Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat

Etikan, Ilker; ÇETİN, İlhan; ŞAHİN, Şemsettin; YILDIRIM, Beytullah; Şahin, İdris

Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat

İlhan ÇETİN, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Halk Sağlığı Anabilim Dalı, Tokat, Türkiye)

Beytullah YILDIRIM, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Gastroenteroloji Anabilim Dalı, Tokat, Türkiye)

Şemsettin ŞAHİN, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Tokat, Türkiye)

İdris ŞAHİN, (İnönü Üniversitesi, Tıp Fakültesi, Nefroloji Anabilim Dalı, Malatya, Türkiye)

İlker ETİKAN (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Biyoistatistik Anabilim Dalı, Tokat, Türkiye)

Turkish Journal of Medical Sciences

2 0

Yıl: 2010 Cilt: 40 Sayı: 5 Sayfa Aralığı: 771 - 782 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat

Öz:

Amaç: Çalışmamızda Orta Karadeniz bölgesinde yer alan Tokat ili genelinde yaşayan kişilerde toplam,LDLve HDL kolesterol , Trigliserid miktarları ile dislipidemi prevalansı ve bunları etkileyen faktörler araştırılmıştır. Yöntem ve gereç: Çalışma 58 kırsal ve 12 kentsel yerleşim yerinde gerçekleştirilmiştir. Araştırmanın yapıldığı yerleşim yerleri tabakalı örnekleme yöntemiyle seçilmiştir. Araştırmaya katılan toplam 1.095 kişi ise yerleşim yerlerinden rastgele örneklem yöntemiyle seçilmiştir. Bulgular: Araştırmaya katılan kişilerin ortalama kolesterol miktarı 186 ± 42 mg/dL olup bu kişilerin % 33,7’sinde hiperkolesterolemi (≥200 mg/dL) mevcuttu. Ortalama HDL- kolesterol miktarı 42 ± 11 mg/dL olup katılımcıların % 50,9’u düşük HDL- kolesterol seviyesine (<40 mg/dL) sahipti. Ortalama LDL kolesterol miktarı 119 ± 37 mg/dL olup katılımcıların % 36,2’sı yüksek LDL- kolesterol seviyesine (≥130 mg/dL) sahipti. Ortlama trigliserid miktarı 142 ± 82 mg/dL olup kişilerin % 36,1’i yüksek trigliserid seviyesine (≥150 mg/dL) sahipti. Toplam kolesterol /HDL kolesterol oranı ise 4,7 ± 1,4 olup katılımcıların % 36,3’ü yüksek toplam kolesterol /HDL kolesterol oranına (≥5) sahipti.Sonuç: Türk milletinde daha önceden de yapılmış araştırmaların önemli bir kısmında belirtiltildiği gibi Tokat ili genelinde yaşayan insanlarda normal veya normale yakın toplam kolesterol ve LDL kolesterol seviyesine rağmen, HDL- kolesterol seviyesi düşük bulunmuş olup araştırma yapılan kişilerde dislipidemi sıklığı yüksek bulunmuştur.

Anahtar Kelime:

Konular: Cerrahi

Tokat ilinde yaşayan Türk toplumunda serum lipid, lipoprotein seviyeleri ve dislipidemi prevalansı ile bu parametreleri etkileyen faktörler

Öz:

Abstract: To determine the mean total LDL and HDL cholesterol values and trigliseride levels as well as dyslipidemia and the factors that influence the parameters mentioned above in the population living in the province of Tokat located in the Middle Black Sea (Northeastern) region of Turkey. Materials and methods: The study was performed in 58 rural and 12 urban residential areas. The 58 rural regions were selected using a cluster sampling method. A total of 1095 subjects were selected through a random sampling method. Results: The total serum cholesterol level was 186 ± 42 mg/dL with 33.7% of the participants having hypercholesterolemia (>=200 mg/dL). The HDL-cholesterol level was 42 ± 11 mg/dL with 50.9% of the participants having low HDL-cholesterol levels (<40 mg/dL). The LDL cholesterol level was 119 ± 37 mg/dL with 36.2% of the participants having high LDL-cholesterol levels (>=130 mg/dl). The Triglyceride level was 142 ± 82 mg/dL with 36.1% of the participants having high triglycerides levels (>=150 mg/dL). The TC/HDL ratio was 4.7 ± 1.4 with 36.3% of the participants having high TC/HDL ratio levels (>=5). Conclusion: In agreement with previous studies, we found Turkish people have low HDL-C levels despite normal or near normal levels of TC and LDL-C.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

