Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication

Ataseven, Hilmi; DEMIR, MEHMET

Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication

Mehmet DEMİR, (Erzurum Bölge Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, Erzurum, Türkiye)

Hilmi ATASEVEN (Erzurum Bölge Eğitim ve Araştırma Hastanesi, Gastroenteroloji Kliniği, Erzurum, Türkiye)

Turkish Journal of Medical Sciences

2 0

Yıl: 2011 Cilt: 41 Sayı: 3 Sayfa Aralığı: 427 - 433 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication

Öz:

Amaç: Ülkemizde Helicobacter pylori (HP) için etkili eradikasyon rejimi yoktur. Son dönemlerdeki bilgiler HP eradikasyonu için ardışık tedavi rejimininin standart üçlü tedaviden üstün olduğunu göstermiştir. Bizim bu çalışmadaki amacımız HP eradikasyonu için birinci basamak tedavi olarak 14 günlük ardışık tedavi rejiminin etkinliğini araştırmaktı. Yöntem ve gereç: Bu çalışma prospektif, open-label, tek merkezli bir çalışmadır. Çalışmaya ardışık 86 nonülser dispepsili hasta dahil edildi. Tüm hastalar rastgele 2 çalışma grubuna 2:1 oranında rastgele örnekleme sayıları kullanarak ayrıldı. İlk gruptaki hastalara ardışık tedavi verildi; pantoprazol 2 × 40 mg ve amoksisiklin 2 × 1000 mg ilk 7 gün, ve pantoprazol 2 × 40 mg, metronidazol 2 × 500 mg, tetrasiklin 4 × 500 mg geriye kalan 7 gün. İkinci gruptaki hastalara pantoprazol 2 × 40 mg ve amoksisiklin 2 × 1000 mg ve klaritromisin 2 × 500 mg (PAC) verildi. Bulgular: Ardışık gurupta eradikasyon oranı ITT analizi ile % 56,1 ve PP analizi ile %,57,1, PAC grupta hem ITT hem de PP analizi ile % 58,6 idi, ve gruplar arasında hem ITT hem de PP analizi ile istatistiksel olarak anlamlı fark yoktu. Gruplar arasında yan etki açısından istatistiksel olarak anlamlı fark yoktu (% 10,5 karşın % 13,8 P > 0,05).Sonuç: Bu sonuçlar HP eradikasyonu için birinci basamak tedavi olarak 14 günlük ardışık tedavi rejiminin etkin olmadığını düşündürmektedir.

Anahtar Kelime:

Konular: Cerrahi

Helicobacter pylori eradikasyonu için birinci basamak tedavi olarak ardışık tedavi rejiminin etkinliği

Öz:

Aim: Th ere is no eff ective eradication regimen for Helicobacter pylori (HP) in Turkey. Recent studies have shown that sequential therapy may be superior to the standard triple therapy in terms of the eradication of HP. In this study, we aim to assess the effi cacy of a 14-day sequential treatment regimen as a fi rst-line therapy for HP eradication. Materials and methods: Th is is a prospective, open-label, single-centre study. Th e study involved 86 consecutive patients with nonulcer dyspepsia. All patients were randomly assigned into 2 study groups at a 2:1 ratio using random sampling numbers. Th e fi rst group of patients were administered a sequential treatment: pantoprazole 2 × 40 mg and amoxicillin 2 × 1000 mg for the fi rst 7 days and pantoprazole 2 × 40 mg, metronidazole 2 × 500 mg, and tetracycline 4 × 500 mg for the remaining 7 days. Th e second group of patients were administered pantoprazole 2 × 40 mg, amoxicillin 2 × 1000 mg, and clarithromycin 2 × 500 mg (PAC) for 14 days. Eradication was defi ned as the absence HP as assessed with the (14-C) urea breath test 4 weeks aft er the end of the antimicrobial therapy. Results: Th e eradication rate in the sequential group was 56.1% for the ITT analysis and 57.1% for the PP analysis, the eradication rate of the PAC group was 58.6 % for both PP and ITT analysis. Th ere was a statistically signifi cant diff erence between the eradication rates of the groups for both PP and ITT analysis. Th ere was no statistically signifi cant diff erence in the adverse eff ects encountered in both groups (10.5% versus 13.8% P > 0.05). Conclusion: Th ese results suggest that a 14-day sequential eradication regimen is not eff ective as a fi rst-line therapy for HP eradication.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	DEMIR M, Ataseven H (2011). Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication. , 427 - 433.
Chicago	DEMIR MEHMET,Ataseven Hilmi Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication. (2011): 427 - 433.
MLA	DEMIR MEHMET,Ataseven Hilmi Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication. , 2011, ss.427 - 433.
AMA	DEMIR M,Ataseven H Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication. . 2011; 427 - 433.
Vancouver	DEMIR M,Ataseven H Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication. . 2011; 427 - 433.
IEEE	DEMIR M,Ataseven H "Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication." , ss.427 - 433, 2011.
ISNAD	DEMIR, MEHMET - Ataseven, Hilmi. "Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication". (2011), 427-433.

APA	DEMIR M, Ataseven H (2011). Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication. Turkish Journal of Medical Sciences, 41(3), 427 - 433.
Chicago	DEMIR MEHMET,Ataseven Hilmi Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication. Turkish Journal of Medical Sciences 41, no.3 (2011): 427 - 433.
MLA	DEMIR MEHMET,Ataseven Hilmi Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication. Turkish Journal of Medical Sciences, vol.41, no.3, 2011, ss.427 - 433.
AMA	DEMIR M,Ataseven H Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication. Turkish Journal of Medical Sciences. 2011; 41(3): 427 - 433.
Vancouver	DEMIR M,Ataseven H Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication. Turkish Journal of Medical Sciences. 2011; 41(3): 427 - 433.
IEEE	DEMIR M,Ataseven H "Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication." Turkish Journal of Medical Sciences, 41, ss.427 - 433, 2011.
ISNAD	DEMIR, MEHMET - Ataseven, Hilmi. "Th e eff ects of sequential treatment as a fi rst-line therapy for Helicobacter pylori eradication". Turkish Journal of Medical Sciences 41/3 (2011), 427-433.