Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi

KADIOĞLU, Ateş; Sanli, Oner; AKMAN, Tolga

Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi

Tolga AKMAN, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Üroloji Anabilim Dalı, İstanbul, Türkiye)

Öner ŞANLI, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Üroloji Anabilim Dalı, İstanbul, Türkiye)

Ateş KADIOĞLU (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Üroloji Anabilim Dalı, İstanbul, Türkiye)

Türk Üroloji Dergisi/Turkish Journal of Urology

6 0

Yıl: 2005 Cilt: 31 Sayı: 2 Sayfa Aralığı: 186 - 196 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi

Öz:

Radikal prostatektomi sonrası erektil disfonksiyon % 16-82 oranında görülmektedir. RRP sonrası erektil fonksiyonu temel olarak sinir koruyucu cerrahinin uygulanıp uygulanmaması ve ameliyat öncesi erektil fonksiyon etkilemektedir. Apoptozis RRP sonrası gelişen kavernozal yetersizlikte önemli rol oynamaktadır. RRP sonrası gelişen ED'un tedavisinde, genel ED tedavi prensipleri geçerlidir ve farmakolojik profılaktik tedavi ve değişik tedavi alternatifleri ile ameliyat sonrası erektil fonksiyonun tedavisi etkili ve güvenilirdir. Bunun yanında, PDE5 inhibitörlerinin etkileri benzerdir. Kavernozal sinir rekonstrüksiyonu ve sinir koruyucu ajanlar RRP sonrası gelişen ED tedavisinde umut verici yöntemlerdir.

Anahtar Kelime: Ürolojik cerrahi prosedürler, erkek İmpotans Prostatektomi Dietilstilbestrol Ameliyat sonrası komplikasyonlar Prostat neoplazmları

Konular: Üroloji ve Nefroloji Pediatri Cerrahi

Erectile dysfunction and treatment after retropubic radical prostatectomy

Öz:

Introduction: The incidence of erectile dysfunction in men following radical prostatectomy has been estimated to range between 16% and 82%. The most important predictors of erectile function are preoperative erectile function and nerve sparing nature of the procedure. The former is determined by age and vascular risk-factors whereas the latter is decided by the stage of the tumor and the skill of the surgeon. Apoptosis of corporeal smooth muscle cells plays a significant role in the development of cavernosal dysfunction following radical prostatectomy. Symptomatic therapy may be applied according to the current general standards of treatment in men with erectile dysfunction (ED). In addition, pharmacological prophylaxis and treatment of postoperative ED with different treatment alternatives is effective and safe, and PDE5 inhibitors have similar outcome after radical prostatectomy. The concepts of cavernous nerve reconstruction and neuroprotection have been associated to promising results.

Anahtar Kelime: Diethylstilbestrol Postoperative Complications Prostatic Neoplasms Urologic Surgical Procedures, Male Impotence Prostatectomy