1. Onat A, Surdum-Avci G, Senocak M, Örnek E, Gözükara Y. Plasma lipids and their relationship in Turkish adults. J Epidemiol Community Health 1992; 46: 470-476.
2. World Health Organization: The World Health Report “Reducing risks, Promoting Healthy Life”, Quantifying Selected Major Risks to Health. Geneva, World Health Organization, 2002:47-92.
3. Mahley RW, Palaoglu KE, Atak Z, Dawson-Pepin J, Langlois AM, Cheung V et al. Turkish Heart Study: lipids, lipoproteins, and apolipoproteins. J Lipid Res 1995; 36: 839-859.
4. Ozkara A, Turgut F, Kanbay M, Selcoki Y, Akcay A. Population-based cardiovascular risk factors in the elderly in Turkey: a cross-sectional survey. Cent Eur J Med 2008; 3: 173-178.
5. Bersot TP, Palaoglu K E, Mahley R W. Managing Dyslipidemia in Turkey: Suggested Guidelines for a Population Characterized by Low Levels of High Density Lipoprotein Cholesterol. Anadolu Kardiyol Derg. 2002; 4: 315-322.
6. The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III): final report. Circulation 2002; 106: 3143-3421.
7. Schaefer EJ. Lipoproteins, nutrition, and heart disease. Am J Clin Nutr 2002; 75: 191-212.
8. Erem C, Hacihasanoglu A, Deger O, Kocak M, Topbas M. Prevalence of dyslipidemia and associated risk factors among Turkish adults: Trabzon lipid study. Endocr 2008; 34: 36–51.
9. Foucan L, Kangambega P, Koumavi Ekouevi D, Rozet J, Bangou-Bredent J. Lipid profile in an adult population in Guadeloupe. Diabetes Metab 2000; 26: 473-480.
10. Onat A: Risk factors and cardiovascular disease in Turkey. Atherosclerosis 2001; 156: 1-10
11. Schaefer EJ, Lamon-Fava S, Ordovas JM, Cohn SD, Schaefer MM, Castelli WP et al. Factors associated with low and elevated plasma high density lipoprotein cholesterol and apolipoprotein A-I levels in the Framingham Offspring Study. J Lipid Res 1994; 35: 871-882.
12. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults(Adult Treatment Panel III), JAMA 2001; 285: 2486-2497.
13. Mahley RW, Pépin GM, Bersot TP, Palaoğlu KE, Özer K. New Findings of the Turkish Heart Study: Guiding Treatment Suggestions for Levels of Plasma Lipids and Low HDL. Arch Turk Soc Cardiol 2002; 30: 93-103.
14. Adam B, Talu C, Bedir A, Alvur M, Sa kan O. The levels of lipids, lipoproteins and apolipoproteins in healthy people in the central region of the Black Sea. Jpn Heart J 1999; 40: 427-434.
15. Mula-abed W S, Chilmeran S K. Prevalence of dyslipidemia in Iraq adult population. Saudi Med J 2007; 28: 1868-1874.
16. Azizi F, Rahmani M, Ghanbarian A, Emami H, Salehi P, Mirmiran P et al. Serum lipid levels in an Iranian adults population: Tehran Lipid and Glucose Study. Eur J Epidemiol 2003; 18: 311-319.
17. Johnson CL, Rifkind BM, Sempos CT, Carroll MD, Bachorik PS, Briefel RR et al. Declining serum total cholesterol levels among US adults. The National Health and Nutrition Examination Surveys. J Am Med Assoc 1993; 269: 3002-3008.
18. Connelly P W, Maclean D R, Horlick L, O’Connor B, Petrasovits A, Little A, Canadian Heart Health Surveys Research Group. Plasma Lipids and lipoproteins and the prevalence of risk for coronary heart disease in Canadian adults. CMAJ 1992; 146: 1977.
19. Onat A. Lipids, lipoproteins and apolipoproteins among turks, and impact on coronary heart disease. Anadolu Kardiyol Derg 2004; 4: 236-245.
20. He J, Gu D, Reynolds K, Wu X, Muntner P, Zhao J et al. InterASIA Collaborative Group. Serum total and lipoprotein cholesterol levels and awareness, treatment, and control of hypercholesterolemia in China. Circulation 2004;110:405-411.
21. Castelli WP, Garrison RJ, Wilson PW, Abbott RD, Kalousdian S, Kannel WB. Incidence of coronary heart disease and lipoprotein cholesterol levels. The Framingham Study. JAMA 1986; 256: 2835-2838
22. Assmann G, Cullen P, Schulte H. The Münster Heart Study (PROCAM). Results of follow-up at 8 years. Eur Heart J 1998;19 (Suppl. A): A2-A11
23. Assmann G, Schulte H. Relation of high-density lipoprotein cholesterol and triglycerides to incidence of atherosclerotic coronary artery disease (the PROCAM experience). Prospective Cardiovascular Münster study. Am J Cardiol 1992; 70:733-737.
24. Onat A, Yıldırım B, Cetinkaya A, Aksu H, Keleş İ, Uslu N et al. Indices of obesity and central obesity in Turkish adults: Distinct rise in obesity in 1990-98 more pronounced among men (in Turkish). Arch Turk Soc Cardiol 1999;27:209-217.
25. Dattilo AM, Kris-Etherton PM. Effects of weight reduction on blood lipids and lipoproteins: a meta-analysis. Am J Clin Nutr 1992; 56: 320-328.
26. Onat A, Turkmen S, Karabulut A, Yazıcı M, Can G, Sansoy V. Combined Hypercholesterolemia and Hypertension Among Turkish Adults: Prevalence and Prediction of Cardiovascular Disease Risk. Arch Turk Soc Cardiol 2004; 32: 533-541.
27. Erem C, Hacihasanoglu A, Kocak M, Deger O, Topbas M. Prevalence of prehypertension and hypertension and associated risk factors among Turkish adults: Trabzon Hypertension Study. Journal of Public Health 2008; 31: 47–58.

