The effects of oral levothyroxine sodium application on serum copper concentration in rabbits

KARADEMİR, Başaran

The effects of oral levothyroxine sodium application on serum copper concentration in rabbits

Başaran KARADEMİR (Kafkas Üniversitesi, Veteriner Fakültesi, Kars, Türkiye)

Kafkas Üniversitesi Veteriner Fakültesi Dergisi

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Yıl: 2009 Cilt: 15 Sayı: 6 Sayfa Aralığı: 937 - 942 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

The effects of oral levothyroxine sodium application on serum copper concentration in rabbits

Öz:

Bu çalışma oral %0.1’lik CuSO4 ile birlikte Levotiroksin Sodyum (T4) uygulamalarının serum Cu konsatrasyonu üzerindeki etkisinin tespit edilmesi için yapılmıştır. Kırk adet erkek Yeni Zelanda ırkı tavşan (6 aylık, ortalama ağırlıkları 2.29±0.06 kg) dört gruba ayrıldı. Bütün grupların içme sularına %0.1 CuSO4 (*5H2O) çalışmanın başından itibaren eklendi. Üç çalışma grubuna, kontrol grubu hariç 1.67, 3.33 ve 6.67 μg/kg-CA/gün dozunda T4 oral olarak uygulandı. Serum Cu ölçümleri Alev sistemli Atomic Absorbsiyon Spektrofotometre ile yapıldı. Takibenden günlerde serum Cu düzeyleri arttı ve uygulanan T4 miktarı ile serum Cu düzeyi arasında korelasyon tespit edildi (r=0.832, P<0.001). T4, serum Cu düzeyini en küçük r2=56.9% ve P<0.001 düzeyinde etkiledi. Serum Cu düzeyleri üzerinde zamanın etkisi önemli bulundu (P<0.001). Aynı zamanda serum Cu düzeyleri üzerinde zaman ve gruplar arasında etkileşim vardı (P<0.001). Sonuç olarak, T4 serum Cu düzeyinde ikinci gün artışa sebep oldu ve artan bu düzey T4 uygulamalarının devamı ile birlikte sürdü.

Anahtar Kelime: kan kimyası tavşan tiroksin bakır sülfat bakır

Konular: Veterinerlik

Tavşanlarda oral levotiroksin sodyum uygulamasının Serum bakır konsantrasyonu üzerine etkileri

Öz:

This study was carried out to determine the effect of oral Levothyroxine Sodium (T4) applications with oral CuSO4 (0.1%) on serum copper (Cu) concentration. Forty male New Zealand rabbits (6 month-old, weighing 2.29±0.06 kg) were allocated to four groups. All groups received 0.1% CuSO4 (*5H2O) (Copper (II) sulfate pentahydrate M102787) in drinking water with the beginning of the study. T4 was applied orally to three experimental groups at the doses of 1.67, 3.33 and 6.67 μg/kg-BW/day except control group. Serum Cu measurements were performed by Atomic Absorption Spectrometer equipped with Flame system. Serum Cu levels were increased on the following days and correlated with applied dose of T4 (r=0.832, P<0.001). The T4 affected serum Cu level with minimum r2=56.9% and P<0.001. The effect of time was found significant on serum Cu levels (P<0.001). There was also an interaction between time and groups on serum Cu levels (P<0.001). Consequently, T4 caused an increase in serum Cu level at second day and this increase continued on the following days..

Anahtar Kelime: copper blood chemistry rabbits thyroxine copper sulfate

Konular: Veterinerlik

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KARADEMİR B (2009). The effects of oral levothyroxine sodium application on serum copper concentration in rabbits. , 937 - 942.
Chicago	KARADEMİR Başaran The effects of oral levothyroxine sodium application on serum copper concentration in rabbits. (2009): 937 - 942.
MLA	KARADEMİR Başaran The effects of oral levothyroxine sodium application on serum copper concentration in rabbits. , 2009, ss.937 - 942.
AMA	KARADEMİR B The effects of oral levothyroxine sodium application on serum copper concentration in rabbits. . 2009; 937 - 942.
Vancouver	KARADEMİR B The effects of oral levothyroxine sodium application on serum copper concentration in rabbits. . 2009; 937 - 942.
IEEE	KARADEMİR B "The effects of oral levothyroxine sodium application on serum copper concentration in rabbits." , ss.937 - 942, 2009.
ISNAD	KARADEMİR, Başaran. "The effects of oral levothyroxine sodium application on serum copper concentration in rabbits". (2009), 937-942.

APA	KARADEMİR B (2009). The effects of oral levothyroxine sodium application on serum copper concentration in rabbits. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 15(6), 937 - 942.
Chicago	KARADEMİR Başaran The effects of oral levothyroxine sodium application on serum copper concentration in rabbits. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 15, no.6 (2009): 937 - 942.
MLA	KARADEMİR Başaran The effects of oral levothyroxine sodium application on serum copper concentration in rabbits. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.15, no.6, 2009, ss.937 - 942.
AMA	KARADEMİR B The effects of oral levothyroxine sodium application on serum copper concentration in rabbits. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2009; 15(6): 937 - 942.
Vancouver	KARADEMİR B The effects of oral levothyroxine sodium application on serum copper concentration in rabbits. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2009; 15(6): 937 - 942.
IEEE	KARADEMİR B "The effects of oral levothyroxine sodium application on serum copper concentration in rabbits." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 15, ss.937 - 942, 2009.
ISNAD	KARADEMİR, Başaran. "The effects of oral levothyroxine sodium application on serum copper concentration in rabbits". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 15/6 (2009), 937-942.