Konular: Üroloji ve Nefroloji Pediatri Cerrahi

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1- Siegel T, Moul JW, Spevak M, et al: The development of erectile dysfunction in men treated for prostate cancer. JUrol, 165:430-435, 2001.
2- Montorsi F, Salonia A, Zanoni M, et al: Counselling the patient with prostate cancer about treatment-related erectile dysfunction, Review. Curr Opin Urol, 11: 611-617,2001.
3- Singer PA, Tasch ES, Stocking C, et al: Sex or survival: Trade-offs between quality and quantity of life.J Clin Oncol, 9: 328-334, 1991.
4- Walsh PC, Lepor H, Eggleston JC, et al: Radical prostatectomy with preservation of sexual function: Anatomical and pathological considerations. Prostate, 4: 473-485,1983.
5- Patick JS, Donatucci CF, Lue T: Anatomy of cavernous nerves distal to prostate: Microdissection study in adult male cadavers, Urology, 42: 145-149, 1993.
6- Takenaka A, Murakami G, Matsubara A, et al: Variation in course of cavernous nerve with special reference to details of topographic relationships near prostatic apex:Histologic study using male cadavers. Urology, 65: 136- 142.2005.
7- Pontes JE, Huber R, Wolf R, et al: Sexual function after radical prostatectomy. Prostate, 8: 123-126, 1986.
8- Walsh PC, Marschke P, Ricker D, et al: Patient-reported urinary continence and sexual function after anatomic radical prostatectomy, Urology, 55: 58-61, 2000.
9- Mulhall JP, Slovick R, Hotaling J, et al: Erectile dysfunction after radical prostatectomy: Hemodynamic profiles and their correlation with the recovery of erectile function. J Urol, 167:1371-1375,2002.
10- Breza J, Aboseif SR, Orvis BR, et al: Detailed anatomy of penile neurovascular structures: surgical significance. J Urol, 141:437-443, 1989.
11 - Rogers CG, Trock BP, Walsh PC, et al: Preservation of accessory pudendal arteries during radical retropubic prostatectomy: surgical technique and results. Urology, 64:148-151,2004.
12- Moreland RB: Is there a role of hypoxemia in penile fibrosis: A viewpoint presented to the Society for the Study of Impotence. Int J Impot Res, 10: 113-120, 1998.
13- Yamanaka M, Shirai M, Shiina H, et al: Loss of antiapoptotic genes in aging rat crura. J Urol, 168: 2296-2300,2002.
14- Yao KS, Clayton M, O'Dwyer PJ, et al: Apoptosis in human adenocarcinoma HT29 cells induced by exposure to hypoxia. J Natl Cancer Inst, 158: 656-659, 1995.
15- Chung WS, Park YY, Kwon SW, et al: The impact of aging on penile hemodynamics in normal responders to pharmacological injection a doppler lonographic study. J Urol, 157:2129-2131, 1997.
16- Klein LT, Miller MI, Buttyan R, et al: Apoptosis in the rat penis after penile denervation. J Urol. 158: 626-630. 1997.
17- Fraiman MC, Lepor H, McCullough AR: Changes in Penile Morphometrics in Men with Erectile Dysfunction after Nerve-Sparing Radical Retropubic Prostatectomy. MolUrol, 3: 109-115, 1999.
18- User HM, Hairston JH, Zelner DJ et al: Penile weight and cell subtype specific changes in a post-radical prostatectomy model of erectile dysfunction. J Urol, 169: 1175-1179,2003.
19. Leungwattanakij S, Bivalacqua TJ, Usta MF, et al: Cavernous neurotomy causes hypoxia and fibrosis in rat corpus cavernosum. J Androl, 24: 239-245, 2003.
20. Kendirci M, Hellstrom WJG: Current concepts in the management of erectile dysfunction in men with prostate cancer review. Clin Prostate Cancer, 3: 87-92, 2004.
21. Scardino PT, Kim ED: Rationale for and results of nevre grafting during radical prostatectomy. Urology, 57: 1016-1019,2001.
22. McCullough AR: Prevention and management of erectile dysfunction following radical prostatectomy. Urol Clin North Am, 28: 613-627, 2001.
23. Stanford JL, Feng Z, Hamilton AS: Urinary and sexual function after radical prostatectomy for clinically localized prostate cancer: The Prostate Cancer Outcomes Study. JAMA, 283: 354-360, 2000.
24. Rosen RC, Cappelleri JC, Gendrano N: The International Index of Erectile Function (IIEF): A state-of-the-sci-ence review. Int J Impot Res, 14: 226-244, 2002
25. Meuleman EJH, Mulders: Erectile function after radical prostatectomy: A review. European Urology, 43: 95-102, 2003.
26. Lue TF, Gleason CA, Brock GB, et al: Intraoperative electrostimulation of the cavernous nerve: Technique, results and limitations. J Urol, 154: 1426-1428, 1995.
