The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels

ÇAKIR, Elif; KAYA, Mehmet G.; kalay, nihat; ALTUNKAŞ, Fatih; KOÇ, FATİH; AYTEKİN, Metin; SÖĞÜT, Erkan; ÖZBEK, Kerem; KARAYAKALI, METIN

The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels

Nihat KALAY, (Erciyes Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kayseri, Türkiye)

Metin AYTEKİN, (Department of Pathobiology, Cleveland Clinic Foundation, Cleveland, Ohio, USA)

Mehmet G. KAYA, (Erciyes Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Kayseri, Türkiye)

Kerem ÖZBEK, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tokat, Türkiye)

Metin KARAYAKALI, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tokat, Türkiye)

Erkan SÖĞÜT, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Biyokimya Anabilim Dalı, Tokat, Türkiye)

Fatih ALTUNKAŞ, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tokat, Türkiye)

Ahmet ÖZTÜRK, (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tokat, Türkiye)

Fatih KOÇ (Gaziosmanpaşa Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Tokat, Türkiye)

Türk Kardiyoloji Derneği Arşivi

2 2

Yıl: 2011 Cilt: 39 Sayı: 6 Sayfa Aralığı: 463 - 468 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels

Öz:

Objectives: The underlying mechanism of slow coronary flow (SCF) has yet to be elucidated. Increased red cell distribution width (RDW) and uric acid level may be indicative of an underlying inflammatory state. We aimed to investigate RDW and serum uric acid levels in patients with normal coronary arteries and SCF without stenosis. Study design: The study included 46 consecutive patients (25 males, 21 females; mean age 54±11 years) with angiographically normal coronary arteries but having SCF in all three coronary arteries. The control group consisted of 40 patients (18 males, 22 females; mean age 54±9 years) with angiographically normal coronary arteries without SCF. In both groups, RDW and serum uric acid levels were measured and compared. Results: In the SCF group, TIMI frame counts measured in the left anterior descending coronary artery, left circumflex coronary artery, and right coronary artery were significantly higher compared to the control group (p<0.05). Patients with SCF exhibited significantly higher RDW (13.4±1.6% vs. 12.6±1.2%, p=0.01) and serum uric acid levels (5.3±1.6 mg/dl vs. 4.7±1.3 mg/dl, p=0.01) compared to controls. In logistic regression analysis, uric acid [Exp(B)=1.612, 95% CI 0.206-5.35, p=0.021] and RDW [Exp(B)=1.496, 95% CI 0.403-4.72, p=0.030] were found as independent predictors of SCF. Conclusion: Our findings show that patients with SCF have significantly increased RDW and serum uric acid levels. This may help throw more light on the pathophysiological basis of SCF.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Enflamasyon ve yavaş koroner akım ilişkisi: Kırmızı kan hücrelerinin dağılım genişliğinde ve serum ürik asit düzeylerinde artış

Öz:

Amaç: Yavaş koroner akımın (YKA) nedenleri tam olarak anlaşılamamıştır. Kırmızı kan hücrelerinin dağılım genişliğinde (KHDG) artma ve yüksek ürik asit düzeyi enflamasyon için belirteç olabilir. Bu çalışmada, koroner anjiyografide koroner damarlarda daralma olmaksızın YKA bulunan hastalarda KHDG ve serum ürik asit düzeyleri araştırıldı. Çalışma planı: Çalışmaya, koroner anjiyografide koroner arterleri normal bulunmasına karşın, üç ana koroner arterde de YKA saptanan ardışık 46 hasta (25 erkek 21 kadın; ort. yaş 54±11) ile kontrol grubu olarak, koroner arterleri normal bulunan ve YKA olmayan 40 hasta (18 erkek, 22 kadın; ort. yaş 54±9) alındı. İki grupta KHDG ve serum ürik asit düzeyleri ölçülerek karşılaştırıldı. Bulgular: Yavaş koroner akım grubunda sol ön inen arter, sirkumfleks arter ve sağ koroner arterde ölçülen TIMI kare sayıları kontrol grubuna göre anlamlı yükseklik gösterdi (p<0.05). Ortalama KHDG ve serum ürik asit düzeyi YKA grubunda kontrol grubuna göre anlamlı derecede daha yüksek bulundu (sırasıyla, %13.4±1.6 ve %12.6±1.2, p=0.01; 5.3±1.6 mg/dl ve 4.7±1.3 mg/ dl, p=0.01). Lojistik regresyon analizinde, ürik asit [Exp(B)=1.612, %95 GA 0.206-5.35, p=0.021] ve KHDG [Exp(B)=1.496, %95 GA 0.403-4.72, p=0.030] YKA için bağımsız öngördürücüler idi. Sonuç: Bulgularımız YKA’lı hastalarda KHDG ve serum ürik asit düzeyinin anlamlı derecede yükseldiğini göstermiştir. Bu bulgu YKA’nın patofizyolojik temelini anlamamıza yardımcı olabilir.

