Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats
Yıl: 2022 Cilt: 3 Sayı: 1 Sayfa Aralığı: 16 - 20 Metin Dili: İngilizce DOI: 10.14744/hf.2021.2021.0040 İndeks Tarihi: 12-05-2023
Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats
Öz: Background and Aim: In this study, we aimed to assess the hemostatic and histopathological impacts of the Algan hemostatic agent (AHA) with the liver injury model. Materials and Methods: 24 male rats, 10-12 week old, were randomly divided into three equal groups (n=8) as control (physiological saline solu- tion), AHA liquid and AHA powder. A total of three iatrogenic cut injuries were performed on the anterior surface of the left liver lobe. After bleeding started, sponges soaked with physiological saline, AHA liquid, AHA pow- der were gently pressed on the injured area for 20 seconds in corresponding groups, respectively. The bleeding time was measured with a timer. Failure to stop bleeding after three consecutive applications was considered as a failure. Animals were euthanized at the tenth minute of the procedure. Left liver lobes were removed for histopathological examination. Results: Bleeding control success rates of AHA liquid were significantly higher than that of the AHA powder group, and both forms were more effec- tive than physiological saline. A superficial thick granulation tissue with en- trapped powder residual materials was detected in the AHA powder group. Liver parenchyma was intact in liquid and powder groups. Conclusion: AHA is a fast-acting and applicable hemostatic agent in the liver bleeding model. However, further comparative studies in various or- gans are needed.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA | Şener Akçora D, Koçak M, Saraçoğlu R, Deveci U, Karadağ M (2022). Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats. , 16 - 20. 10.14744/hf.2021.2021.0040 |
Chicago | Şener Akçora Dila,Koçak Mihrican,Saraçoğlu Ramazan,Deveci Ugur,Karadağ Mehmet Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats. (2022): 16 - 20. 10.14744/hf.2021.2021.0040 |
MLA | Şener Akçora Dila,Koçak Mihrican,Saraçoğlu Ramazan,Deveci Ugur,Karadağ Mehmet Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats. , 2022, ss.16 - 20. 10.14744/hf.2021.2021.0040 |
AMA | Şener Akçora D,Koçak M,Saraçoğlu R,Deveci U,Karadağ M Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats. . 2022; 16 - 20. 10.14744/hf.2021.2021.0040 |
Vancouver | Şener Akçora D,Koçak M,Saraçoğlu R,Deveci U,Karadağ M Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats. . 2022; 16 - 20. 10.14744/hf.2021.2021.0040 |
IEEE | Şener Akçora D,Koçak M,Saraçoğlu R,Deveci U,Karadağ M "Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats." , ss.16 - 20, 2022. 10.14744/hf.2021.2021.0040 |
ISNAD | Şener Akçora, Dila vd. "Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats". (2022), 16-20. https://doi.org/10.14744/hf.2021.2021.0040 |
APA | Şener Akçora D, Koçak M, Saraçoğlu R, Deveci U, Karadağ M (2022). Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats. Hepatology forum, 3(1), 16 - 20. 10.14744/hf.2021.2021.0040 |
Chicago | Şener Akçora Dila,Koçak Mihrican,Saraçoğlu Ramazan,Deveci Ugur,Karadağ Mehmet Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats. Hepatology forum 3, no.1 (2022): 16 - 20. 10.14744/hf.2021.2021.0040 |
MLA | Şener Akçora Dila,Koçak Mihrican,Saraçoğlu Ramazan,Deveci Ugur,Karadağ Mehmet Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats. Hepatology forum, vol.3, no.1, 2022, ss.16 - 20. 10.14744/hf.2021.2021.0040 |
AMA | Şener Akçora D,Koçak M,Saraçoğlu R,Deveci U,Karadağ M Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats. Hepatology forum. 2022; 3(1): 16 - 20. 10.14744/hf.2021.2021.0040 |
Vancouver | Şener Akçora D,Koçak M,Saraçoğlu R,Deveci U,Karadağ M Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats. Hepatology forum. 2022; 3(1): 16 - 20. 10.14744/hf.2021.2021.0040 |
IEEE | Şener Akçora D,Koçak M,Saraçoğlu R,Deveci U,Karadağ M "Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats." Hepatology forum, 3, ss.16 - 20, 2022. 10.14744/hf.2021.2021.0040 |
ISNAD | Şener Akçora, Dila vd. "Histopathological effects of Algan hemostatic agent (AHA) in liver injury model in rats". Hepatology forum 3/1 (2022), 16-20. https://doi.org/10.14744/hf.2021.2021.0040 |