Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women
Yıl: 2022 Cilt: 50 Sayı: 1 Sayfa Aralığı: 34 - 45 Metin Dili: İngilizce DOI: 10.5543/tkda.2022.21003 İndeks Tarihi: 17-06-2022
Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women
Öz: Objective: Intelectin-1 is an anti-inflammatory adipokine encoded by the Intelectin 1 (ITLN1) gene. Genetic variations in the ITLN1 gene affect the risk of coronary artery disease (CAD) and related CAD risk factors. In this study, we aimed to investigate whether the ITLN1 gene Val109Asp polymorphism has an effect on the severity of CAD and serum lipid levels in both men and women.
Methods: A total of 493 subjects who underwent coronary angiography (43.5% women, mean age 63.1±9.5 years) were grouped as individuals with critical CAD (≥70% stenosis, n=202), non-critical CAD (31%-69% stenosis, n=90), and non-CAD (control group) (1%-30% stenosis, n=201). Genotyping was performed using LightSNiP assay in Real-Time PCR.
Results: The frequency of the Val allele was significantly different among all the patients with critical CAD (n=41) and non-CAD control (n=51) groups in women (p=0.033) but not in men (n=77 and n=38). Women with the Val allele had a 1.69-fold increased risk for critical CAD (p=0.033). In addition, the presence of Val allele was associated with higher coronary stenosis after adjustment for several confounders only in women with critical CAD (p=0.025). Furthermore, carriers of the Val allele exhibited an increased low-density lipoprotein cholesterol (LDL-C) in men with critical CAD than in those with non-CAD (p<0.05).
Conclusion: These results suggest that the Val allele of the ITLN1 Val109Asp polymorphism is associated with critical CAD and high LDL-C levels in our study population. Further studies are required to elucidate the effect of Val109Asp polymorphism on CAD pathogenesis.
Anahtar Kelime: İntelektin 1 genindeki Val109Asp polimorfizminin kadınlarda koroner arter hastalığı şiddeti ile ilişkisi
Öz: Amaç: Intelektin-1, anti-enflamatuvar bir adipokindir ve Intelektin 1 (ITLN1) geni tarafından kodlanır. ITLN1 genindeki genetik değişimlerin, koroner arter hastalığı (KAH) ve KAH gelişimde rol oynayan risk faktörleri üzerine etkilerinin olduğu öngörülmektedir. Bu çalışmada, ITLN1 Val109Asp polimorfizminin hem erkeklerde hem de kadınlarda KAH’ın şiddeti ve serum lipit düzeyleri üzerine etkilerinin olup olmadığının araştırılması amaçlanmaktadır.
Yöntemler: Koroner anjiyografi (%43.5 kadın, ortalama yaş; 63.1±9.5 yaş) uygulanan 493 birey, belirlenen darlık düzeylerine göre kritik KAH olan (≥%70 darlık, n=202), kritik KAH olmayan (%31-69 darlık, n=90) ve KAH olmayan (kontrol grubu olarak) (%1-30 darlık, n=201) olarak gruplandırıldı. Anjiyografik ciddiyet ve aterosklerotik KAH yaygınlığı Gensini ve SYNTAX skorları kullanılarak değerlendirildi. Genotiplerinin belirlenmesi, Real-Time PCR LightCycler 480 cihazında LightSNiP assay kullanılarak yapıldı.
Bulgular: Seçilen Val109Asp polimorfizmi Val allel sıklığı, kritik KAH olan (n=34) ve KAH olmayan (n=46) kontrol gruplarında kadınlarda anlamlı derecede farklı bulunurken (p=0.033), erkek grupları (n=77 ve n=38) arasında anlamlı bir fark görülmedi. Val alleli taşıyıcısı olan kadınların, kritik KAH için 1.69 kat artmış riske sahip olduğu bulundu (p=0.033). Ek olarak, kritik KAH olan kadınlarda yaş, sigara tüketimi ve lipit düşürücü ilaç kullanımı için ayarlama yapıldığında, Val allel taşıyıcılığı daha yüksek darlık derecesi ile ilişkili bulundu (p=0.025). Ayrıca, bu polimorfizmin Val allelini taşıyıcısı olan kritik KAH sahip erkeklerde LDL-kolesterol (LDL-K) düzeyinde artış görüldü (p<0.05).
