Introduction: In this study, we aimed to retrospectively examine the demographic and clinical characteristics of patients who are followed up in the intensive care unit due to acute drug intoxication. Materials and Methods: In our study, the demographic characteristics of adolescent patients treated with the diagnosis of acute drug intoxication in the intensive care unit; a history of psychiatric illness; intensive care unit stay; Glasgow Coma Scale; the content and number of the substance or substances causing the intoxication; the reason and type of toxic substance ingestion; whether it is a single drug or multiple drugs; the period (months) of intoxication and mortality characteristics were examined. Results: A total of 181 patients, 100 (55.2%) male and 81 (44.8%) female, were included in the study, and the mean age of the patients was 29.58 ± 16.11 (min= 14, max=88). It was found that 154 (84.1%) of the intoxications were due to medical drugs, 137 (75.7%) of them were suicidal. It was determined that 68.5% of the substances causing intoxication were in toxic dose and the most common antidepressant (n=38.21.0%), analgesic (n=27.14.9%), antiepileptic drugs (n=16, 8.8%). 86 of the patients (47.5%) had at least one psychiatric illness and 51 (28.2%) had systemic disease. It was determined that the most frequent intoxications occurred in spring (33.1%) and at least in summer (16.6%), 114 (63.0%) were discharged and 4 (2.2%) died. Conclusion: It was found that acute drug intoxications were mostly seen in patients with psychiatric disease and that suicidal intoxications occurred with the medical drugs used by patients themselves. For these reasons, it was concluded that the presence of psychiatric disease is important in drug intoxication cases admitted to the ICU.