Anahtar Kelime:

Konular: Kalp ve Kalp Damar Sistemi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	kalay n, AYTEKİN M, KAYA M, ÖZBEK K, KARAYAKALI M, SÖĞÜT E, ALTUNKAŞ F, ÇAKIR E, KOÇ F (2011). The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels. , 463 - 468.
Chicago	kalay nihat,AYTEKİN Metin,KAYA Mehmet G.,ÖZBEK Kerem,KARAYAKALI METIN,SÖĞÜT Erkan,ALTUNKAŞ Fatih,ÇAKIR Elif,KOÇ FATİH The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels. (2011): 463 - 468.
MLA	kalay nihat,AYTEKİN Metin,KAYA Mehmet G.,ÖZBEK Kerem,KARAYAKALI METIN,SÖĞÜT Erkan,ALTUNKAŞ Fatih,ÇAKIR Elif,KOÇ FATİH The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels. , 2011, ss.463 - 468.
AMA	kalay n,AYTEKİN M,KAYA M,ÖZBEK K,KARAYAKALI M,SÖĞÜT E,ALTUNKAŞ F,ÇAKIR E,KOÇ F The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels. . 2011; 463 - 468.
Vancouver	kalay n,AYTEKİN M,KAYA M,ÖZBEK K,KARAYAKALI M,SÖĞÜT E,ALTUNKAŞ F,ÇAKIR E,KOÇ F The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels. . 2011; 463 - 468.
IEEE	kalay n,AYTEKİN M,KAYA M,ÖZBEK K,KARAYAKALI M,SÖĞÜT E,ALTUNKAŞ F,ÇAKIR E,KOÇ F "The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels." , ss.463 - 468, 2011.
ISNAD	kalay, nihat vd. "The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels". (2011), 463-468.

APA	kalay n, AYTEKİN M, KAYA M, ÖZBEK K, KARAYAKALI M, SÖĞÜT E, ALTUNKAŞ F, ÇAKIR E, KOÇ F (2011). The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels. Türk Kardiyoloji Derneği Arşivi, 39(6), 463 - 468.
Chicago	kalay nihat,AYTEKİN Metin,KAYA Mehmet G.,ÖZBEK Kerem,KARAYAKALI METIN,SÖĞÜT Erkan,ALTUNKAŞ Fatih,ÇAKIR Elif,KOÇ FATİH The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels. Türk Kardiyoloji Derneği Arşivi 39, no.6 (2011): 463 - 468.
MLA	kalay nihat,AYTEKİN Metin,KAYA Mehmet G.,ÖZBEK Kerem,KARAYAKALI METIN,SÖĞÜT Erkan,ALTUNKAŞ Fatih,ÇAKIR Elif,KOÇ FATİH The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels. Türk Kardiyoloji Derneği Arşivi, vol.39, no.6, 2011, ss.463 - 468.
AMA	kalay n,AYTEKİN M,KAYA M,ÖZBEK K,KARAYAKALI M,SÖĞÜT E,ALTUNKAŞ F,ÇAKIR E,KOÇ F The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels. Türk Kardiyoloji Derneği Arşivi. 2011; 39(6): 463 - 468.
Vancouver	kalay n,AYTEKİN M,KAYA M,ÖZBEK K,KARAYAKALI M,SÖĞÜT E,ALTUNKAŞ F,ÇAKIR E,KOÇ F The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels. Türk Kardiyoloji Derneği Arşivi. 2011; 39(6): 463 - 468.
IEEE	kalay n,AYTEKİN M,KAYA M,ÖZBEK K,KARAYAKALI M,SÖĞÜT E,ALTUNKAŞ F,ÇAKIR E,KOÇ F "The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels." Türk Kardiyoloji Derneği Arşivi, 39, ss.463 - 468, 2011.
ISNAD	kalay, nihat vd. "The relationship between inflammation and slow coronary flow: Increased red cell distribution width and serum uric acid levels". Türk Kardiyoloji Derneği Arşivi 39/6 (2011), 463-468.