27. Klotz L, Herschorn S: Early experience with intraoperative cavernous nerve stimulation with penile tumescence monitoring to improve nerve sparing during radical prostatectomy. Urology, 52: 537-542, 1998.
28. Klotz L, Heaton J, Jewett M, et al: randomized phase 3 study of intraoperative cavernous nerve stimulation with penile tumescence monitoring to improve nerve sparing during radical prostatectomy. J Urol, 164: 1573-8, 2000.
29. Walsh PC, Marschke P, Catalona WJ: Efficacy of first-generation Cavermap to verify location and function of cavernous nerves during radical prostatectomy: A multi-institutional evaluation by experienced surgeons. Urology, 57: 491-494,2001.
30. Holzbeierlein J, Peterson M, Smith JA et al: Variability of results of cavernous nerve stimulation during radical prostatectomy. J Urol, 165: 108-110, 2001.
31. Chang SS, Peterson M, Smith JA, et al: Intraoperative nerve stimulation predicts postoperative potency. Urology, 58: 594-597, 2001.
32. Michl U, Dietz R, Huland H, et al: Is intraoperative electrostimulation of erectile nerves possible? J Urol, 162:1610-1613, 1999.
33. Millesi H: Healing of nerves. Clin Plast Surg, 4: 459-473, 1977.
34. Kim ED, Scardino PT, Kadmon D, et al: Interposition sural nerve grafting during radical retropubic prostatecto¬my. Urology, 57: 211-216, 2001.
35. Quinlan DM, Nelson RJ, Walsh PC: Cavernous nerve grafts restore erectile function in denervated rats. J Urol, 145:380-383,1991.
36. Ball RA, Richie JP, Vickers MA: Microsurgical nerve graft repair of the ablated cavernosal nerves in the rat. J Surg Res, 53:280-286, 1992.
37. Kim ED, Seo JT: Minimally invasive technique for sural nerve harvesting: technical description and follow-up. Urology, 57:921-924, 2001.
38. Mackinnon SE and Dellon AL: Nerve injury and regedical Publishers, 17-31, 1988.
39- Kim ED, Nath R, Kadmon D, et al: Bilateral nerve graft during radical retropubic prostatectomy: 1-year follow up. JUrol, 165: 1950-1956, 2001.
40- Kim ED, Nath R, Slawin KM, et al: Bilateral nerve grafting during radical retropubic prostatectomy: Extended follow-up. Urology, 58: 983-987, 2001.
41- Anastasiadis AG, Benson MC, Rosenwasser MP, et al: Cavernous nerve graft reconstruction during radical prostatectomy or radical cystectomy: Safe and technically feasible. Prostate Cancer Prostatic Dis, 6: 56-60, 2003.
42- Chang DW, Wood CG, Kroll SS, et al: Cavernous nerve reconstruction to preserve erectile function following non-nerve-sparing radical retropubic prostatectomy:A prospective study. Plast Reconstr Surg, 111: 1174-1181,2003.
43- May F, Weidner N, Matiasek, et al: Schwann cell seeded guidance tubes restore erectile function after ablation of cavernous nerves in rats. J Urol, 172: 374-377, 2004.
44. Jppe CD, Jhaveri FM, Klein EA, et al: Role of Viagra after radical prostatectomy. Urology, 55: 241-245, 2000.
45- Zagaja GP, Mhoon DA, Aikens JE, et al: Sildenafıl in the treatment of erectile dysfunction after radical prostatectomy. Urology, 56: 631-634, 2000.
46- Raina R, Lakin MM, Agarwal A, et al: Efficacy and factors associated with successful outcome of sildenafıl citrate use for erectile dysfunction after radical prostatec tomy. Urology, 63: 960-966, 2004.
47- Carson CC, Burnett AL, Levine LA: The efficacy of sildenafil citrate (Viagra) in clinical populations: an update. Urology, 60: 12-27, 2002.
48- Hong EK, Lepor H and McCullough AR: Time dependent patient satisfaction with sildenafıl for erectile dysfunction (ED) after nerve-sparing radical retropubic prostatectomy (RRP) Int J of Impot Res 11 (Sup 1): 15-22,1999.
49- Rabbani F, Stapleton AM, Kattan MW, et al: Factors predicting recovery of erections after radical prostatectomy, J Urol, 64: 1929-1934. 2001.
50- Montorsi F, Mağa T, Strambi LF, et al: Sildenafıl taken at bedtime significantly increases nocturnal erections: Results of a placebo-controlled study. Urology, 20:906-911,2000.
51- Padma-Nathan E, McCullough AR, Giuliano F, et al:Postoperative nightly administration of sildenafıl citrate significantly improves the return of normal spontaneous erectile function after bilateral nerve-sparing radical prostatectomy. J Urol, 4: 375, 2003.
52- Raina R, Lakin MM, Agarwal A, et al: Efficacy and factors associated with successful outcome of sildenafıl citrate use for erectile dysfunction after radical prostatectomy. Urology, 63: 960-966, 2004.
