Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?

DOGANAY, Songul; tanyeli, ayhan; guler, mustafa can; Eraslan, Ersen; Güzel Erdoğan, Derya

doi:10.31832/smj.787082

Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?

Derya GÜZEL ERDOĞAN, (Sakarya Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Sakarya, Türkiye)

Ayhan TANYELİ, (Sakarya Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Sakarya, Türkiye)

Songül DOĞANAY, (Sakarya Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Sakarya, Türkiye)

Mustafa Can GÜLER, (Sakarya Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Sakarya, Türkiye)

Ersen ERASLAN (Yozgat Bozok Üniversitesi, Tıp Fakültesi, Fizyoloji Anabilim Dalı, Yozgat, Türkiye)

Sakarya Tıp Dergisi

1 0

Yıl: 2021 Cilt: 11 Sayı: 1 Sayfa Aralığı: 142 - 147 Metin Dili: İngilizce DOI: 10.31832/smj.787082 İndeks Tarihi: 05-12-2022

Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?

Öz:

Objective: Here, possible protective effects of Urapidil were investigated against lung and renal injuries induced by cecal ligation and puncture (CLP). Materials and Methods: 32 Sprague Dawley male rats were assigned to 4 groups as follows; sham, CLP, DMSO and Urapidil (URA) 0.5 mg/kg. Several oxidant, inflammatory and antioxidant parameters were determined in lung and renal tissues. Results: Oxidant and inflammatory biomarkers increased while antioxidant biomarkers decreased in CLP and DMSO groups compared to sham group. Antioxidant parameters increased while oxidant and inflammatory biomarkers declined in treatment group compared to CLP and DMSO groups. Conclusion: Present results have demonstrated that URA administration is effective against lung and renal injuries caused by CLP-related polymicrobial sepsis model.

Anahtar Kelime: urapidil cecal ligation and puncture lung renal rat

Urapidil Çekal Ligasyon ve Delme ile İndüklenen Akciğer ve Böbrek Hasarını Hafifletir mi?

Öz:

Amaç: Burada, çekal ligasyon ve ponksiyonun (CLP) neden olduğu akciğer ve böbrek yaralanmalarına karşı Urapidil'in olası koruyucu etkileri araştırıldı. Materyal ve Metod: 32 Sprague Dawley erkek sıçan sham, CLP, Dimetil sülfoksit (DMSO) ve Urapidil (URA) 0.5 mg/kg şeklinde 4 gruba ayrıldı. Akciğer ve böbrek dokularında çeşitli oksidan, inflamatuvar ve antioksidan parametreler belirlendi. Bulgular: CLP ve DMSO gruplarında sham grubuna göre oksidan ve inflamatuvar biyobelirteçler artarken antioksidan biyobelirteçler azalmıştır. Tedavi grubunda CLP ve DMSO gruplarına göre antioksidan parametreler artarken oksidan ve inflamatuvar biyobelirteçler azaldı. Sonuç: Mevcut sonuçlar, URA uygulamasının CLP ile ilişkili polimikrobiyal sepsis modelinin neden olduğu akciğer ve böbrek hasarlarına karşı etkili olduğunu göstermiştir.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Güzel Erdoğan D, tanyeli a, DOGANAY S, guler m, Eraslan E (2021). Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?. , 142 - 147. 10.31832/smj.787082
Chicago	Güzel Erdoğan Derya,tanyeli ayhan,DOGANAY Songul,guler mustafa can,Eraslan Ersen Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?. (2021): 142 - 147. 10.31832/smj.787082
MLA	Güzel Erdoğan Derya,tanyeli ayhan,DOGANAY Songul,guler mustafa can,Eraslan Ersen Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?. , 2021, ss.142 - 147. 10.31832/smj.787082
AMA	Güzel Erdoğan D,tanyeli a,DOGANAY S,guler m,Eraslan E Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?. . 2021; 142 - 147. 10.31832/smj.787082
Vancouver	Güzel Erdoğan D,tanyeli a,DOGANAY S,guler m,Eraslan E Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?. . 2021; 142 - 147. 10.31832/smj.787082
IEEE	Güzel Erdoğan D,tanyeli a,DOGANAY S,guler m,Eraslan E "Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?." , ss.142 - 147, 2021. 10.31832/smj.787082
ISNAD	Güzel Erdoğan, Derya vd. "Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?". (2021), 142-147. https://doi.org/10.31832/smj.787082

APA	Güzel Erdoğan D, tanyeli a, DOGANAY S, guler m, Eraslan E (2021). Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?. Sakarya Tıp Dergisi, 11(1), 142 - 147. 10.31832/smj.787082
Chicago	Güzel Erdoğan Derya,tanyeli ayhan,DOGANAY Songul,guler mustafa can,Eraslan Ersen Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?. Sakarya Tıp Dergisi 11, no.1 (2021): 142 - 147. 10.31832/smj.787082
MLA	Güzel Erdoğan Derya,tanyeli ayhan,DOGANAY Songul,guler mustafa can,Eraslan Ersen Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?. Sakarya Tıp Dergisi, vol.11, no.1, 2021, ss.142 - 147. 10.31832/smj.787082
AMA	Güzel Erdoğan D,tanyeli a,DOGANAY S,guler m,Eraslan E Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?. Sakarya Tıp Dergisi. 2021; 11(1): 142 - 147. 10.31832/smj.787082
Vancouver	Güzel Erdoğan D,tanyeli a,DOGANAY S,guler m,Eraslan E Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?. Sakarya Tıp Dergisi. 2021; 11(1): 142 - 147. 10.31832/smj.787082
IEEE	Güzel Erdoğan D,tanyeli a,DOGANAY S,guler m,Eraslan E "Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?." Sakarya Tıp Dergisi, 11, ss.142 - 147, 2021. 10.31832/smj.787082
ISNAD	Güzel Erdoğan, Derya vd. "Does urapidil alleviate lung and renal injuries induced by cecal ligation and puncture?". Sakarya Tıp Dergisi 11/1 (2021), 142-147. https://doi.org/10.31832/smj.787082