Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]
Yıl: 2016 Cilt: 22 Sayı: 6 Sayfa Aralığı: 837 - 846 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022
Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]
Öz: Uterusun bakteriyel invazyonu sonucu irin toplanmasıyla karakterize olan pyometra sıklıkla sistemik bir enflamasyonu başlatabilir ve bu da hastayı çoklu organ yetmezliğine sürükleyebilir (MODS). Çalışmanın amaçlarından biri, pyometralı ve sağlıklı köpeklerde kanda C-reaktif protein (CRP), tümör nekrozis faktör-? (TNF-?), interlökin-6 (IL-6), süperoksit dizmutaz (SOD), katalaz (CAT) ve tiyobarbitürik asit reaktif ürünleri (TBARS) gibi parametrelere bakılarak gruplar arasındaki varyasyon tespitiyle morbidite tahmininin yapılması ve bu parametrelerle MODS arasındaki ilişkinin ortaya çıkarılmasıdır. Çalışmaya dahil edilen köpeklerden kan alınarak ovariohisterektomi operasyonu uygulandı, on beş gün sonra ikinci kez kan alınarak aynı parametreler tekrar değerlendirildi ve bu süreçte grup içi ve gruplar arasındaki değişime bakıldı. TNF-?, CRP ve IL-6 düzeyleri operasyon öncesi pyometralı grupta önemli oranda yüksek bulundu (sırasıyla, P<0.05, P<0.001, P<0.001), Ovariohisterektomi sonrasında 15. gün yapılan kan değerlendirmelerinde ise CRP ve IL-6'nın pyometralı grupta hala yüksek olduğu görüldü (sırasıyla, P<0.001, P<0.05). Çift segmentli nötrofillerin sayısı pyometralı köpeklerde operasyon öncesi ve sonrası gruplara ve zamana bağlı olarak önemli düzeyde düşük olduğu tespit edildi (P<0.01). Bu çalışmayla CRP ve IL-6 değerlerinin pyometralı köpeklerde ovariohisterektomi sonrası enflamasyonun devam edip etmediğinin bir göstergesi olarak kullanılabileceği sonucuna varıldı. Yine trombosit (PLT) düzeyi ve nötrofil segmentasyon indekslerinin (NSI) pyometranın kronik yapısının ve şiddetinin belirlenmesinde iyi birer gösterge olduğu kanaatine varılmıştır. Aynı zamanda, pyometralı köpeklerin kanamayı arttıran dissemine intravasküler koagülasyon (DIC) riski altında olabileceğinin ortaya konulduğu düşünülmektedir.
Anahtar Kelime: Konular:
Köpeklerde Pyometranın Bazı Oksidatif Stres Parametreleri, İnflamatorik Mediyatörler ve Nötrofil Segmentasyonu Üzerine Etkileri
Öz: Pyometra is characterized by uterine bacterial infection with the accumulation of pus in the uterus often initiates systemic inflammation in the body and may lead to multiple organ dysfunction syndrome (MODS). The main objectives of this study is to evaluate C-reactive protein (CRP), tumour necrosis factor-? (TNF-?), interleukin-6 (IL-6), superoxide dismutase (SOD), catalase (CAT), and thiobarbituric acid-reactive substances (TBARS) in bitches with pyometra and control bitches to explore the possible variety between the groups to detect the morbidity of the disease and contribution of these parameters in the condition of MODS. All bitches underwent ovariohysterectomy (OVH) and blood sampling was performed just before and after 15 days of the surgery. TNF-?, CRP, and IL-6 levels were significantly higher in pyometra group before the OVH (P<0.05, P<0.001, P<0.001, respectively), and CRP and IL-6 levels were significantly high after 15 days of OVH (P<0.001, P<0.05, respectively). Two-segmented neutrophils were significantly lower in pyometra group before (P<0.05) and after OVH (P<0.01). It is revealed that with this study, CRP and IL-6 could be used for inflammation detection when leucocyte number was normal in operated bitches with pyometra. Oxidative stress was not apparent in bitches with pyometra. Also, platelet (PLT) level and neutrophil segmentation index (NSI) might be good indicators to identify the chronic phase and the severity of the disease and risk of disseminated intravascular coagulation (DIC) in bitches with pyometra.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | TOYDEMİR KARABULUT T, İNAL GÜLTEKİN G, Ates A, YILMAZ TURNA Ö, ENGINLER S, KIRŞAN İ, ERDOĞAN BAMAÇ Ö, ARUN S, Demirtas B (2016). Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]. , 837 - 846. |
