Yıl: 2022 Cilt: 28 Sayı: 2 Sayfa Aralığı: 39 - 45 Metin Dili: İngilizce DOI: 10.4274/vhd.galenos.2022.2022-3-1 İndeks Tarihi: 22-05-2023

Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections

Öz:
Objectives: Viral hepatitis and human immunodeficiency virus (HIV) infections are still significant causes of morbidity and mortality. This study investigatedaimed to investigate the effect of hepatitis B virus (HBV) and hepatitis C virus (HCV) infection on HIV infection, investigate the epidemiological characteristics of co-infected patients and thus help identify risk factors for co- infection, evaluate the results and clinical information, and shape the treatment of patients. Materials and Methods: This descriptive, cross-sectional study from January 2013 to July 2021 was conducted carried out on 758 patients, including 502 infected with HIV, 196 co-infected with HBV/HCV, and 60 co-infected with HCV/HIV. Comparison between groups in terms of categorical characteristics was analyzed with the Pearson chi-square test or Fisher-Freeman-Halton test. The changes in HIV infection in the presence of co-infections were examined with the multivariate multinomial logistic regression model. Results: We found differences in our HIV-infected patients co- infected with HBV or HCV in gender, nationality, transmission routes, HIV viral load, and CD+4 T-cell count (p<0.001). There was no difference between the groups regarding age, opportunistic infection status, and malignancy status. Conclusion: Our findings indicate that HBV and HCV may affect HIV infection infections. Our approach can focus on these points in co-infected patients, and we can effectively manage their treatment and follow-up.
Anahtar Kelime: Human immunodeficiency virus hepatitis B virus hepatitis C virus co-infection

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Fauci AS, Morens DM. The perpetual challenge of infectious diseases. N Engl J Med. 2012;366:454-461.
  • World Health Organisation. (Accessed on 17 September 2021). www. who.int/gho/hepatitis/epidemic_status/en/2017
  • UNAIDS Data. 2019. (Accessed September 17, 2021). Available at: https://www.unaids.org/sites/default/files/media_asset/2019-UNAIDS- data_en.pdf2017
  • Gündüz A. HIV Coinfections (HBV coinfection, HCV coinfection) Turkiye Klinikleri J Inf Dis-Special Topics. 2016;9:79-86.
  • Prussing C, Chan C, Pinchoff J, Kersanske L, Bornschlegel K, Balter S, Drobnik A, Fuld J. HIV and viral hepatitis co-infection in New York City, 2000-2010: prevalence and case characteristics. Epidemiol Infect. 2015;143:1408-1416.
  • Alter MJ. Epidemiology of viral hepatitis and HIV co-infection. J Hepatol. 2006;44:6-9.
  • Puglia M, Stasi C, Frè MD, Voller F. Prevalence and characteristics of HIV/HBV and HIV/HCV coinfections in Tuscany Braz J Infect Dis. 2016;20:330-334.
  • Toy M, Önder FO, Wörmann T, Bozdayi AM, Schalm SW, Borsboom GJ, van Rosmalen J, Richardus JH, Yurdaydin C. Age- and region-specific hepatitis B prevalence in Turkey estimated using generalized linear mixed models: a systematic review. BMC Infect Dis. 2011;11:337.