APA	ÇETİN İ, YILDIRIM B, ŞAHİN Ş, Şahin İ, Etikan I (2010). Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat. , 771 - 782.
Chicago	ÇETİN İlhan,YILDIRIM Beytullah,ŞAHİN Şemsettin,Şahin İdris,Etikan Ilker Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat. (2010): 771 - 782.
MLA	ÇETİN İlhan,YILDIRIM Beytullah,ŞAHİN Şemsettin,Şahin İdris,Etikan Ilker Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat. , 2010, ss.771 - 782.
AMA	ÇETİN İ,YILDIRIM B,ŞAHİN Ş,Şahin İ,Etikan I Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat. . 2010; 771 - 782.
Vancouver	ÇETİN İ,YILDIRIM B,ŞAHİN Ş,Şahin İ,Etikan I Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat. . 2010; 771 - 782.
IEEE	ÇETİN İ,YILDIRIM B,ŞAHİN Ş,Şahin İ,Etikan I "Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat." , ss.771 - 782, 2010.
ISNAD	ÇETİN, İlhan vd. "Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat". (2010), 771-782.

APA	ÇETİN İ, YILDIRIM B, ŞAHİN Ş, Şahin İ, Etikan I (2010). Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat. Turkish Journal of Medical Sciences, 40(5), 771 - 782.
Chicago	ÇETİN İlhan,YILDIRIM Beytullah,ŞAHİN Şemsettin,Şahin İdris,Etikan Ilker Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat. Turkish Journal of Medical Sciences 40, no.5 (2010): 771 - 782.
MLA	ÇETİN İlhan,YILDIRIM Beytullah,ŞAHİN Şemsettin,Şahin İdris,Etikan Ilker Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat. Turkish Journal of Medical Sciences, vol.40, no.5, 2010, ss.771 - 782.
AMA	ÇETİN İ,YILDIRIM B,ŞAHİN Ş,Şahin İ,Etikan I Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat. Turkish Journal of Medical Sciences. 2010; 40(5): 771 - 782.
Vancouver	ÇETİN İ,YILDIRIM B,ŞAHİN Ş,Şahin İ,Etikan I Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat. Turkish Journal of Medical Sciences. 2010; 40(5): 771 - 782.
IEEE	ÇETİN İ,YILDIRIM B,ŞAHİN Ş,Şahin İ,Etikan I "Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat." Turkish Journal of Medical Sciences, 40, ss.771 - 782, 2010.
ISNAD	ÇETİN, İlhan vd. "Serum lipid and lipoprotein levels, dyslipidemia prevalence, and the factors that influence these parameters in a Turkish population living in the province of Tokat". Turkish Journal of Medical Sciences 40/5 (2010), 771-782.