| Chicago | TOYDEMİR KARABULUT Tuğba Seval Fatma,İNAL GÜLTEKİN GÜLDAL,Ates Atila,YILMAZ TURNA Özge,ENGINLER SINEM OZLEM,KIRŞAN İSMAİL,ERDOĞAN BAMAÇ Özge,ARUN Seçkin Serdar,Demirtas Berjan Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]. (2016): 837 - 846. |
| MLA | TOYDEMİR KARABULUT Tuğba Seval Fatma,İNAL GÜLTEKİN GÜLDAL,Ates Atila,YILMAZ TURNA Özge,ENGINLER SINEM OZLEM,KIRŞAN İSMAİL,ERDOĞAN BAMAÇ Özge,ARUN Seçkin Serdar,Demirtas Berjan Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]. , 2016, ss.837 - 846. |
| AMA | TOYDEMİR KARABULUT T,İNAL GÜLTEKİN G,Ates A,YILMAZ TURNA Ö,ENGINLER S,KIRŞAN İ,ERDOĞAN BAMAÇ Ö,ARUN S,Demirtas B Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]. . 2016; 837 - 846. |
| Vancouver | TOYDEMİR KARABULUT T,İNAL GÜLTEKİN G,Ates A,YILMAZ TURNA Ö,ENGINLER S,KIRŞAN İ,ERDOĞAN BAMAÇ Ö,ARUN S,Demirtas B Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]. . 2016; 837 - 846. |
| IEEE | TOYDEMİR KARABULUT T,İNAL GÜLTEKİN G,Ates A,YILMAZ TURNA Ö,ENGINLER S,KIRŞAN İ,ERDOĞAN BAMAÇ Ö,ARUN S,Demirtas B "Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]." , ss.837 - 846, 2016. |
| ISNAD | TOYDEMİR KARABULUT, Tuğba Seval Fatma vd. "Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]". (2016), 837-846. |
| APA | TOYDEMİR KARABULUT T, İNAL GÜLTEKİN G, Ates A, YILMAZ TURNA Ö, ENGINLER S, KIRŞAN İ, ERDOĞAN BAMAÇ Ö, ARUN S, Demirtas B (2016). Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 22(6), 837 - 846. |
| Chicago | TOYDEMİR KARABULUT Tuğba Seval Fatma,İNAL GÜLTEKİN GÜLDAL,Ates Atila,YILMAZ TURNA Özge,ENGINLER SINEM OZLEM,KIRŞAN İSMAİL,ERDOĞAN BAMAÇ Özge,ARUN Seçkin Serdar,Demirtas Berjan Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]. Kafkas Üniversitesi Veteriner Fakültesi Dergisi 22, no.6 (2016): 837 - 846. |
| MLA | TOYDEMİR KARABULUT Tuğba Seval Fatma,İNAL GÜLTEKİN GÜLDAL,Ates Atila,YILMAZ TURNA Özge,ENGINLER SINEM OZLEM,KIRŞAN İSMAİL,ERDOĞAN BAMAÇ Özge,ARUN Seçkin Serdar,Demirtas Berjan Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]. Kafkas Üniversitesi Veteriner Fakültesi Dergisi, vol.22, no.6, 2016, ss.837 - 846. |
| AMA | TOYDEMİR KARABULUT T,İNAL GÜLTEKİN G,Ates A,YILMAZ TURNA Ö,ENGINLER S,KIRŞAN İ,ERDOĞAN BAMAÇ Ö,ARUN S,Demirtas B Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2016; 22(6): 837 - 846. |
| Vancouver | TOYDEMİR KARABULUT T,İNAL GÜLTEKİN G,Ates A,YILMAZ TURNA Ö,ENGINLER S,KIRŞAN İ,ERDOĞAN BAMAÇ Ö,ARUN S,Demirtas B Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]. Kafkas Üniversitesi Veteriner Fakültesi Dergisi. 2016; 22(6): 837 - 846. |
| IEEE | TOYDEMİR KARABULUT T,İNAL GÜLTEKİN G,Ates A,YILMAZ TURNA Ö,ENGINLER S,KIRŞAN İ,ERDOĞAN BAMAÇ Ö,ARUN S,Demirtas B "Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]." Kafkas Üniversitesi Veteriner Fakültesi Dergisi, 22, ss.837 - 846, 2016. |
| ISNAD | TOYDEMİR KARABULUT, Tuğba Seval Fatma vd. "Effects of Pyometra on Some Oxidative Stress Parameters, Inflammatory Mediators and Neutrophil Segmentation in Bitches [1]". Kafkas Üniversitesi Veteriner Fakültesi Dergisi 22/6 (2016), 837-846. |
