Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon

Ramazan ÇÖL, (Selçuk Üniversitesi, Veteriner Fakültesi, Fizyoloji Anabilim Dalı, Konya, Türkiye)
Zafer DURGUN (Selçuk Üniversitesi, Veteriner Fakültesi, Fizyoloji Anabilim Dalı, Konya, Türkiye)
Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences
3 0
Yıl: 2007 Cilt: 23 Sayı: 1 Sayfa Aralığı: 97 - 106 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon

Öz:
Lökositler, sepsiste gelişen Dissemine İntravasküler Koagulasyon (DİK)'un patogenezinde önemli rol oynamaktadırlar. Lökositler konakçı savunmasındaki faydalı rollerine rağmen ayrıca sepsiste doku hasarının başlaması ve ilerlemesine de sebep olmaktadırlar. Tümör Nekrozis Faktör- a (TNF-α) ve İnterlöykin- 1β (IL-1 β) gibi sitokinler monosit, nötrofil ve endotel hücreleri aktifleştirmektedirler. Yangısel sitokinler endotelyumu antitrombotik yüzeyden protrombotik yüzeye dönüştürmeyle koagulasyon mekanizmasını başlatmaktadırlar. Sözkonusu sitokinler doku faktörü oluşumunu stimüle ederek ekstrinsik ve intrinsik koagulasyon sistemini aktive etmektedirler. Bu sitokinler ayrıca nötrofilleri aktifleştirmekte ve nötrofil elestaz ve oksijen serbest radikalleri gibi yangısel mediyatörleri salmaktadırlar. Sepsiste gelişen çeşitli patojenik etkiler nötrofillerden salınan oksijen radikalleri ve enzimlere bağlanmaktadır. Mevcut derleme sepsiste lökositler ve önemli rolleri hakkında bilgi vermektedir.
Anahtar Kelime: akyuvarlar sepsis serbest radikaller yapışma platelet aktive edici faktör sitokin antikoagulant bağışıksal faktörler nitrik oksit tümör nekroz faktör yaygın damar içi pıhtılaşma

Konular: Veterinerlik

Sepsis, Leukocytes, Cytokines and Disseminated Intravascular coagulation

Öz:
Leukocytes play an important role on the pathogenesis of sepsis-induced disseminated intravascular coagulation. Despite the beneficial role of leukocytes in host defence, these cells may also cause the initation and progression of tissue injury in sepsis. Cytokines such as tumor necrosis factor- oc (TNF-α) and interleukin-1 β (IL-1 β) activate monocytes, neutrophils and endothelial cells. Inflammatory cytokines initate coagulation mechanism by converting endothelium from an antithrombotic surface to a prothrombotic surface. These cytokines activate both the extrinsic and intrinsic coagulation system by stimulating tissue factor production. Moreover, they activate neutrophils to release inflammatory mediators such as neutrophil elestase and oxygen free radicals. Various pathogenic effects that occur in sepsis are attributed to the release of oxygen radicals and enzymes from neutrophils. This review present information about leukocytes and their important roles in sepsis.
Anahtar Kelime: platelet activating factor cytokines anticoagulants immunological factors nitric oxide tumour necrosis factor disseminated intravascular coagulation leukocytes sepsis free radicals adhesions

Konular: Veterinerlik
Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
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APA ÇÖL R, DURGUN Z (2007). Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon. , 97 - 106.
Chicago ÇÖL Ramazan,DURGUN Zafer Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon. (2007): 97 - 106.
MLA ÇÖL Ramazan,DURGUN Zafer Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon. , 2007, ss.97 - 106.
AMA ÇÖL R,DURGUN Z Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon. . 2007; 97 - 106.
Vancouver ÇÖL R,DURGUN Z Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon. . 2007; 97 - 106.
IEEE ÇÖL R,DURGUN Z "Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon." , ss.97 - 106, 2007.
ISNAD ÇÖL, Ramazan - DURGUN, Zafer. "Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon". (2007), 97-106.
APA ÇÖL R, DURGUN Z (2007). Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon. Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences, 23(1), 97 - 106.
Chicago ÇÖL Ramazan,DURGUN Zafer Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon. Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences 23, no.1 (2007): 97 - 106.
MLA ÇÖL Ramazan,DURGUN Zafer Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon. Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences, vol.23, no.1, 2007, ss.97 - 106.
AMA ÇÖL R,DURGUN Z Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon. Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences. 2007; 23(1): 97 - 106.
Vancouver ÇÖL R,DURGUN Z Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon. Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences. 2007; 23(1): 97 - 106.
IEEE ÇÖL R,DURGUN Z "Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon." Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences, 23, ss.97 - 106, 2007.
ISNAD ÇÖL, Ramazan - DURGUN, Zafer. "Sepsis, Lökositler, Sitokinler ve Dissemine İntravasküler koagukasyon". Veteriner Bilimleri Dergisi . Eurasian Journal of Veterinary Sciences 23/1 (2007), 97-106.
Sayfa Oluşturulma Tarihi
22-04-2024 12:50

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