Myoclonic seizures induced by antipsychotic drugs: A case series and literature review
Öz: Introduction: The true frequency of myoclonic seizures
caused by antipsychotics is unknown. Myoclonus associated with clozapine and other antipsychotics has been
shown less frequently than tonic-clonic seizures in the
literature and the treatment protocol is controversial. In
this study, we have compiled current literature data by
presenting our clinical experiences in patients who developed myoclonic seizures with antipsychotic use. Case
Series: The patients were followed up in the inpatient
service of Gazi University Hospital, Department of
Psychiatry between 2014-2019. Demographic data, clinical variables, imaging methods and response to treatment of 10 patients with myoclonic seizures were analyzed. After clinical evaluation, psychiatric diagnoses
were clarified according to DSM-5. Psychotropic drugs
and doses, EEG, MRI examinations and follow-up data
were recorded in these patients with myoclonic seizures.
While 6 of the patients (60%) were receiving clozapine
treatment, other patients using olanzapine, amisulpride
and quetiapine were seen as 2 (20%), 1 (10%) and 1
(10%), respectively. The mean chlorpromazine doseequivalent of the antipsychotics used by all 10 patients
was 876.66 mg per day. In addition to antipsychotic
change, valproic acid was used (most frequently) for the
control of myoclonic seizures in 8 of the patients (80%),
due to insufficient response. Conclusion: Myoclonic
seizures may be misdiagnosed as sudden falls resulting
from generalized tonic-clonic seizures, dyskinesia, and
clozapine induced hypotension. In patients with
myoclonic seizures, use of antipsychotic drugs should be
kept in mind, especially in additional medical conditions
such as renal failure, as well as direct central nervous system pathologies
Anahtar Kelime: Antipsikotik ilaçların neden olduğu miyoklonik nöbetler: Bir olgu dizisi veliteratür incelemesi
Öz: Giriş: Antipsikotiklerle oluşan miyoklonik nöbetlerin
gerçek sıklığı bilinmemektedir. Klozapin ve diğer antipsikotiklerle ilişkili miyoklonus, literatürde tonik-klonik
nöbetlere göre daha az sıklıkla gösterilmiş ve tedavi protokolü tartışmalıdır. Bu çalışmada antipsikotik kullanımı
ile miyoklonik nöbet gelişen hastalarımızda klinik deneyimlerimizi sunarak güncel literatür verilerini derlemiş
bulunmaktayız. Olgu Sunumları: Hastalar Gazi
Üniversitesi Hastanesi Psikiyatri Anabilim Dalı’ nda 2014-
2019 yıllarında takip edilmiştir. Miyoklonik nöbetleri olan
10 hastanın demografik ve klinik verileri, görüntüleme
yöntemleri ve tedavi yanıtları incelendi. Klinik
değerlendirme sonrası DSM-5'e göre psikiyatrik tanıları
netleştirildi. Miyoklonik nöbet görülen bu hastaların
tedavilerinde yer alan psikotrop ilaçlar, dozları, EEG, MRG
sonuçları ve takip verileri kaydedildi. Hastaların 6'sı (%
60) klozapin tedavisi alırken, olanzapin, amisülpirid ve
ketiapin kullanan diğer hastalar sırasıyla 2(% 20), 1(%
10) ve 1(% 10) olarak görüldü. Kullanılan antipsikotiklerin ortalama klorpromazin doz eşdeğeri günde 876.66
mg olarak hesaplandı. Hastaların 8'inde (% 80) miyoklonik nöbetlerin kontrolü için antipsikotik değişimine ek
olarak, yeterli cevap sağlanamaması nedenli, valproik
asit (en sık olarak) kullanıldı. Sonuç: Miyoklonik
nöbetler; jeneralize tonik-klonik nöbetler, diskinezi ve
