The comparison of SUVmax values in 18 F-FDG PET/CT
according to cell type, stage, lymph node involvement and
metastasis in lung cancers

Caliskan, Tayfun; ISIK, EMINE GOKNUR; Canoğlu, Kadir

doi:10.4274/gulhane.galenos.2021.1658

The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers

Tayfun ÇALIŞKAN, (Sağlık Bilimleri Üniversitesi, Sultan 2. Abdülhamit Han Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları Kliniği, İstanbul, Türkiye)

Kadir CANOĞLU, (Sağlık Bilimleri Üniversitesi, Sultan 2. Abdülhamit Han Eğitim ve Araştırma Hastanesi, Göğüs Hastalıkları Kliniği, İstanbul, Türkiye)

Emine Göknur IŞIK (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Nükleer Tıp Anabilim Dalı, İstanbul, Türkiye)

Gülhane Tıp Dergisi

11 0

Yıl: 2021 Cilt: 63 Sayı: 4 Sayfa Aralığı: 292 - 296 Metin Dili: İngilizce DOI: 10.4274/gulhane.galenos.2021.1658 İndeks Tarihi: 08-06-2022

The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers

Öz:

Aims: 18 F-fluoro-2-deoxy-D-glucose positron emission tomography/computerized tomography (PET/CT) provides metabolic information in addition to anatomic extension. This study aimed to compare the primary tumor maximum standardized uptake values (SUVmax ) on PET/CT according to the histopathological type, stage, nodal involvement, and the metastasis of lung cancers. Methods: In this retrospective study, PET/CTs of the patients with lung cancer were examined. Staging of the cancer was performed according to the eighth (8 th ) edition of the tumor, node and metastasis (TNM) classification system. SUVmax values were recorded and compared. Results: Two hundred thirty-three patients with lung cancer (78.5% male, mean age: 67.0±9.6 years, range: 47-91 years) were analyzed. The SUVmax value of squamous cell carcinoma (SCC) (15.2±7.6) was higher than the SUVmax values of adenocarcinoma (AC) and small cell lung carcinoma (SCLC) (10.9±5.6 and 12.2±5.5, respectively, p<0.001). SUVmax values were not different between the stages of AC, SCC and SCLC (p=0.285, p=0.377 and p=0.061, respectively). SUVmax values were similar between nodal involvements (p=0.490, p=0.645 and p=0.114 for AC, SCC, and SCLC, respectively). There was no difference in SUVmax values of lung cancers with and without metastasis (p=0.496, p=0.209, and p=0.544 for AC, SCC, and SCLC, respectively). Conclusions: The SUVmax value of SCC was highest among lung cancers. There was no significant difference between the SUVmax value of the primary tumor on PET/CT and the TNM stages of the tumor.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Bade BC, Dela Cruz CS. Lung Cancer 2020: Epidemiology, Etiology, and Prevention. Clin Chest Med. 2020;41:1-24.
2. Howlader N, Noone AM, Krapcho M, et al. SEER Cancer Statistics Review, 1975-2016, National Cancer Institute. Bethesda, MD. Last Accessed Date: 01.04.2019. Available from: https://seer.cancer.gov/csr/1975_2016/
3. Yıldız ÖÖ, Çelik İA. A different perspective on the correlation between histopathological type and PET-CT SUVmax in non-small cell lung cancer: A retrospective cohort study. J Surg Med. 2019;3:357-360.
4. Verma S, Chan J, Chew C, Schultz C. PET-SUV Max and Upstaging of Lung Cancer. Heart Lung Circ. 2019;28:436- 442.
5. Warburg O. Warburg report on the metabolism of tumors. J Chem Educat. 1930;7:179.
6. Dooms C, van Baardwijk A, Verbeken E, et al. Association between 18F-fluoro-2-deoxy-D-glucose uptake values and tumor vitality: prognostic value of positron emission tomography in early-stage non-small cell lung cancer. J Thorac Oncol. 2009;4:822-828.
7. De Leyn P, Dooms C, Kuzdzal J, et al. Preoperative mediastinal lymph node staging for non-small cell lung cancer: 2014 update of the 2007 ESTS guidelines. Transl Lung Cancer Res. 2014;3:225-233.
8. Shepherd FA, Crowley J, Van Houtte P, et al. The International Association for the Study of Lung Cancer lung cancer staging project: proposals regarding the clinical staging of small cell lung cancer in the forthcoming (seventh) edition of the tumor, node, metastasis classification for lung cancer. J Thorac Oncol. 2007;2:1067-1077.
9. Zasadny KR, Wahl RL. Standardized uptake values of normal tissues at PET with 2-[fluorine-18]-fluoro-2-deoxy- D-glucose: variations with body weight and a method for correction. Radiology. 1993;189:847-850.
10. Zhu SH, Zhang Y, Yu YH, et al. FDG PET-CT in non-small cell lung cancer: relationship between primary tumor FDG uptake and extensional or metastatic potential. Asian Pac J Cancer Prev. 2013;14:2925-2929.
11. Iwano S, Ito S, Tsuchiya K, Kato K, Naganawa S. What causes false-negative PET findings for solid-type lung cancer? Lung Cancer. 2013;79:132-136 . 12. Lu P, Yu L, Li Y, Sun Y. A correlation study between maximum standardized uptake values and pathology and clinical staging in nonsmall cell lung cancer. Nucl Med Commun. 2010;31:646-651.
13. Lim W, Ridge CA, Nicholson AG, Mirsadraee S. The 8th lung cancer TNM classification and clinical staging system: review of the changes and clinical implications. Quant Imaging Med Surg. 2018;8:709-718.
14. El-Sherief AH, Lau CT, Wu CC, Drake RL, Abbott GF, Rice TW. International association for the study of lung cancer (IASLC) lymph node map: radiologic review with CT illustration. Radiographics. 2014;34:1680-1691.
15. Said MA, Musarudin M, Zulkaffli NF. The quantification of PET-CT radiotracers to determine minimal scan time using quadratic formulation. Ann Nucl Med. 2020;34:884-891.
16. Sahiner I, Atasever T, Akdemir UO, Ozturk C, Memis L. Relationship between primary lesion metabolic parameters and clinical stage in lung cancer. Rev Esp Med Nucl Imagen Mol. 2013;32:357-363.
17. Berghmans T, Dusart M, Paesmans M, et al. Primary tumor standardized uptake value (SUVmax) measured on fluorodeoxyglucose positron emission tomography (FDG- PET) is of prognostic value for survival in non-small cell lung cancer (NSCLC): a systematic review and meta- analysis (MA) by the European Lung Cancer Working Party for the IASLC Lung Cancer Staging Project. J Thorac Oncol. 2008;3:6-12.
18. Nambu A, Kato S, Sato Y, et al. Relationship between maximum standardized uptake value (SUVmetax) of lung cancer and lymph node metastasis on FDG-PET. Ann Nucl Med. 2009;23:269-275.
19. Al-Sarraf N, Gately K, Lucey J, et al. Clinical implication and prognostic significance of standardised uptake value of primary non-small cell lung cancer on positron emission tomography: analysis of 176 cases. Eur J Cardiothorac Surg. 2008;34:892-897.
20. Billé A, Pelosi E, Skanjeti A, et al. Preoperative intrathoracic lymph node staging in patients with non-small-cell lung cancer: accuracy of integrated positron emission tomography and computed tomography. Eur J Cardiothorac Surg. 2009;36:440-445.
21. Ambrosini V, Nicolini S, Caroli P, et al. PET/CT imaging in different types of lung cancer: an overview. Eur J Radiol. 2012;81:988-1001.
22. Li M, Wu N, Zheng R, et al. Primary tumor PET/CT [18 F] FDG uptake is an independent predictive factor for regional lymph node metastasis in patients with non-small cell lung cancer. Cancer Imaging. 2013;12:566-572.
23. Li M, Liu N, Hu M, et al. Relationship between primary tumor fluorodeoxyglucose uptake and nodal or distant metastases at presentation in T1 stage non-small cell lung cancer. Lung Cancer. 2009;63:383-386.
24. Cerfolio RJ, Bryant AS, Ohja B, Bartolucci AA. The maximum standardized uptake values on positron emission tomography of a non-small cell lung cancer predict stage, recurrence, and survival. J Thorac Cardiovasc Surg. 2005;130:151-159.
25. Obara P, Pu Y. Prognostic value of metabolic tumor burden in lung cancer. Chin J Cancer Res. 2013;25:615-622.

