Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats

KOÇAK, YILMAZ; mercan yücel, ufuk

doi:10.5505/ejm.2022.64614

Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats

Yılmaz KOÇAK, (Van Yüzüncü Yıl Üniversitesi, Sağlık Bilimleri Fakültesi, Fizik Tedavi ve Rehabilitasyon Anabilim Dalı, Van, TÜRKİYE)

Ufuk Mercan YÜCEL (Van Yüzüncü Yıl Üniversitesi, Veteriner Fakültesi, Farmakoloji-toksikoloji Anabilim Dalı, Van, TÜRKİYE)

Eastern Journal of Medicine

3 1

Yıl: 2022 Cilt: 27 Sayı: 4 Sayfa Aralığı: 649 - 656 Metin Dili: İngilizce DOI: 10.5505/ejm.2022.64614 İndeks Tarihi: 26-05-2023

Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats

Öz:

Liver diseases, morbidity and mortality rates are increasing in the world and existing drugs are insufficient for treatment. For this reason, there has been an increased interest in the discovery of new drugs against liver damage and the search for alternative therapies. This study investigated the cytoprotective and antioxidant effects of Allium schoenoprasum (AS) extract against carbon tetrachloride (CCl4) toxicity in rats. The in vivo experimental procedure was established as follows; Group 1, control (C) animals; Group 2, carboxymethylcellulose (CMC); Group 3, CCl4; Group 4, Legalon (LGL, silymarin); Groups 5, 6 and 7 were treated with AS (100, 200 and 400 mg kg-1) extract only. Groups 8,9 and 10 were administered AS+CCl4. On the 11th day of the experiment, the animals were sacrificed and analyzed . According to the histopathological and biochemical analysis results; It was found that AS extract reduced tissue damage in a dose -dependent manner against CCl4 toxicity. When antioxidant and oxidative biomarkers were examined, positive effects of LGL and AS were observed in correcting the changed oxidant/antioxidant balance status due to oxidative stress caused by CCl 4. The results showed that AS had a dose-dependent hepatoprotective effect against CCl4-induced liver toxicity and it was evaluated that this effect might be due to its antioxidant activity.

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APA	KOÇAK Y, mercan yücel u (2022). Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats. , 649 - 656. 10.5505/ejm.2022.64614
Chicago	KOÇAK YILMAZ,mercan yücel ufuk Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats. (2022): 649 - 656. 10.5505/ejm.2022.64614
MLA	KOÇAK YILMAZ,mercan yücel ufuk Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats. , 2022, ss.649 - 656. 10.5505/ejm.2022.64614
AMA	KOÇAK Y,mercan yücel u Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats. . 2022; 649 - 656. 10.5505/ejm.2022.64614
Vancouver	KOÇAK Y,mercan yücel u Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats. . 2022; 649 - 656. 10.5505/ejm.2022.64614
IEEE	KOÇAK Y,mercan yücel u "Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats." , ss.649 - 656, 2022. 10.5505/ejm.2022.64614
ISNAD	KOÇAK, YILMAZ - mercan yücel, ufuk. "Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats". (2022), 649-656. https://doi.org/10.5505/ejm.2022.64614

APA	KOÇAK Y, mercan yücel u (2022). Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats. Eastern Journal of Medicine, 27(4), 649 - 656. 10.5505/ejm.2022.64614
Chicago	KOÇAK YILMAZ,mercan yücel ufuk Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats. Eastern Journal of Medicine 27, no.4 (2022): 649 - 656. 10.5505/ejm.2022.64614
MLA	KOÇAK YILMAZ,mercan yücel ufuk Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats. Eastern Journal of Medicine, vol.27, no.4, 2022, ss.649 - 656. 10.5505/ejm.2022.64614
AMA	KOÇAK Y,mercan yücel u Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats. Eastern Journal of Medicine. 2022; 27(4): 649 - 656. 10.5505/ejm.2022.64614
Vancouver	KOÇAK Y,mercan yücel u Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats. Eastern Journal of Medicine. 2022; 27(4): 649 - 656. 10.5505/ejm.2022.64614
IEEE	KOÇAK Y,mercan yücel u "Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats." Eastern Journal of Medicine, 27, ss.649 - 656, 2022. 10.5505/ejm.2022.64614
ISNAD	KOÇAK, YILMAZ - mercan yücel, ufuk. "Investigation of Antioxidant and Cytoprotective Effects of Allium Schoenoprasum L (Sirmo) Plant Ethanol Extract in Liver Damage Caused by Carbontetrachloride in Rats". Eastern Journal of Medicine 27/4 (2022), 649-656. https://doi.org/10.5505/ejm.2022.64614