Sonuç: Bu sonuçlar, ITLN1 Val109Asp polimorfizmin Val allelinin, kritik KAH ve LDL-K seviyeleri ile ilişkisini göstermektedir. ITLN1 Val109Asp polimorfizminin KAH patogenezi üzerindeki etkisinin aydınlatılması için daha ileri çalışmalara ihtiyaç vardır.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Guclu-Geyik F, Erkan A, Ozuynuk-Ertugrul A, Ekici B, coban n (2022). Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women. , 34 - 45. 10.5543/tkda.2022.21003 |
| Chicago | Guclu-Geyik Filiz,Erkan Aycan Fahri,Ozuynuk-Ertugrul Aybike Sena,Ekici Berkay,coban neslihan Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women. (2022): 34 - 45. 10.5543/tkda.2022.21003 |
| MLA | Guclu-Geyik Filiz,Erkan Aycan Fahri,Ozuynuk-Ertugrul Aybike Sena,Ekici Berkay,coban neslihan Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women. , 2022, ss.34 - 45. 10.5543/tkda.2022.21003 |
| AMA | Guclu-Geyik F,Erkan A,Ozuynuk-Ertugrul A,Ekici B,coban n Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women. . 2022; 34 - 45. 10.5543/tkda.2022.21003 |
| Vancouver | Guclu-Geyik F,Erkan A,Ozuynuk-Ertugrul A,Ekici B,coban n Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women. . 2022; 34 - 45. 10.5543/tkda.2022.21003 |
| IEEE | Guclu-Geyik F,Erkan A,Ozuynuk-Ertugrul A,Ekici B,coban n "Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women." , ss.34 - 45, 2022. 10.5543/tkda.2022.21003 |
| ISNAD | Guclu-Geyik, Filiz vd. "Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women". (2022), 34-45. https://doi.org/10.5543/tkda.2022.21003 |
| APA | Guclu-Geyik F, Erkan A, Ozuynuk-Ertugrul A, Ekici B, coban n (2022). Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women. Türk Kardiyoloji Derneği Arşivi, 50(1), 34 - 45. 10.5543/tkda.2022.21003 |
| Chicago | Guclu-Geyik Filiz,Erkan Aycan Fahri,Ozuynuk-Ertugrul Aybike Sena,Ekici Berkay,coban neslihan Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women. Türk Kardiyoloji Derneği Arşivi 50, no.1 (2022): 34 - 45. 10.5543/tkda.2022.21003 |
| MLA | Guclu-Geyik Filiz,Erkan Aycan Fahri,Ozuynuk-Ertugrul Aybike Sena,Ekici Berkay,coban neslihan Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women. Türk Kardiyoloji Derneği Arşivi, vol.50, no.1, 2022, ss.34 - 45. 10.5543/tkda.2022.21003 |
| AMA | Guclu-Geyik F,Erkan A,Ozuynuk-Ertugrul A,Ekici B,coban n Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women. Türk Kardiyoloji Derneği Arşivi. 2022; 50(1): 34 - 45. 10.5543/tkda.2022.21003 |
| Vancouver | Guclu-Geyik F,Erkan A,Ozuynuk-Ertugrul A,Ekici B,coban n Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women. Türk Kardiyoloji Derneği Arşivi. 2022; 50(1): 34 - 45. 10.5543/tkda.2022.21003 |
| IEEE | Guclu-Geyik F,Erkan A,Ozuynuk-Ertugrul A,Ekici B,coban n "Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women." Türk Kardiyoloji Derneği Arşivi, 50, ss.34 - 45, 2022. 10.5543/tkda.2022.21003 |
| ISNAD | Guclu-Geyik, Filiz vd. "Val109Asp polymorphism in Intelectin 1 gene is associated with coronary artery disease severity in women". Türk Kardiyoloji Derneği Arşivi 50/1 (2022), 34-45. https://doi.org/10.5543/tkda.2022.21003 |