APA	Caliskan T, Canoğlu K, ISIK E (2021). The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers. , 292 - 296. 10.4274/gulhane.galenos.2021.1658
Chicago	Caliskan Tayfun,Canoğlu Kadir,ISIK EMINE GOKNUR The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers. (2021): 292 - 296. 10.4274/gulhane.galenos.2021.1658
MLA	Caliskan Tayfun,Canoğlu Kadir,ISIK EMINE GOKNUR The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers. , 2021, ss.292 - 296. 10.4274/gulhane.galenos.2021.1658
AMA	Caliskan T,Canoğlu K,ISIK E The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers. . 2021; 292 - 296. 10.4274/gulhane.galenos.2021.1658
Vancouver	Caliskan T,Canoğlu K,ISIK E The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers. . 2021; 292 - 296. 10.4274/gulhane.galenos.2021.1658
IEEE	Caliskan T,Canoğlu K,ISIK E "The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers." , ss.292 - 296, 2021. 10.4274/gulhane.galenos.2021.1658
ISNAD	Caliskan, Tayfun vd. "The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers". (2021), 292-296. https://doi.org/10.4274/gulhane.galenos.2021.1658

APA	Caliskan T, Canoğlu K, ISIK E (2021). The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers. Gülhane Tıp Dergisi, 63(4), 292 - 296. 10.4274/gulhane.galenos.2021.1658
Chicago	Caliskan Tayfun,Canoğlu Kadir,ISIK EMINE GOKNUR The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers. Gülhane Tıp Dergisi 63, no.4 (2021): 292 - 296. 10.4274/gulhane.galenos.2021.1658
MLA	Caliskan Tayfun,Canoğlu Kadir,ISIK EMINE GOKNUR The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers. Gülhane Tıp Dergisi, vol.63, no.4, 2021, ss.292 - 296. 10.4274/gulhane.galenos.2021.1658
AMA	Caliskan T,Canoğlu K,ISIK E The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers. Gülhane Tıp Dergisi. 2021; 63(4): 292 - 296. 10.4274/gulhane.galenos.2021.1658
Vancouver	Caliskan T,Canoğlu K,ISIK E The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers. Gülhane Tıp Dergisi. 2021; 63(4): 292 - 296. 10.4274/gulhane.galenos.2021.1658
IEEE	Caliskan T,Canoğlu K,ISIK E "The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers." Gülhane Tıp Dergisi, 63, ss.292 - 296, 2021. 10.4274/gulhane.galenos.2021.1658
ISNAD	Caliskan, Tayfun vd. "The comparison of SUVmax values in 18 F-FDG PET/CT according to cell type, stage, lymph node involvement and metastasis in lung cancers". Gülhane Tıp Dergisi 63/4 (2021), 292-296. https://doi.org/10.4274/gulhane.galenos.2021.1658