Assessment of Features of MIS-C and Non-MIS-C 
Patients: Meta-Analysis

Çöl, Meltem; Aydın, Saliha; Baysan, Caner; Özdemir, Caner; BEKAR, TÜRKER; Büyükdemirci, Erkan; gürbüz, sibel

doi:10.5578/flora.20229912

Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis

Caner BAYSAN, (Ankara Üniversitesi, Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, Ankara, Türkiye)

Meltem ÇÖL, (Ankara Üniversitesi, Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, Ankara, Türkiye)

Saliha AYDIN, (Ankara Üniversitesi, Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, Ankara, Türkiye)

Sibel GÜRBÜZ, (Ankara Üniversitesi, Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, Ankara, Türkiye)

Caner ÖZDEMİR, (Ankara Üniversitesi, Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, Ankara, Türkiye)

Türker BEKAR, (Ankara Üniversitesi, Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, Ankara, Türkiye)

Erkan BÜYÜKDEMİRCİ (Ankara İl Sağlık Müdürlüğü, Halk Sağlığı Hizmetleri, Ankara, Türkiye)

Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi

4 2

Yıl: 2022 Cilt: 27 Sayı: 1 Sayfa Aralığı: 158 - 176 Metin Dili: İngilizce DOI: 10.5578/flora.20229912 İndeks Tarihi: 19-06-2022

Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis

Öz:

Introduction: Pediatric COVID-19 cases are typically known to be mildly symptomatic and show a good prognosis. However, more severe condition termed Multisystem inflammatory syndrome (MIS-C) is encountered in children. This research aimed to evaluate the differences between MIS-C and non-MIS-C (children who were infected with SARS-CoV-2 but did not develop MIS-C) patients according to demographics, comorbidities, and symptoms conditions, as well as clinical, laboratory, radiological findings, treatment, and prognosis. Materials and Methods: This systematic review and meta-analysis were performed in accordance with PRISMA guidelines using electronic databases of PubMed, Scopus, Science-Direct, and LitCovid including articles on observational studies comparing the MIS-C and non-MIS-C cases published between 01 January 2020-15 January 2021. Results: Seventeen articles meeting the criteria were included. No difference was found in terms of gender and age from the demographic characteristics of the MIS-C and non-MIS-C groups. Black race and clinical findings such as fever, rash, fatigue, loss of appetite, vomiting and diarrhea, and laboratory findings CRP and ferritin were found to be higher in the MISC group compared to the nonMISC group (p<0.05). Cardiac complications, use of some medical treatments (steroids, IVIG, inotropic therapy), and need for intensive care were also higher (p< 0.05). Conversely, the presence of comorbidity, presence of rhinorrhea, hemoglobin, lymphocyte, and platelet values were higher in the non-MIS-C group (p< 0.05). Conclusion: Evaluation of MIS-C and non-MIS-C patients for various characteristics revealed differences that will guide the diagnosis of and approach to MIS-C cases.

Anahtar Kelime:

MIS-C ve MIS-C Olmayan Hastaların Özelliklerinin Değerlendirilmesi:Meta-Analiz

Öz:

Giriş: Pediatrik COVID-19 vakalarının tipik olarak hafif semptomatik olduğu ve iyi bir prognoz gösterdiği bilinmektedir. Ancak çocuklarda multisistem inflamatuvar sendrom (MIS-C) olarak adlandırılan daha şiddetli bir durumla karşılaşılmaktadır. Bu araştırma, MIS-C ve MIS-C olmayan (SARS-CoV-2 ile enfekte olan ancak MIS-C gelişmeyen çocuklar) hastaların demografik, komorbidite ve semptom özellikleri yanı sıra klinik, laboratuvar, radyolojik bulgular, tedavi ve prognoz farklılıklarının değerlendirilmesini amaçlamaktadır. Materyal ve Metod: Bu sistematik derleme ve meta-analiz, Ocak 2020-15 Ocak 2021 arasında PubMed, Scopus, Science-Direct ve LitCovid elektronik veritabanlarındaki MIS-C ve MIS-C olmayan hastaları karşılaştıran gözlemsel çalışmalara ilişkin makaleler kullanılarak PRISMA rehberine göre yapılmıştır Bulgular: Kriterleri karşılayan 17 makale dahil edildi. MIS-C ve non-MIS-C gruplarının demografik özelliklerinden cinsiyet ve yaş bakımından fark saptanmamış olup, MIS-C grubunda siyah ırk olma olasılığı ve klinik bulgulardan ateş, döküntü, yorgunluk, iştah kaybı, kusma ve ishal, laboratuar bulgulardan CRP ve ferritin non-MIS-C grubuna göre daha yüksek bulunmuştur (p< 0,05). MIS-C grubunda kardiyak komplikasyonlar, bazı medikal tedavilerin kullanımı (steroid, IVIG, inotropik tedavi) ve yoğun bakım ihtiyacı daha yüksek bulunmuştur (p< 0,05). Buna karşılık, MIS-C olmayan grupta komorbidite varlığı, rinore varlığı daha fazla, hemoglobin, lenfosit ve trombosit değerleri daha yüksekti (p< 0,05). Sonuç: MIS-C ve MIS-C olmayan hastaların çeşitli özellikler açısından değerlendirilmesi, MIS-C vakalarının teşhisine ve yaklaşıma yön verecek farklılıkları ortaya çıkarmıştır.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Baysan C, Çöl M, Aydın S, gürbüz s, Özdemir C, BEKAR T, Büyükdemirci E (2022). Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis. , 158 - 176. 10.5578/flora.20229912
Chicago	Baysan Caner,Çöl Meltem,Aydın Saliha,gürbüz sibel,Özdemir Caner,BEKAR TÜRKER,Büyükdemirci Erkan Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis. (2022): 158 - 176. 10.5578/flora.20229912
MLA	Baysan Caner,Çöl Meltem,Aydın Saliha,gürbüz sibel,Özdemir Caner,BEKAR TÜRKER,Büyükdemirci Erkan Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis. , 2022, ss.158 - 176. 10.5578/flora.20229912
AMA	Baysan C,Çöl M,Aydın S,gürbüz s,Özdemir C,BEKAR T,Büyükdemirci E Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis. . 2022; 158 - 176. 10.5578/flora.20229912
Vancouver	Baysan C,Çöl M,Aydın S,gürbüz s,Özdemir C,BEKAR T,Büyükdemirci E Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis. . 2022; 158 - 176. 10.5578/flora.20229912
IEEE	Baysan C,Çöl M,Aydın S,gürbüz s,Özdemir C,BEKAR T,Büyükdemirci E "Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis." , ss.158 - 176, 2022. 10.5578/flora.20229912
ISNAD	Baysan, Caner vd. "Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis". (2022), 158-176. https://doi.org/10.5578/flora.20229912

APA	Baysan C, Çöl M, Aydın S, gürbüz s, Özdemir C, BEKAR T, Büyükdemirci E (2022). Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 27(1), 158 - 176. 10.5578/flora.20229912
Chicago	Baysan Caner,Çöl Meltem,Aydın Saliha,gürbüz sibel,Özdemir Caner,BEKAR TÜRKER,Büyükdemirci Erkan Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 27, no.1 (2022): 158 - 176. 10.5578/flora.20229912
MLA	Baysan Caner,Çöl Meltem,Aydın Saliha,gürbüz sibel,Özdemir Caner,BEKAR TÜRKER,Büyükdemirci Erkan Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, vol.27, no.1, 2022, ss.158 - 176. 10.5578/flora.20229912
AMA	Baysan C,Çöl M,Aydın S,gürbüz s,Özdemir C,BEKAR T,Büyükdemirci E Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2022; 27(1): 158 - 176. 10.5578/flora.20229912
Vancouver	Baysan C,Çöl M,Aydın S,gürbüz s,Özdemir C,BEKAR T,Büyükdemirci E Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis. Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi. 2022; 27(1): 158 - 176. 10.5578/flora.20229912
IEEE	Baysan C,Çöl M,Aydın S,gürbüz s,Özdemir C,BEKAR T,Büyükdemirci E "Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis." Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi, 27, ss.158 - 176, 2022. 10.5578/flora.20229912
ISNAD	Baysan, Caner vd. "Assessment of Features of MIS-C and Non-MIS-C Patients: Meta-Analysis". Flora İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Dergisi 27/1 (2022), 158-176. https://doi.org/10.5578/flora.20229912