  • Bruggman P, Berg T, Ourehius AC, Moreno C, Brandao C, Mello CE, Roudot-Thoraval F, Marinho RT, Sherman M, Ryder SD, Sperl J, Akarca U, Balık I, Bihl F, Bilodeau M, Blasco AJ, Buti M, Calinas F, Calleja JL, Cheinquer H, Christensen PB, Clausen M, Coelho HS, Cornberg M, Cramp ME, Dore GJ, Doss W, Duberg AS, El-Sayed MH, Ergör G, Esmat G, Estes C, Falconer K, Félix J, Ferraz ML, Ferreira PR, Frankova S, García-Samaniego J, Gerstoft J, Giria JA, Gonçales FL Jr, Gower E, Gschwantler M, Guimarães Pessôa M, Hézode C, Hofer H, Husa P, Idilman R, Kåberg M, Kaita KD, Kautz A, Kaymakoglu S, Krajden M, Krarup H, Laleman W, Lavanchy D, Lázaro P, Marotta P, Mauss S, Mendes Correa MC, Müllhaupt B, Myers RP, Negro F, Nemecek V, Örmeci N, Parkes J, Peltekian KM, Ramji A, Razavi H, Reis N, Roberts SK, Rosenberg WM, Sarmento-Castro R, Sarrazin C, Semela D, Shiha GE, Sievert W, Stärkel P, Stauber RE, Thompson AJ, Urbanek P, van Thiel I, Van Vlierberghe H, Vandijck D, Vogel W, Waked I, Wedemeyer H, Weis N, Wiegand J, Yosry A, Zekry A, Van Damme P, Aleman S, Hindman SJ. Historical epidemiology of hepatitis C virus (HCV) in selected countries. J Viral Hepat. 2014;21:5-33.
  • The Republic of Turkey MoH, General Directorate of Public Health, HIV/AIDS Statistics report 2019. (Accessed September 17, 2021). Available at: https://hsgm.saglik.gov.tr/tr/bulasici-hastaliklar/hiv-aids/hiv- aidsliste/h%C4%B1v-aids-istatislik.html
  • Fincancı M, Aydin OA, Yemisen M, Karaosmanoglu HK, Sargin F, Gunduz A, Ceylan B, Mete B, Ozgunes N, Sevgi DY, Ozaras R, Tabak F. Low Prevalence of Hepatitis C Virus Infection Among HIV-Positive Patients: Data From a Large-Scale Cohort Study in Istanbul, Turkey. Hepat Mon. 2014;14:e18128.
  • CrowellTA,BerrySA,FleishmanJA,LaRueRW,KorthuisPT,Nijhawanet AE, Moore RD, Gebo KA; HIV Research Network. Impact of hepatitis co-infection on healthcare utilization among persons living with HIV. J Acquir Immune Defic Syndr. 2015;68:425-431.
  • Singh KP, Crane M, Audsley J, Avihingsanon A, Sasadeusz J, Lewin SR. HIV-hepatitis B virus coinfection: epidemiology, pathogenesis, and treatment. AIDS. 2017;31:2035-2052.
  • Chew KW, Bhattacharya D. Virologic and immunologic aspects of HIV- hepatitis C virus coinfection. AIDS. 2016;30:2395-2404.
  • Lee MH, Yang HI, Lu SN, Jen CL, You SL, Wang LY, Wang CH, Chen WJ, Chen CJ; R.E.V.E.A.L.-HCV Study Group. Chronic hepatitis C virus infection increases mortality from hepatic and extrahepatic diseases: a community-based long-term prospective study. J Infect Dis. 2012;206:469-477.
  • Karageorgopoulos DE, Allen J, Bhagani S. Hepatitis C in human immunodeficiency virus co-infected individuals: Is this still a “special population?” World J Hepatol. 2015;7:1936-1952.
  • Meissner EG. Update in HIV-hepatitis C virus coinfection in the direct- acting antiviral era. Cur Opin Gastroenterol. 2017;33:120-127.
  • Konopnicki D, Mocroft A, Wit S, Antunes F, Ledergerber B, Katlama C, Zilmer K, Vella S, Kirk O, Lundgren JD; EuroSIDA Group. Hepatitis B, and HIV: prevalence, AIDS progression, response to highly active antiretroviral therapy and increased mortality in the EuroSIDA cohort. AIDS. 2005;19:593-601.
  • Rockstroh JK, Peters L, Grint D, Soriano V, Reiss P, Monforte Ad, Beniowski M, Losso MH, Kirk O, Kupfer B, Mocroft A; EuroSIDA in EuroCoord. Does hepatitis C viremia or genotype predict mortality risk in individuals co-infected with HIV? J Hepatol. 2013;59:213-220.
  • Teira R, VACH Study Group. Hepatitis B virus infection predicts mortality of HIV and hepatitis C virus coinfected patients. AIDS. 2013;27:845- 848.
