Optik koherens tomografi prensipleri ve uygulamadaki yenilikler

ERDURMAN, Cüneyt; DURUKAN, A. Hakan; Mumcuoglu, Tarkan

Optik koherens tomografi prensipleri ve uygulamadaki yenilikler

Tarkan MUMCUOĞLU, (GATA Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Cüneyt ERDURMAN, (GATA Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Ankara, Türkiye)

A. Hakan DURUKAN (GATA Tıp Fakültesi, Göz Hastalıkları Anabilim Dalı, Ankara, Türkiye)

Türk Oftalmoloji Dergisi

25 2

Yıl: 2008 Cilt: 38 Sayı: 2 Sayfa Aralığı: 168 - 175 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Optik koherens tomografi prensipleri ve uygulamadaki yenilikler

Öz:

Son yıllarda, optik koherens tomografi (OKT) özellikle retina hastalıkları ve glokomda önemli bir tanısal görüntüleme teknolojisi olarak öne çıkmaktadır. Bu teknoloji, retinada funduskopi ile zor fark edilen patolojileri, yüksek çözünürlüklü görüntülerle gösterebilmektedir. Bununla birlikte sonuçlar tekrar edilebilirdir ve kantitatif veriler vermektedir. OKT sonuçlarının bu gibi özelliklerinden dolayı, dünyada yaygın kullanılmaktadır. Tüm diğer görüntüleme yöntemlerinde olduğu gibi bazı artefaktların görülmesi mümkündür. Klinik kullanımı için, bu teknolojinin görüntü elde etme ve veri işleme ile ilgili basit fizik prensiplerini bilmek önemli bir konudur. Klinik uygulamada, bu yeni görüntüleme yönteminin bazı kısıtlılıkları olduğu bilinmelidir. Retina görüntülemesindeki duyarlılık ve görüntüleme hızı artışı için önemli ilerlemeler yapılmaktadır. Bu teknolojinin yakın gelecekte, retina hastalıkları ve glokomun tanısı ve tedavisindeki rolü daha da artacak gibi görünmektedir.

Anahtar Kelime:

Konular: Göz Hastalıkları

Principles and novel clinical applications of optical coherence tomography

Öz:

In the recent years, optical coherence tomography (OCT) has become one of the important diagnostic technologies in the ophthalmology, especially in retinal diseases and glaucoma. This technology provides high resolution cross-sectional images for detecting retinal pathologies even though the microscopic retinal abnormalities are easily noticeable. Additionally, the results are reproducible and exceedingly quantitative. Because of the properties of the OCT results, this technology is in use worldwide. However, as in any other imaging technique, some artifacts are expected to occur. Understanding of the basic physical principles in image acquisition and data processing of this technology is very important issue for clinical use of OCT. Clinicians have to be aware of some limitations of this new imaging device. Significant progress in the field of OCT retinal imaging has been made to improve the sensitivity and imaging speed. It is quite likely that the role of this technology as a method for diagnosis and management of retinal diseases and glaucoma will be further defined in the near future.

Anahtar Kelime:

