Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases
Yıl: 2023 Cilt: 17 Sayı: 4 Sayfa Aralığı: 242 - 248 Metin Dili: İngilizce DOI: 10.5578/ced.20239603 İndeks Tarihi: 29-12-2023
Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases
Öz: Objective: Hydatid cyst is a common zoonotic disease caused by echinococcal cestodes. The diagnosis of hydatid cysts is based on clinical symptoms, serology, and radiological findings. There are treatment options such as medical and surgery. In this study, we evaluated the clinical, epidemiological, laboratory, and radiographic findings of pediatric hydatid cysts. Material and Methods: Eighty-four pediatric cases followed between 2012-2022 in our hospital were included. Epidemiological and clinical features of the cases were evaluated. Results: Fifty (59.5%) of the 84 patients were males, and mean age was 137 months. Forty-eight (57.1%) of the patients were from rural areas, and 38 (45.2%) had animal contact. Indirect hemagglutination test was positive in 54.8% of the cases, and 48.8% had eosinophilia. Lung cysts were found in 41.7% of the patients, liver cysts in 32.1%, lung and liver cysts in 23.8% of the patients. Surgery and albendazole treatment were applied in 71.4% of patients, only medical therapy in 25%, and PAIR in one case. While the risk of rupture was higher in patients with lung cysts, IHA positivity was higher in patients with liver cysts. Conclusion: Hydatid cyst continues to be a public health problem for the whole world. Educating the society and taking measures to prevent the spread and transmission are the most important methods of protection. Although it is not a standard treatment regimen, cyst size, location and number are important in the decision of surgery or medical treatment.
Anahtar Kelime: Pediyatrik Kist Hidatik Olgularının Epidemiyolojik ve Klinik Özelliklerinin ve Tedavi Rejimlerinin Değerlendirilmesi
Öz: Giriş: Hidatik kist, ekinokokal sestodların neden olduğu yaygın zoo- notik bir hastalıktır. Hidatik kistlerin tanısı klinik, seroloji ve radyolojik bulgulara dayanır. Medikal ve cerrahi tedavi seçenekleri mevcuttur. Bu çalışmada pediyatrik hidatik kist olgularının klinik, epidemiyolojik özel- liklerini, laboratuvar ve radyografik bulgularını değerlendirmeyi amaç- ladık. Gereç ve Yöntemler: 2012-2022 yılları arasında hastanemizde takip edilen 84 pediyatrik kist hidatik olgusu çalışmaya dahil edildi. Olguların epidemiyolojik ve klinik özellikleri değerlendirildi. Bulgular: Seksen dört hastanın 50 (%59.5)’si erkekti ve yaş ortalaması 137 aydı. Hastaların 48 (%57.1)’i kırsal kesimdendi ve 38 (%45.2)’inin hay- van teması vardı. İndirekt hemaglütinasyon testi olguların %54.8’inde pozitifti ve %48.8’inde eozinofili vardı. Hastaların %41.7’sinde akciğer kisti, %32.1’inde karaciğer kisti, %23.8’inde akciğer ve karaciğer kisti saptandı. Hastaların %71.4’üne cerrahi ve albendazol tedavisi, %25’ine sadece medikal tedavi ve bir olguya PAIR uygulandı. Akciğer kisti olan hastalarda rüptür riski daha yüksek bulunurken, karaciğer kisti olan has- talarda İHA pozitifliği daha yüksekti. Sonuç: Hidatik kist tüm dünya için bir halk sağlığı sorunu olmaya de - vam etmektedir. Toplumun eğitimi, bulaşmayı ve yayılımı önleyici ted- birlerin alınması, kist hidatikten en önemli korunma yöntemidir. Stan- dart bir tedavi rejimi olmamakla birlikte cerrahi veya medikal tedavi kararında kistin boyutu, yeri ve sayısı önemlidir.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Casulli A. New global targets for NTDs in the WHO roadmap 2021-2030. PLoS Negl Trop Dis 2021;15(5):e0009373. https://doi.org/10.1371/journal.pntd.0009373
- 2. WHO. Echinococcosis. 2021. Available from: https://www.who.int/ en/news-room/fact-sheets/detail/echinococcosis (Accessed date: 01.09.2022).