  • Botheju WSP, Zghyer F, Mahmud S, Terlikbayeva A, El-Bassel N, Abu-Raddad. The epidemiology of hepatitis C virus in Central Asia: Systematic review, meta-analyses, and meta-regression analyses LJ. Sci Rep. 2019;9:2090.
  • Torne C, Ferencic N, Malyuta R, Mimica J, Niemiec, T. Central Asia: hotspot in the worldwide HIV epidemic. Lancet Infect Dis. 2010;10:479- 488.
  • Mohd Hanafah, K, Groeger, J, Flaxman, AD, Wiersma, ST. Global epidemiology of hepatitis C virus infection: New estimates of age specific antibody to HCV seroprevalence. Hepatology. 2013;57:1333-1342.
  • Gower E, Estes C, Blach S, Razavi-Shearer K, Razavi H. Global epidemiology and genotype distribution of the hepatitis C virus infection. J Hepatol. 2014;61:4-57. (Accessed October 2, 2021). https://www.who.int/en/news-room/fact- sheets/detail/hepatitis-c
  • Nelson PK, Mathers BM, Cowie B, Hagan H, Jarlais DD, Danielle Horyniak D, Degenhardt L. Global epidemiology of hepatitis B and hepatitis C in people who inject drugs: results of systematic reviews. Lancet. 2011;378:571-583.
  • LiY,ZhangL,XiaoJ,JiangTY,LiuZY.Epidemiologyandinfluencingfactors of human immunodeficiency virus and hepatitis B virus co-infected patients in Beijing. Zhonghua Nei Ke Za Zhi. 2021;60:233-238.
  • Ojide CK, Kalu EI, Ogbaini-Emevon E, Nwadike VU. Coinfections of hepatitis B and C with human immunodeficiency virus among adult patients attending human immunodeficiency virus outpatients clinic in Benin City, Nigeria, Niger J Clin Pract. 2015;18:516-521.
  • Nagu TJ, Bakari M, Matee M. Hepatitis A, B, and C viral coinfections among HIVinfected adults presenting for care and treatment at Muhimbili National Hospital in Dar es Salaam, Tanzania. BMC Public Health. 2008;8:416.
  • Wu S, P Yan P, Yang T, Wang Z, Yan Y. Epidemiological profile and risk factors of HIV and HBV/HCV co-infection in Fujian Province, southeastern China J Med Virol. 2017;89:443-449.
  • Yıldırım FS, User Ü, Sayan M, Öztoprak N. Does Pegylated-Interferon Still Have High Efficacy Treatment Properties Against Chronic Hepatitis B? Viral Hepat J. 2018;24:90-95.
  • Sarıgul F, Sayan M, User U, Oztoprak N. Evaluation of Direct Acting Antivirals Efficiency in Turkish Patients with Chronic Hepatitis C Under Strict Rules. Hepat Mon. 2019;19:e62390.
  • Zhang X, Wang C, Hengwei W, Li X, Li D, Ruan Y, Zhang X, Shao Y. Risk factors of HIV infection and prevalence of co-infection among men who have sex with men in Beijing, China. AIDS. 2007;21:53-57.
  • Battjes RJ, Pickens RW, Haverkos HW, Sloboda Z. HIV risk factors among injecting drug users in five US cities. AIDS. 1994;8:681-687.
  • Bagheri Amiri F, Mostafavi E, Mirzazadeh A. HIV, HBV and HCV Coinfection Prevalence in Iran--A Systematic Review and Meta- Analysis. PLoS One. 2016;11:e0151946
  • Cieply L, Simmons R, Ijaz S, Kara E, Rodger A, Rosenberg W, McGuinness A, Mbisa JL, Ledesma J, Ohemeng-Kumi N, Dicks S, Potts H, Lattimore S, Mandal S. Seroprevalence of HCV, HBV and HIV in two inner-city London emergency departments. Epidemiol Infect. 2019;147:e145.
  • Davlidova S, Haley-Johnson Z, Nyhan K, Farooq A, Vermund SH, Ali S. Prevalence of HIV, HCV and HBV in Central Asia and the Caucasus: A systematic review. Int J Infect Dis. 2021;104:510-525.
