Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones

Kübra DEMİR YAZICI, (İstanbul Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)
Özlen GÜZEL AKDEMİR (İstanbul Üniversitesi, Eczacılık Fakültesi, Farmasötik Kimya Anabilim Dalı, İstanbul, Türkiye)
Journal of research in pharmacy (online)
0 0
Yıl: 2022 Cilt: 26 Sayı: 4 Sayfa Aralığı: 931 - 940 Metin Dili: İngilizce DOI: 10.29228/jrp.191 İndeks Tarihi: 25-07-2022

Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones

Öz:
In our pursuit to discover new anticancer agents, we have synthesized a new series of 2-aryl-1,3- thiazolidin-4-one derivatives carrying a mandelic acid part. Compounds 3a-h and 4a-j have been synthesized with the cyclization of mandelic acid-derived Schiff bases, their structures have been elucidated with spectral methods (1H-NMR, 13C-NMR, and LC/MS-APCI) and elemental analyzes (C, H, N). Five compounds 3d, 3e, 4e, 4f, and 4g chosen as prototypes were evaluated against the full panel of 58 human tumor cell lines in the National Cancer Institute’s in vitro primary cytotoxicity assay (Bethesda, Maryland). Among the tested compound, 3e showed good cytotoxic effects against melanoma cell line UACC-62. Compounds 3d, 4e, 4f, and 4g showed moderate cytotoxic effects, especially against leukemia cell line, RPMI-8226, non-small cell lung cancer cell lines NCI-H23 and HOP-92, central nervous system (CNS) cancer cell lines SF-295 and SNB-75, melanoma cell line UACC-62, and ovarian cancer cell line IGROV1. It is considered that the in vitro test results of selected compounds are promising and an additional mandelic acid moiety to core structure 2-aryl-1,3-thiazolidin-4-one and different modifications may result in effective agents in anticancer treatment.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA YAZICI K, AKDEMİR Ö (2022). Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. , 931 - 940. 10.29228/jrp.191
Chicago YAZICI Kübra DEMİR,AKDEMİR Özlen GÜZEL Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. (2022): 931 - 940. 10.29228/jrp.191
MLA YAZICI Kübra DEMİR,AKDEMİR Özlen GÜZEL Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. , 2022, ss.931 - 940. 10.29228/jrp.191
AMA YAZICI K,AKDEMİR Ö Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. . 2022; 931 - 940. 10.29228/jrp.191
Vancouver YAZICI K,AKDEMİR Ö Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. . 2022; 931 - 940. 10.29228/jrp.191
IEEE YAZICI K,AKDEMİR Ö "Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones." , ss.931 - 940, 2022. 10.29228/jrp.191
ISNAD YAZICI, Kübra DEMİR - AKDEMİR, Özlen GÜZEL. "Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones". (2022), 931-940. https://doi.org/10.29228/jrp.191
APA YAZICI K, AKDEMİR Ö (2022). Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. Journal of research in pharmacy (online), 26(4), 931 - 940. 10.29228/jrp.191
Chicago YAZICI Kübra DEMİR,AKDEMİR Özlen GÜZEL Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. Journal of research in pharmacy (online) 26, no.4 (2022): 931 - 940. 10.29228/jrp.191
MLA YAZICI Kübra DEMİR,AKDEMİR Özlen GÜZEL Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. Journal of research in pharmacy (online), vol.26, no.4, 2022, ss.931 - 940. 10.29228/jrp.191
AMA YAZICI K,AKDEMİR Ö Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. Journal of research in pharmacy (online). 2022; 26(4): 931 - 940. 10.29228/jrp.191
Vancouver YAZICI K,AKDEMİR Ö Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones. Journal of research in pharmacy (online). 2022; 26(4): 931 - 940. 10.29228/jrp.191
IEEE YAZICI K,AKDEMİR Ö "Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones." Journal of research in pharmacy (online), 26, ss.931 - 940, 2022. 10.29228/jrp.191
ISNAD YAZICI, Kübra DEMİR - AKDEMİR, Özlen GÜZEL. "Synthesis and potential antitumor activities of mandelic acid linked 2-aryl-1,3-thiazolidin-4-ones". Journal of research in pharmacy (online) 26/4 (2022), 931-940. https://doi.org/10.29228/jrp.191
Sayfa Oluşturulma Tarihi
24-04-2024 0:7

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