- 3. Gürler AT, Bölükbaş CS, Açıcı M, Umur Ş. Overview of Echinococcus multilocularis in Turkey and in the World. Turkiye Parazitol Derg 2019;43(Suppl 1):18-35. https://doi.org/10.4274/tpd.galenos.2019.6300
- 4. Djuricic SM, Grebeldinger S, Kafka DI, Djan I, Vukadin M, Vasiljevic ZV. Cystic echinococcosis in children-the seventeen-year experience of two large medical centers in Serbia. Parasitol Int 2010;59(2):257-61. https:// doi.org/10.1016/j.parint.2010.02.011
- 5. Moro P, Schantz PM. Echinococcosis: A review. Int J Infect Dis 2009;13(2):125-33. https://doi.org/10.1016/j.ijid.2008.03.037
- 6. Brunetti E, Kern P, Vuitton DA, Writing panel for the W-I. Expert consensus for the diagnosis and treatment of cystic and alveolar echinococcosis in humans. Acta Trop 2010;114(1):1-16. https://doi.org/10.1016/j. actatropica.2009.11.001
- 7. Belard S, Tamarozzi F, Bustinduy AL, Wallrauch C, Grobusch MP, Kuhn W, et al. Point-of care ultrasound assessment of tropical infectious diseases-a review of applications and perspectives. Am J Trop Med Hyg 2016;94(1):8-21. https://doi.org/10.4269/ajtmh.15-0421
- 8. Akcam AT, Ulku A, Koltas IS, Izol V, Bicer OS, Kilicbagir E, et al. Clinical characterization of unusual cystic echinococcosis in southern part of Turkey. Ann Saudi Med 2014;34(6):508-16. https://doi. org/10.5144/0256-4947.2014.508
- 9. Lissandrin R, Tamarozzi F, Piccoli L, Tinelli C, De Silvestri A, Mariconti M, et al. Factors influencing the serological response in hepatic echinococcus granulosus infection. Am J Trop Med Hyg 2016;94(1):166-71. https://doi.org/10.4269/ajtmh.15-0219
- 10. Hijjawi NS, Al-Radaideh AM, Rababah EM, Al-Qaoud KM, Bani-Hani KE. Cystic echinococcosis in Jordan: A review of causative species, previous studies, serological and radiological diagnosis. Acta Trop 2018;179:10- 6. https://doi.org/10.1016/j.actatropica.2017.12.017
- 11. Gomez IGC, Lopez-Andujar R, Belda Ibanez T, Ramia Angel JM, Moya Herraiz A, Orbis Castellanos F, et al. Review of the treatment of liver hydatid cysts. World J Gastroenterol 2015;21(1):124-31. https://doi. org/10.3748/wjg.v21.i1.124
- 12. Manterola C, Otzen T. Surgical alternatives used in the treatment of liver hydatid cyst. A systematized approach based on evidence (an overview). Int J Morphol 2016;34:699-707. https://doi.org/10.4067/S0717- 95022016000200044
- 13. Tamarozzi F, Akhan O, Cretu CM, Vutova K, Akinci D, Chipeva R, et al. Prevalence of abdominal cystic echinococcosis in rural Bulgaria, Romania, and Turkey: A cross-sectional, ultrasound-based, population study from the HERACLES project. Lancet Infect Dis 2018;18(7):769-78. https://doi.org/10.1016/S1473-3099(18)30221-4
- 14. Jordanova DP, Harizanov RN, Kaftandjiev IT, Rainova IG, Kantardjiev TV. Cystic echinococcosis in Bulgaria 1996-2013, with emphasis on childhood infections. Eur J Clin Microbiol Infect Dis 2015;34(7):1423-8. https://doi.org/10.1007/s10096-015-2368-z
- 15. Tamarozzi F, Akhan O, Cretu CM, Vutova K, Fabiani M, Orsten S, et al. Epidemiological factors associated with human cystic echinococcosis: A semi-structured questionnaire from a large population-based ultrasound cross-sectional study in eastern Europe and Turkey. Parasit Vectors 2019;12(1):371. https://doi.org/10.1186/s13071-019-3634-1
- 16. Altintas NA, Altintas NU, Sarica Yilmaz O, Akil M, Akdur Ozturk E, Unver A. Educational intervention for the awareness improvement and control programme design on echinococcosis in Izmir, Turkey. Helminthologia 2021;58(2):152-61. https://doi.org/10.2478/helm-2021-0013
