Hyponatremia: More than just an electrolyte for COVID-19 patients
Yıl: 2023 Cilt: 37 Sayı: 2 Sayfa Aralığı: 97 - 109 Metin Dili: İngilizce DOI: 10.18614/detip.1218114 İndeks Tarihi: 20-09-2023
Hyponatremia: More than just an electrolyte for COVID-19 patients
Öz: Aim: Hyponatremia is the most common electrolyte disturbance among infections, especially with pneumonia. Here, we aimed to analyze the presence of hyponatremia among COVID-19 patients along with its relation to the in- hospital mortality. Materials and methods: The patients were divided into two groups COVID-19 negative and positive and also with and without pneumonia. The association between hyponatremia and in-hospital mortality from any cause was evaluated with univariate and multivariate cox regression model. Results: A total of 636 patients, a mean age of 50± 18 years, 48 % of the female with a median duration of hospitalization of 5.5 (IQR, 2,11) days were included. Of those 553 (87%) were detected COVID-19 PCR positive and 298 (47%) of those with pneumonia. The median serum sodium concentration was lower in COVID-19 PCR positive patients [134 (IQR, 130,137) mEq/L] compared to negatives [139 (IQR, 136, 140) mEq/L] (p<0.001). The median serum sodium levels were significantly lower in patients with pneumonia [136 (IQR, 133.138) mEq/L] than without pneumonia [139 (IQR, 137, 145) mEq/L] (p<0.001). All deaths occurred in patients with pneumonia [(n=40 (13.4%)]. Hyponatremia was significantly associated with in-hospital mortality on unadjusted (OR, 3.85, 95%CI: 1.73, 8.53, P<0.001) and adjusted [OR, 3.58, 95% CI: 1.58, 8.1, P=0.002] Cox models. Conclusion: Hyponatremia at admission is prevalent and an independent risk factor for in-hospital mortality among COVID-19 patients particularly those with pneumonia. It might be an important laboratory clue for these patients’ diagnosis and survivals.
Anahtar Kelime: HİPONATREMİ: COVID-19 HASTALARINDA ELEKTROLİTTEN DAHA FAZLASI
Öz: Ortalama yaşı 50± 18 yıl olan 636 hasta çalışmaya dahil edildi. Hastaların % 48'i kadın ve ortanca hastanede yatış süreleri ise 5,5 (IQR, 2,11) gündü. Hastaların 553 (% 87) 'ünde COVID-19 PCR pozitif, ve pozitif hastaların 298'inde (%47) pnömoni saptandı. Ortanca serum sodyum konsantrasyonu COVID-19 PCR pozitif [134 (IQR, 130,137) mEq/L] hastalarda, negatif [139 (IQR, 136, 140) mEq/L] (p<0.001) olan hastalara göre düşük saptandı. COVID-19 PCR pozitif hasta grubu içinde pnömoni hasta grubunda [136 (IQR, 133,138) mEq/L]serum sodyum konsantrasyonu pnömoni olmayan[139 (IQR, 137, 145) mEq/L] (p<0.001) gruba göre istatistiksel olarak anlamlı düzeyde düşük saptandı Tüm ölümler pnömoni ile başvuran hasta grubunda izlendi [(n=40 (%13.4)]. Hiponatremi hem tek değişkenli (OR, 3.85, % 95 CI: 1.73, 8.53, P<0.001) hem de çok değişkenli [OR, 3.58, 95%CI: 1.58, 8.1, P=0.002] Cox regresyon modelinde mortalite için bağımsız bir risk faktörü olduğu görüldü. Tartışma: Hastaneye başvuran COVID-19 PCR pozitif hastalarda özellikle pnömoni saptanan grupta hiponatremi sık görülmekte ve mortalite için bağımsız bir risk faktörü olarak izlenmektedir. Bu hasta grubunda prognozun belirlenmesi açısından hiponatremi önemli bir laboratuvar parametresi olarak görev yapabilir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Deger S, YAŞAR E, ÖZGER H, AYSERT YILDIZ P, BOZTEPE U (2023). Hyponatremia: More than just an electrolyte for COVID-19 patients. , 97 - 109. 10.18614/detip.1218114 |