Konular: Göz Hastalıkları

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

1. Fujimoto JG, Pitris C, Boppart S A, Brezinski ME. Opti cal coherence tomography: an emerging technology for biomedical imaging and optical biopsy. Neoplasia, 2000; 2:9-25.
2. Brezinski ME, Tearnry GJ, Bouma BE, Izatt JA, Hee MR, Swanson EA, Southern JF, Fujimoto JG. Optical co herence tomography for optical biopsy. Properties and de monstration of vascular pathology. Circulation, 1996; 93: 1206-1213.
3. Huang D, Swanson EA, Lin CP, Schuman JS, Stinson WG, Chang W, Hee MR, Flotte T, Gregory K, Puliafito CA, et al.: Optical coherence tomography. Science 1991;254:1178-1181.
4. Swanson EA, Izatt JA, Hee HA. In vivo retinal imaging by optical Coherence tomography. Opt. Lett. 1993; 18: 1864-1866.
5. Bartsch DU, Freeman WR. Axial intensity distribution analysis of the human retina with a confocal scanning la ser tomograph. Exp. Eye Res. 1994; 58: 161-173.
6. Hee MR, Izatt JA, Swanson EA, Huang D, Schuman JS, Lin CP, Puliafito CA, Fujimoto JG. Optical coherence to mography of the human retina. Arch Ophthalmol 1995; 113:325-332.
7. Huang Y, Cideciyan AV, Papastergiou GI, Banin E, Semple-Rowland SL, Milam AH, Jacobson SG. Relation of optical coherence tomography to microanatomy in nor mal and rd chickens. Invest Ophthalmol Vis Sci 1998;39:2405-2416.
8. Hoyt WF, Newman NM. The earliest observable defect in glaucoma? Lancet 1972; 1:692-693.
9. Kerrigan-Baumrind LA, Quigley HA, Pease ME, Kerri gan DF, Mitchell RS. Number of ganglion cells in glauco ma eyes compared with threshold visual field tests in the same persons. Invest Ophthalmol Vis Sci 2000;41:741-748.
10. Utine CA, Eren H, Perente İ, Bayraktar Ş, Yılmaz ÖF. Primer açık açılı glokom olgularında görme alanı defekt skorlamasma göre optik koherens tomografi ölçümlerinin değerlendirilmesi. Glokom-Katarakt 2006; 1: 165-170.
11. Schuman JS, Pedut-Kloizman T, Hertzmark E, Hee MR, Wilkins JR, Coker JG, Puliafito CA, Fujimoto JG, Swan son EA. Reproducibility of nerve fiber layer thickness measurements using optical coherence tomography. Oph thalmology 1996;103:1889-1898.
12. Blumenthal EZ, Williams JM, Weinreb RN, Girkin CA, Berry CC, Zangwill LM. Reproducibility of nerve fiber layer thickness measurements by use of optical coherence tomography. Ophthalmology 2000; 107:2278-2282.
13. Carpineto P, Ciancaglini M, Zuppardi E, Falconio G, Do ronzö E, Mastropasqua L. Reliability of nerve fiber layer thickness measurements using optical coherence tomog raphy in normal and glaucomatous eyes. Ophthalmology 2003;l 10:190-195.
14. Paunescu LA, Schuman JS, Price LL, Stark PC, Beaton S, Ishikawa H, Wollstein G, Fujimoto JG. Reproducibility of nerve fiber thickness, macular thickness, and optic ner ve head measurements using stratusoct. Invest Ophthal mol Vis Sci 2004;45:1716-1724.
15. Budenz DL, Chang RT, Huang X, Knighton RW, Tielsch JM. Reproducibility of retinal nerve fiber thickness mea surements using the stratus oct in normal and glaucoma tous eyes. Invest Ophthalmol Vis Sci 2005;46:2440-2443.
16. Bayraktar Ş, Türker G. Erken glokom ve glokom şüphesi olgularında optik koherens tomografi ile elde edilen retina sinir lifi kalınlığı ölçümlerinin tekrarlanabilirliği. T. Oft. Gaz. 2000; 30: 404-408.
17. Leung CK, Yung WH, Ng AC, Woo J, Tsang MK, Tse KK. Evaluation of scanning resolution on retinal nerve fi ber layer measurement using optical coherence tomog raphy in normal and glaucomatous eyes. J Glaucoma 2004; 13:479-485.
18. Schuman JS, Hee MR, Puliafito CA, Wong C, Pedut-Klo izman T, Lin CP, Hertzmark E, Izatt JA, Swanson EA, Fujimoto JG. Quantification of nerve fiber layer thickness in normal and glaucomatous eyes using optical coherence tomography. Arch Ophthalmol 1995; 113:586-596.
19. Sanchez-Galeana CA, Bowd C, Zangwill LM, Sample PA, Weinreb RN. Short-wavelength automated perimetry results are correlated with optical coherence tomography retinal nerve fiber layer thickness measurements in glau comatous eyes. Ophthalmology 2004; 111:1866-1872.
20. Bowd C, Weinreb RN, Williams JM, Zangwill LM. The retinal nerve fiber layer thickness in ocular hypertensive, normal, and glaucomatous eyes with optical coherence to mography. Arch Ophthalmol 2000; 118:22-26.
21. Bowd C, Zangwill LM, Berry CC, Blumenthal EZ, Vasile C, Sanchez-Galeana C, Bosworth CF, Sample PA, Wein reb RN. Detecting early glaucoma by assessment of reti nal nerve fiber layer thickness and visual function. Invest Ophthalmol Vis Sci 2001 ;42:1993-2003.
22. Medeiros FA, Zangwill LM, Bowd C, Weinreb RN. Comparison of the GDx VCC scanning laser polarimeter, HRT II confocal scanning laser ophthalmoscope, and stratus oct optical coherence tomograph for the detection of glaucoma. Arch Ophthalmol 2004; 122:827-837.
23. Mrugacz M, Bakunowicz-Lazarczyk A. Optical coheren ce tomography measurement of the retinal nerve fiber la yer in normal and juvenile glaucomatous eyes. Ophthal mologica 2005;219:80-85.
24. Hess DB, Asrani SG, Bhide MG, Enyedi LB, Stinnett SS, Freedman SF. Macular and retinal nerve fiber layer analy sis of normal and glaucomatous eyes in children using op tical coherence tomography. Am J Ophthalmol 2005;139:509-517.
25. Leung CK, Chan WM, Yung WH, Ng AC, Woo J, Tsang MK, Tse RK. Comparison of macular and peripapillary measurements for the detection of glaucoma: An optical coherence tomography study. Ophthalmology 2005;112:391-400.
26. Wollstein G, Schuman JS, Price LL, Aydin A, Beaton SA, Stark PC, Fujimoto JG, Ishikawa H. Optical coheren ce tomography (OCT) macular and peripapillary retinal nerve fiber layer measurements and automated visual fi elds. Am J Ophthalmol 2004;138:218-225.
27. Varma R, Skaf M, Barron E. Retinal nerve fiber layer thickness in normal human eyes. Ophthalmology 1996;103:2114-2119.
28. Savini G, Zanini M, Carelli V, Sadun AA, Ross-Cisneros FN, Barboni P. Correlation between retinal nerve fibre la yer thickness and optic nerve head size: An optical cohe rence tomography study. Br J Ophthalmol 2005;89:489-492.
29. Jonas AL, Sheen NJ, North RV, Morgan JE. The Hump hrey optical coherence tomography scanner: quantitative analysis and reproducibilty study of the normal human re tinal nevre fibre layer. Br.J. Ophthalmol. 2001; 85: 673-677.
30. Skaf M, Bernandes AB, Cardillo JA, Costa RA, Melo LA, Castro JC, Varma R. Retinal nerve fiber layer thick ness profile in normal eyes using third-generation optical coherence tomography. Eye. 2006; 20: 431-439.
31. Wollstein G, Paunescu LA, Ko TH, Fujimoto JG, Kowa levicz A, Hartl I, Beaton S, Ishikawa H, Mattox C, Singh O, Duker J, Drexler W, Schuman JS. Ultrahigh-resolution optical coherence tomography in glaucoma. Ophthalmo logy 2005; 112:229-237.
32. Wojtkowski M, Srinivasan V, Fujimoto JG, Ko T, Schu man JS, Kowalczyk A, Duker JS. Three-dimensional reti nal imaging with high-speed ultrahigh-resolution optical coherence tomography. Ophthalmology 2005; 112:1734-1746.
33. Wollstein G, Ishikawa H, Wang J, Beaton SA, Schuman JS. Comparison of three optical coherence tomography scanning areas for detection of glaucomatous damage. Am J Ophthalmol. 2005; 139: 39-43.
34. Drexler W, Morgner U, Kartner FX, Pitris C, Boppart SA, Li XD, Ippen EP, Fujimoto JG. In vivo ultrahigh-re solution optical coherence tomography. Opt.Lett. 1999; 24: 1221-1223.
35. Drexler W, Morgner U, Ghanta RK, Kartner FX, Schu man JS, Fujimoto JG. Ultrahigh-resolution ophthalmic optical coherence tomography. Nat Med 2001;7:502-507.
36. Drexler W, Sattmann H, Hermann B, Ko TH, Stur M, Un terhuber A, Scholda C, Findl O, Wirtitsch M, Fujimoto JG, Fercher AF. Enhanced visualization of macular pat hology with the use of ultrahigh-resolution optical cohe rence tomography. Arch Ophthalmol 2003; 121:695-706.
37. Fujimoto JG. Optical coherence tomography for ultrahigh resolution in vivo imaging. Nat Biotechnol 2003;21:1361-1367.
38. Wojtkowski M, Leitgeb R, Kowalczyk A, Bajraszewski T, Fercher AF. In vivo human retinal imaging by fourier domain optical coherence tomography. J Biomed Opt 2002;7:457-463.
39. Wojtkowski M, Bajraszewski T, Targowski P, Ko walczyk A. Real-time in vivo imaging by high-speed spectral optical coherence tomography. Opt Lett 2003;28:1745-1747.
40. Ishikawa H, Gabriele ML, Wollstein G, Ferguson RD, Hammer DX, Paunescu LA, Beaton SA, Schuman JS. Re tinal nerve fiber layer assessment using optical coherence tomography with active optic nevre head tracking. Invest Ophthalmol Vis.Sci. 2006; 47: 964-967.