53- Montorsi F, Briganti A, Salonia A, et al: Current and Future Strategies for Preventing and managing erectile dysfunction following radical prostatectomy review. European Urology, 45: 123-133,2004.
54- Brock G, Taylor T, Seger M, et al: Vardenafıl Prospect Group Canada. Efficacy and tolerability of vardenafıl in men with erectile dysfunction following radical prostatectomy. Eur Urol, Sup 1: 152, 2002.
55. Montorsi F, McCullough A, Brock GB, et al: Tadalafıl in the treatment of erectile dysfunction following bilateral nerve-sparing radical retropubic prostatectomy: A rando¬mized, double-blind, placebo-controlled trial. J Urol, 172: 1036-1041,2004.
56. Gontero P, Fontana F, Bagnasacco A, et al: Is there an optimal time for intracavernous prostaglandin El rehabi¬litation following nonnerve sparing radical prostatectomy? Results from a hemodynamic prospective study. J Urol, 169: 2166-2169, 2003.
57. Montorsi F, Guazzoni G, Strambi LF, et al: Recovery of spontaneous erectile function after nerve-sparing radical retropubic prostatectomy with and without early intracavernous injections of alprostadil: Results of a prospective, randomized trial. J Urol, 158: 1408-1410, 1997.
58. Brock G, Tu LM, Linet Ol, et al: Return of spontaneous erection during long-term intracavernosal alprostadil (Caverject) treatment. Urology, 57: 536-541, 2001.
59. Jaffe JS, Antell MR, Greenstein M, et al: Use of intrau-rethral alprostadil in patients not responding to sildenafıl citrate. Urology, 63: 951-954, 2004.
60. Nehra A, Blute ML, Barrett DM, et al: Rationale for combination therapy of intraurethral prostaglandin E(l) and sildenafıl in the salvage of erectile dysfunction patients desiring noninvasive therapy. Int J impot res, 14: 38-42,2002.
61. Raina R, Oder M, Afarwal A, et al: Combination therapy muse enhances sexual satisfaction insildenafil citrate failures following radical prostatectomy. J Urol, 4: 354, 2003.
62. Raina R, Agarwal A, Allamaneni SS, et al: Sildenafıl citrate and vacuum constriction device combination enhances sexual satisfaction in erectile dysfunction after radical prostatectomy. Urology, 65: 360-364, 2005.
63. Gontero P, Fontana F, Zitella A, Montorsi F, et al: A prospective evaluation of efficacy and compliance with a multistep treatment approach for erectile dysfunction in patients after non-nerve sparing radical prostatectomy. BJU, 95:359-365, 2005.
64. Cookson MS, Nadig PW: Long-term results with vacuum constriction device. J Urol. 149: 290-294, 1993.
65. Benoit RM, Naslund MJ, Cohen JK, et al: Complications after radical retropubic prostatectomy in the medicare population. Urology, 55: 116-120, 2000.
66. Khoudary KP, DeWolf WC, Bruning CO, et PI: Imue-diate sexual rehabilitation by simultaneous placement of penile prosthesis in patients undergoing radical prostatectomy: initial results in 50 patients. Urology, 50: 395-399, 1997.
67. Shaw K, Orleans N: Synchronous prostheüc implantation through a trans-scrotal incision: An outcome analysis. J Urol, 828A, 2004.
68. Wilson SK, Delk JR, Henry GD, et al: New surgical technique for sphincter urinary control system using upper transverse scrotal incision. J Urol, 169: 261-4, 2003.
69. Lee MC, El-Sakka Al, Graziottin TM, et al. The effect of vascular endothelial growth factor on a rat model of traumatic arteriogenic erectile dysfunction. J Urol, 167: 761-767, 2002.
70. Jung GW, Spencer EM, LueTF: Growth hormone enhances regeneration of nitric oxide synthase-containing penile nerves after cavernous nevre neurotomy in rats. J Urol, 160: 1899-1904, 1998.
71- Sezen SF, Hoke A, Burnett AL, et al: Immunophilin ligand FK506 is neuroprotective for penile innervation. NatMed, 7: 1073-4,2001.
72- Burnett AL, Becker RE: Non-immunosuppressant immunophilin ligand GPI-1046 promotes cavernous nevre reğeneration. J Urol, 169: 303, 2003.
73. Kim JH, Bennett N, Yoshimura N, et al: Neurorecovery and improved erectile function using muscle derived stem cells (MDSC) in a model of post-radical prostatectomy erectile dysfunction. J Urol, 169: 323, 2003.
74. Kim JH, Bennett NE, Sasaki K, et al: Neurotrophic factor gene therapy: Potential cure for post radical prostatectomy erectile dysfunction. J Urol, 169: 303-4, 2003.

