Objectives: This descriptive study was planned to determine the conscience perceptions of nurses working in pandemic hospitals. Methods: The study population comprised all nurses working in Sivas Numune Hospital. A personal information form and the Conscience Perception scale were used in the study. The convenience sampling method was applied, the data collection forms were uploaded to the system and a link was created. The forms were thus sent to the nurses for online completion. Informed consent was provided by the nurses and the necessary ethical and official permissions were obtained. Results: The majority of the nurses participating in the study (95%) were female, married (66.7%), with a university degree (46.9%), and work experience of 21 years or more (35.8%). The conscience perceptions of the female nurses working during the pandemic were determined to be statistically significantly high. The education level of the nurses significantly affected the perception of conscience, with a higher level of conscience perception shown by nurses with a bachelor's degree. The conscience perception scale sub-dimension of the clinic where they worked showed a significant difference in terms of authority. There was a statistically significant increase in the authority sub-dimension of nurses working in the operating room / intensive care unit. Conclusion: Working conditions and risks affected the conscience perceptions of professional responsibility and sensitivity of nurses who had to remain separated from their families during the COVID-19 pandemic.