klozapine bağlı hipotansiyondan kaynaklanan ani
düşmeler olarak yanlış tanı alabilmektedir. Miyoklonik
nöbetleri olan hastalarda direkt santral sinir sistemi
patolojilerinin yanı sıra -özellikle böbrek yetmezliği gibi
ek tıbbi durumlarda- antipsikotik ilaç kullanımı akılda
tutulmalıdır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Olgu Sunumu Erişim Türü: Erişime Açık
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APA | ALTIPARMAK T, YURTSEVEN Ç, Geniş B, COŞAR B (2022). Myoclonic seizures induced by antipsychotic drugs: A case series and literature review. , 219 - 222. 10.5505/kpd.2022.48254 |
Chicago | ALTIPARMAK TAYLAN,YURTSEVEN Çağatay Haşim,Geniş Bahadır,COŞAR Behçet Myoclonic seizures induced by antipsychotic drugs: A case series and literature review. (2022): 219 - 222. 10.5505/kpd.2022.48254 |
MLA | ALTIPARMAK TAYLAN,YURTSEVEN Çağatay Haşim,Geniş Bahadır,COŞAR Behçet Myoclonic seizures induced by antipsychotic drugs: A case series and literature review. , 2022, ss.219 - 222. 10.5505/kpd.2022.48254 |
AMA | ALTIPARMAK T,YURTSEVEN Ç,Geniş B,COŞAR B Myoclonic seizures induced by antipsychotic drugs: A case series and literature review. . 2022; 219 - 222. 10.5505/kpd.2022.48254 |
Vancouver | ALTIPARMAK T,YURTSEVEN Ç,Geniş B,COŞAR B Myoclonic seizures induced by antipsychotic drugs: A case series and literature review. . 2022; 219 - 222. 10.5505/kpd.2022.48254 |
IEEE | ALTIPARMAK T,YURTSEVEN Ç,Geniş B,COŞAR B "Myoclonic seizures induced by antipsychotic drugs: A case series and literature review." , ss.219 - 222, 2022. 10.5505/kpd.2022.48254 |
ISNAD | ALTIPARMAK, TAYLAN vd. "Myoclonic seizures induced by antipsychotic drugs: A case series and literature review". (2022), 219-222. https://doi.org/10.5505/kpd.2022.48254 |
APA | ALTIPARMAK T, YURTSEVEN Ç, Geniş B, COŞAR B (2022). Myoclonic seizures induced by antipsychotic drugs: A case series and literature review. Klinik Psikiyatri Dergisi, 25(2), 219 - 222. 10.5505/kpd.2022.48254 |
Chicago | ALTIPARMAK TAYLAN,YURTSEVEN Çağatay Haşim,Geniş Bahadır,COŞAR Behçet Myoclonic seizures induced by antipsychotic drugs: A case series and literature review. Klinik Psikiyatri Dergisi 25, no.2 (2022): 219 - 222. 10.5505/kpd.2022.48254 |
MLA | ALTIPARMAK TAYLAN,YURTSEVEN Çağatay Haşim,Geniş Bahadır,COŞAR Behçet Myoclonic seizures induced by antipsychotic drugs: A case series and literature review. Klinik Psikiyatri Dergisi, vol.25, no.2, 2022, ss.219 - 222. 10.5505/kpd.2022.48254 |
AMA | ALTIPARMAK T,YURTSEVEN Ç,Geniş B,COŞAR B Myoclonic seizures induced by antipsychotic drugs: A case series and literature review. Klinik Psikiyatri Dergisi. 2022; 25(2): 219 - 222. 10.5505/kpd.2022.48254 |
Vancouver | ALTIPARMAK T,YURTSEVEN Ç,Geniş B,COŞAR B Myoclonic seizures induced by antipsychotic drugs: A case series and literature review. Klinik Psikiyatri Dergisi. 2022; 25(2): 219 - 222. 10.5505/kpd.2022.48254 |
IEEE | ALTIPARMAK T,YURTSEVEN Ç,Geniş B,COŞAR B "Myoclonic seizures induced by antipsychotic drugs: A case series and literature review." Klinik Psikiyatri Dergisi, 25, ss.219 - 222, 2022. 10.5505/kpd.2022.48254 |
ISNAD | ALTIPARMAK, TAYLAN vd. "Myoclonic seizures induced by antipsychotic drugs: A case series and literature review". Klinik Psikiyatri Dergisi 25/2 (2022), 219-222. https://doi.org/10.5505/kpd.2022.48254 |