APA	Mumcuoglu T, ERDURMAN C, DURUKAN A (2008). Optik koherens tomografi prensipleri ve uygulamadaki yenilikler. , 168 - 175.
Chicago	Mumcuoglu Tarkan,ERDURMAN Cüneyt,DURUKAN A. Hakan Optik koherens tomografi prensipleri ve uygulamadaki yenilikler. (2008): 168 - 175.
MLA	Mumcuoglu Tarkan,ERDURMAN Cüneyt,DURUKAN A. Hakan Optik koherens tomografi prensipleri ve uygulamadaki yenilikler. , 2008, ss.168 - 175.
AMA	Mumcuoglu T,ERDURMAN C,DURUKAN A Optik koherens tomografi prensipleri ve uygulamadaki yenilikler. . 2008; 168 - 175.
Vancouver	Mumcuoglu T,ERDURMAN C,DURUKAN A Optik koherens tomografi prensipleri ve uygulamadaki yenilikler. . 2008; 168 - 175.
IEEE	Mumcuoglu T,ERDURMAN C,DURUKAN A "Optik koherens tomografi prensipleri ve uygulamadaki yenilikler." , ss.168 - 175, 2008.
ISNAD	Mumcuoglu, Tarkan vd. "Optik koherens tomografi prensipleri ve uygulamadaki yenilikler". (2008), 168-175.