- 17. Tüz AE, Ekemen Keleş Y, Şahin A, Üstündağ G, Taşar S, Karadağ Öncel E, et al. Hydatid disease in children from diagnosis to treatment: A 10- year single center experience. Turkiye Parazitol Derg 2022;46(3):189-94. https://doi.org/10.4274/tpd.galenos.2022.69885
- 18. Tao J, Du X, Liu K, Wang C, Lv Y, Wang M, et al. Clinical characteristics and antibodies against Echinococcus granulosus recombinant antigen P29 in patients with cystic echinococcosis in China. BMC Infect Dis 2022;22(1):609. https://doi.org/10.1186/s12879-022-07597-8
- 19. Oral A, Yigiter M, Yildiz A, Yalcin O, Dikmen T, Eren S, et al. Diagnosis and management of hydatid liver disease in children: A report of 156 patients with hydatid disease. J Pediatr Surg 2012;47(3):528-34. https:// doi.org/10.1016/j.jpedsurg.2011.11.007
- 20. Koca T, Dereci S, Gencer A, Duman L, Aktaş AR. Çocukluk çağında kistik ekinokokkozis: Tek merkezin beş yıllık deneyimi. Turkiye Parazitol Derg 2016;40(1):26-31. https://doi.org/10.5152/tpd.2016.4381
- 21. Akcam AT, Ulku A, Koltas IS, Izol V, Bicer OS, Kilicbagir E, et al. Clinical characterization of unusual cystic echinococcosis in southern part of Turkey. Ann Saudi Med 2014;34(6):508-16. https://doi. org/10.5144/0256-4947.2014.508
- 22. Lissandrin R, Tamarozzi F, Piccoli L, Tinelli C, De Silvestri A, Mariconti M, et al. Factors influencing the serological response in hepatic echinococcus granulosus infection. Am J Trop Med Hyg 2016;94(1):166-71. https://doi.org/10.4269/ajtmh.15-0219
- 23. Tartar T, Bakal U, Sarac M, Kazez A. Laboratory results and clinical findings of children with hydatid cyst disease. Niger J Clin Pract 2020;23(7):1008-12. https://doi.org/10.4103/njcp.njcp_531_19
- 24. Köktürk O. Parazit hastalıkları grup baskısı. Toraks Derneği Akciğer Hastalıkları Tanı ve Tedavi Rehberi. Toraks Derg 3 (2002):161-7.
- 25. Petropoulos AS, Chatzoulis GA. Echinococcus granulosus in childhood: A retrospective study of 187 cases and newer data. Clin Pediatr (Phila) 2019;58:864-88. https://doi.org/10.1177/0009922819847032
- 26. Keser SH, Selek A, Ece D, Barişik CC, Şensu S, Geçmen GG, et al. Review of hydatid cyst with focus on cases with unusual locations. Turk Patoloji Derg 2017;33(1):30-6.
- 27. WHO Informal Working Group on Echinococcosis & World Health Organization. Dept. of Epidemic and Pandemic Alert and Response. 2001. Puncture, Aspiration, Injection, Re-aspiration: An option for the treatment of cystic echinococcosis/WHO Informal Working Group on Echinocossosis. 64 Geneva: World Health Organization. Available from: http://www.who.int/iris/ handle/10665/67207
- 28. Giorgio A, Calisti G, de Stefano G, Farella N, Scognamiglio U, Giorgio V. Percutaneous treatment of hydatid liver cysts: An update. Recent Pat Antiinfect Drug Discov 2012;7(3):231-6. https://doi. org/10.2174/157489112803521913
- 29. Sarkar M, Pathania R, Jhobta A, Thakur BR, Chopra R. Cystic pulmonary hydatidosis. Lung India 2016;33(2):179-91. https://doi. org/10.4103/0970-2113.177449
- 30. Keramidas D, Mavridis G, Soutis M, Passalidis A. Medical treatment of pulmonary hydatidosis: Complications and surgical management. Pediatr Surg Int 2004;19(12):774-6. https://doi.org/10.1007/s00383-003- 1031-4