  • Ganesan M, Poluektova LY, Kharbanda KK, Osna NA. Human immunodeficiency virus and hepatotropic viruses co-morbidities as the inducers of liver injury progression World J Gastroenterol. 2019;25:398- 410.
  • Scharschmidt BF, Held MJ, Hollander HH, Read AE, Lavine JE, Veereman G, McGuire RF, Thaler MM. Hepatitis B in patients with HIV infection: relationship to AIDS patient survival. Ann Intern Med. 1992;117:837-838.
  • Sinicco A, Raiteri R, Sciandra M, Bertone C, Lingua A, Salassa B, Gioannini P. Co-infection and superinfection of hepatitis B virus in patients infected with human immunodeficiency virus: no evidence of faster progression to AIDS. Scand J Infect Dis. 1997;29:111-115.
  • Gilson RJ, Hawkins AE, Beecham MR, Ross E, Waite J, Briggs M, McNally T, Kelly GE, Tedder RS, Weller IV. Interactions between HIV and hepatitis B virus in homosexual men: effects on the natural history of infection. AIDS. 1997;11:597-606.
  • Ockenga J, Tillmann HL, Trautwein C, Stoll M, Manns MP, Schmidt RE. Hepatitis B and C in HIV-infected patients. Prevalence and prognostic value. J Hepatol. 1997;27:18-24.
  • Eskild A, Magnus P, Petersen G, Sohlberg C, Jensen F, Kittelsen P, Skaug K. Hepatitis B antibodies in HIV-infected homosexual men are associated with more rapid progression AIDS. AIDS. 1992;6:571-574.
  • Wandeler G, Gsponer T, Bihl F, Bernasconi E, Cavassini M, Kovari H, Schmid P, Battegay M, Calmy A, Egger M, Furrer H, Rauch A; Swiss HIV Cohort Study. Hepatitis B virus infection is associated with impaired immunological recovery during antiretroviral therapy in the Swiss HIV cohort study. J Infect Dis. 2013;208:1454-1458.
  • Malagnino V, Cerva C, Teti E, Campogiani L, Compagno M, Foroghi, et al. Poor CD4/CD8 ratio recovery in HBcAb-positive HIV patients with worse immune status is associated with significantly higher CD8 cell numbers. Sci Rep. 2021;11:3965.
  • Chun HM, Roediger MP, Hullsiek KH, Thio CL, Agan BK, Bradley WP, Peel SA, Jagodzinski LL, Weintrob AC, Ganesan A, Wortmann G, CrumCianflone NF, Maguire JD, Landrum ML; Infectious Disease Clinical Research Program HIV Working Group. Hepatitis B Virus Coinfection Negatively Impacts HIV Outcomes in HIV Seroconverters J Infect Dis. 2012;205:185-193.
  • Körner C, Tolksdorf F, Schulte D, Krämer B, Schulte D, Nattermann J, Rockstroh JK, Spengler U. Hepatitis C coinfection enhances sensitization of CD4 (1) T-cells towards Fas-induced apoptosis in viraemic and HAART-controlled HIV-1-positive patients. Antivir Ther. 2011;16:1047-1055.
  • Kovacs A, Karim R, Mack WJ, Xu J, Chen Z, Eva Operskalski E, Frederick T, Landay A, Voris J, Spencer LS, Young MA, Tien PC, Augenbraun M, Strickler HD, Al-Harthi L. Activation of CD8 T cells predicts progression of HIV infection in women coinfected with hepatitis C virus. J Infect Dis. 2010;201:823-834.
  • Potter M, Odueyungbo A, Yang H, Saeed S, Klein MB; Canadian Co-infection Cohort Study Investigators. Impact of hepatitis C viral replication on CD41 T-lymphocyte progression in HIV-HCV coinfection before and after antiretroviral therapy. AIDS. 2010;24:1857-1865.
  • Lee HC, Sung SS, Krueger PD, Jo YA, Rosen HR, Ziegler SF, Hahn YS. Hepatitis C virus promotes T-helper (Th)17 responses through thymic stromal lymphopoietin production by infected hepatocytes. Hepatology. 2013;57:1314-1324.