APA	Mumcuoglu T, ERDURMAN C, DURUKAN A (2008). Optik koherens tomografi prensipleri ve uygulamadaki yenilikler. Türk Oftalmoloji Dergisi, 38(2), 168 - 175.
Chicago	Mumcuoglu Tarkan,ERDURMAN Cüneyt,DURUKAN A. Hakan Optik koherens tomografi prensipleri ve uygulamadaki yenilikler. Türk Oftalmoloji Dergisi 38, no.2 (2008): 168 - 175.
MLA	Mumcuoglu Tarkan,ERDURMAN Cüneyt,DURUKAN A. Hakan Optik koherens tomografi prensipleri ve uygulamadaki yenilikler. Türk Oftalmoloji Dergisi, vol.38, no.2, 2008, ss.168 - 175.
AMA	Mumcuoglu T,ERDURMAN C,DURUKAN A Optik koherens tomografi prensipleri ve uygulamadaki yenilikler. Türk Oftalmoloji Dergisi. 2008; 38(2): 168 - 175.
Vancouver	Mumcuoglu T,ERDURMAN C,DURUKAN A Optik koherens tomografi prensipleri ve uygulamadaki yenilikler. Türk Oftalmoloji Dergisi. 2008; 38(2): 168 - 175.
IEEE	Mumcuoglu T,ERDURMAN C,DURUKAN A "Optik koherens tomografi prensipleri ve uygulamadaki yenilikler." Türk Oftalmoloji Dergisi, 38, ss.168 - 175, 2008.
ISNAD	Mumcuoglu, Tarkan vd. "Optik koherens tomografi prensipleri ve uygulamadaki yenilikler". Türk Oftalmoloji Dergisi 38/2 (2008), 168-175.