- 31. Todorov T, Vutova K, Donev S, Ivanov A, Katzarov K, Takov D. The types and timing of the degenerative changes seen in the cysts during and after benzimidazole treatment of cystic echinococcosis. Ann Trop Med Parasitol 2005;99(7):649-59. https://doi.org/10.1179/136485905X65125
| APA | kara y, KIZIL M, İŞERİ NEPESOV M, Öztunalı Ç, Arda M, Ilhan H, Dogan N, Kilic O, Dinleyici E (2023). Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases. , 242 - 248. 10.5578/ced.20239603 |
| Chicago | kara yalçın,KIZIL MAHMUT CAN,İŞERİ NEPESOV MERVE,Öztunalı Çiğdem,Arda Mehmet Surhan,Ilhan Huseyin,Dogan Nihal,Kilic Omer,Dinleyici Ener Cagri Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases. (2023): 242 - 248. 10.5578/ced.20239603 |
| MLA | kara yalçın,KIZIL MAHMUT CAN,İŞERİ NEPESOV MERVE,Öztunalı Çiğdem,Arda Mehmet Surhan,Ilhan Huseyin,Dogan Nihal,Kilic Omer,Dinleyici Ener Cagri Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases. , 2023, ss.242 - 248. 10.5578/ced.20239603 |
| AMA | kara y,KIZIL M,İŞERİ NEPESOV M,Öztunalı Ç,Arda M,Ilhan H,Dogan N,Kilic O,Dinleyici E Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases. . 2023; 242 - 248. 10.5578/ced.20239603 |
| Vancouver | kara y,KIZIL M,İŞERİ NEPESOV M,Öztunalı Ç,Arda M,Ilhan H,Dogan N,Kilic O,Dinleyici E Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases. . 2023; 242 - 248. 10.5578/ced.20239603 |
| IEEE | kara y,KIZIL M,İŞERİ NEPESOV M,Öztunalı Ç,Arda M,Ilhan H,Dogan N,Kilic O,Dinleyici E "Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases." , ss.242 - 248, 2023. 10.5578/ced.20239603 |
| ISNAD | kara, yalçın vd. "Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases". (2023), 242-248. https://doi.org/10.5578/ced.20239603 |
| APA | kara y, KIZIL M, İŞERİ NEPESOV M, Öztunalı Ç, Arda M, Ilhan H, Dogan N, Kilic O, Dinleyici E (2023). Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases. Çocuk Enfeksiyon Dergisi, 17(4), 242 - 248. 10.5578/ced.20239603 |
| Chicago | kara yalçın,KIZIL MAHMUT CAN,İŞERİ NEPESOV MERVE,Öztunalı Çiğdem,Arda Mehmet Surhan,Ilhan Huseyin,Dogan Nihal,Kilic Omer,Dinleyici Ener Cagri Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases. Çocuk Enfeksiyon Dergisi 17, no.4 (2023): 242 - 248. 10.5578/ced.20239603 |
| MLA | kara yalçın,KIZIL MAHMUT CAN,İŞERİ NEPESOV MERVE,Öztunalı Çiğdem,Arda Mehmet Surhan,Ilhan Huseyin,Dogan Nihal,Kilic Omer,Dinleyici Ener Cagri Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases. Çocuk Enfeksiyon Dergisi, vol.17, no.4, 2023, ss.242 - 248. 10.5578/ced.20239603 |
| AMA | kara y,KIZIL M,İŞERİ NEPESOV M,Öztunalı Ç,Arda M,Ilhan H,Dogan N,Kilic O,Dinleyici E Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases. Çocuk Enfeksiyon Dergisi. 2023; 17(4): 242 - 248. 10.5578/ced.20239603 |
| Vancouver | kara y,KIZIL M,İŞERİ NEPESOV M,Öztunalı Ç,Arda M,Ilhan H,Dogan N,Kilic O,Dinleyici E Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases. Çocuk Enfeksiyon Dergisi. 2023; 17(4): 242 - 248. 10.5578/ced.20239603 |
| IEEE | kara y,KIZIL M,İŞERİ NEPESOV M,Öztunalı Ç,Arda M,Ilhan H,Dogan N,Kilic O,Dinleyici E "Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases." Çocuk Enfeksiyon Dergisi, 17, ss.242 - 248, 2023. 10.5578/ced.20239603 |
| ISNAD | kara, yalçın vd. "Evaluation of Clinical and Epidemiological Characteristics and Treatment Methods of Pediatric Hydatid Cyst Cases". Çocuk Enfeksiyon Dergisi 17/4 (2023), 242-248. https://doi.org/10.5578/ced.20239603 |