  • Díaz-Muñoz SL. Viral coinfection is shaped by host ecology and virus- virus interactions across diverse microbial taxa and environments. Virus Evol. 2017;3:vex011.
  • Kotsafti O, Paparizos V, Kourkounti S, Chatziioannou A, Nicolaidou E, Kapsimali V, Antoniou C. Early syphilis affects markers of HIV infection. Int J STD AIDS. 2016;27:739-745.
  • Sarıgül F, Sayan M, İnan D, Deveci A, Ceran N, Çelen MK, Çağatay A, Özdemir HÖ, Kuşcu F, Karagöz G, Heper Y, Karabay O, Dokuzoğuz B, Kaya S, Erben N, Karaoğlan İ, Ersöz GM, Günal Ö, Hatipoğlu Ç, Kutlu SS, Akbulut A, Saba R, Şener A, Büyüktuna SA. Current status of HIV/ AIDS-syphilis co-infections: a retrospective multicentre study. Cent Eur J Public Health. 2019;27:223-228.
  • Sarıgül F, Üser Ü, Öztoprak N. Seroprevalence and Risk Factors in HIV/ AIDS Patients Coinfected With Syphilis. Klimik Dergisi 2019;32:161- 164.
  • Ozkan ÖH, Tosun S, Bozaci İ. Risk Factors and seroprevalence of Syphilis Among Naive HIV Patients: A Cross-Sectional Study From a Tertiary Center. Med Bull Haseki. 2021;59:313-318.
APA Sarıgül F, SAYAN M (2022). Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections. , 39 - 45. 10.4274/vhd.galenos.2022.2022-3-1
Chicago Sarıgül Figen,SAYAN MURAT Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections. (2022): 39 - 45. 10.4274/vhd.galenos.2022.2022-3-1
MLA Sarıgül Figen,SAYAN MURAT Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections. , 2022, ss.39 - 45. 10.4274/vhd.galenos.2022.2022-3-1
AMA Sarıgül F,SAYAN M Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections. . 2022; 39 - 45. 10.4274/vhd.galenos.2022.2022-3-1
Vancouver Sarıgül F,SAYAN M Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections. . 2022; 39 - 45. 10.4274/vhd.galenos.2022.2022-3-1
IEEE Sarıgül F,SAYAN M "Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections." , ss.39 - 45, 2022. 10.4274/vhd.galenos.2022.2022-3-1
ISNAD Sarıgül, Figen - SAYAN, MURAT. "Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections". (2022), 39-45. https://doi.org/10.4274/vhd.galenos.2022.2022-3-1
APA Sarıgül F, SAYAN M (2022). Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections. Viral Hepatitis Journal, 28(2), 39 - 45. 10.4274/vhd.galenos.2022.2022-3-1
Chicago Sarıgül Figen,SAYAN MURAT Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections. Viral Hepatitis Journal 28, no.2 (2022): 39 - 45. 10.4274/vhd.galenos.2022.2022-3-1
MLA Sarıgül Figen,SAYAN MURAT Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections. Viral Hepatitis Journal, vol.28, no.2, 2022, ss.39 - 45. 10.4274/vhd.galenos.2022.2022-3-1
AMA Sarıgül F,SAYAN M Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections. Viral Hepatitis Journal. 2022; 28(2): 39 - 45. 10.4274/vhd.galenos.2022.2022-3-1
Vancouver Sarıgül F,SAYAN M Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections. Viral Hepatitis Journal. 2022; 28(2): 39 - 45. 10.4274/vhd.galenos.2022.2022-3-1
IEEE Sarıgül F,SAYAN M "Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections." Viral Hepatitis Journal, 28, ss.39 - 45, 2022. 10.4274/vhd.galenos.2022.2022-3-1
ISNAD Sarıgül, Figen - SAYAN, MURAT. "Implications of Hepatitis B and C on the Human Immunodeficiency Virus Infections". Viral Hepatitis Journal 28/2 (2022), 39-45. https://doi.org/10.4274/vhd.galenos.2022.2022-3-1