| Chicago | Deger Serpil Muge,YAŞAR Emre,ÖZGER Hasan Selçuk,AYSERT YILDIZ Pınar,BOZTEPE Ulver Hyponatremia: More than just an electrolyte for COVID-19 patients. (2023): 97 - 109. 10.18614/detip.1218114 |
| MLA | Deger Serpil Muge,YAŞAR Emre,ÖZGER Hasan Selçuk,AYSERT YILDIZ Pınar,BOZTEPE Ulver Hyponatremia: More than just an electrolyte for COVID-19 patients. , 2023, ss.97 - 109. 10.18614/detip.1218114 |
| AMA | Deger S,YAŞAR E,ÖZGER H,AYSERT YILDIZ P,BOZTEPE U Hyponatremia: More than just an electrolyte for COVID-19 patients. . 2023; 97 - 109. 10.18614/detip.1218114 |
| Vancouver | Deger S,YAŞAR E,ÖZGER H,AYSERT YILDIZ P,BOZTEPE U Hyponatremia: More than just an electrolyte for COVID-19 patients. . 2023; 97 - 109. 10.18614/detip.1218114 |
| IEEE | Deger S,YAŞAR E,ÖZGER H,AYSERT YILDIZ P,BOZTEPE U "Hyponatremia: More than just an electrolyte for COVID-19 patients." , ss.97 - 109, 2023. 10.18614/detip.1218114 |
| ISNAD | Deger, Serpil Muge vd. "Hyponatremia: More than just an electrolyte for COVID-19 patients". (2023), 97-109. https://doi.org/10.18614/detip.1218114 |
| APA | Deger S, YAŞAR E, ÖZGER H, AYSERT YILDIZ P, BOZTEPE U (2023). Hyponatremia: More than just an electrolyte for COVID-19 patients. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, 37(2), 97 - 109. 10.18614/detip.1218114 |
| Chicago | Deger Serpil Muge,YAŞAR Emre,ÖZGER Hasan Selçuk,AYSERT YILDIZ Pınar,BOZTEPE Ulver Hyponatremia: More than just an electrolyte for COVID-19 patients. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi 37, no.2 (2023): 97 - 109. 10.18614/detip.1218114 |
| MLA | Deger Serpil Muge,YAŞAR Emre,ÖZGER Hasan Selçuk,AYSERT YILDIZ Pınar,BOZTEPE Ulver Hyponatremia: More than just an electrolyte for COVID-19 patients. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, vol.37, no.2, 2023, ss.97 - 109. 10.18614/detip.1218114 |
| AMA | Deger S,YAŞAR E,ÖZGER H,AYSERT YILDIZ P,BOZTEPE U Hyponatremia: More than just an electrolyte for COVID-19 patients. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi. 2023; 37(2): 97 - 109. 10.18614/detip.1218114 |
| Vancouver | Deger S,YAŞAR E,ÖZGER H,AYSERT YILDIZ P,BOZTEPE U Hyponatremia: More than just an electrolyte for COVID-19 patients. Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi. 2023; 37(2): 97 - 109. 10.18614/detip.1218114 |
| IEEE | Deger S,YAŞAR E,ÖZGER H,AYSERT YILDIZ P,BOZTEPE U "Hyponatremia: More than just an electrolyte for COVID-19 patients." Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi, 37, ss.97 - 109, 2023. 10.18614/detip.1218114 |
| ISNAD | Deger, Serpil Muge vd. "Hyponatremia: More than just an electrolyte for COVID-19 patients". Dokuz Eylül Üniversitesi Tıp Fakültesi Dergisi 37/2 (2023), 97-109. https://doi.org/10.18614/detip.1218114 |