APA	AKMAN T, Sanli O, KADIOĞLU A (2005). Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi. , 186 - 196.
Chicago	AKMAN Tolga,Sanli Oner,KADIOĞLU Ateş Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi. (2005): 186 - 196.
MLA	AKMAN Tolga,Sanli Oner,KADIOĞLU Ateş Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi. , 2005, ss.186 - 196.
AMA	AKMAN T,Sanli O,KADIOĞLU A Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi. . 2005; 186 - 196.
Vancouver	AKMAN T,Sanli O,KADIOĞLU A Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi. . 2005; 186 - 196.
IEEE	AKMAN T,Sanli O,KADIOĞLU A "Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi." , ss.186 - 196, 2005.
ISNAD	AKMAN, Tolga vd. "Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi". (2005), 186-196.

APA	AKMAN T, Sanli O, KADIOĞLU A (2005). Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi. Türk Üroloji Dergisi/Turkish Journal of Urology, 31(2), 186 - 196.
Chicago	AKMAN Tolga,Sanli Oner,KADIOĞLU Ateş Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi. Türk Üroloji Dergisi/Turkish Journal of Urology 31, no.2 (2005): 186 - 196.
MLA	AKMAN Tolga,Sanli Oner,KADIOĞLU Ateş Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi. Türk Üroloji Dergisi/Turkish Journal of Urology, vol.31, no.2, 2005, ss.186 - 196.
AMA	AKMAN T,Sanli O,KADIOĞLU A Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi. Türk Üroloji Dergisi/Turkish Journal of Urology. 2005; 31(2): 186 - 196.
Vancouver	AKMAN T,Sanli O,KADIOĞLU A Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi. Türk Üroloji Dergisi/Turkish Journal of Urology. 2005; 31(2): 186 - 196.
IEEE	AKMAN T,Sanli O,KADIOĞLU A "Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi." Türk Üroloji Dergisi/Turkish Journal of Urology, 31, ss.186 - 196, 2005.
ISNAD	AKMAN, Tolga vd. "Retropubik radikal prostatektomi sonrası erektil disfonksiyon ve tedavisi". Türk Üroloji Dergisi/Turkish Journal of Urology 31/2 (2005), 186-196.