Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri

Nalbantsoy, Ayse; Baykan, Sura; ALBAYRAK, Gökay

Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri

Gökay ALBAYRAK, (Ege University, Faculty of Pharmacy, Department of Pharmaceutical Botany, İzmir, Turkey)

Ayşe NALBANTSOY, (Ege University, Faculty of Engineering, Department of Bioengineering, İzmir, Turkey)

Şüra BAYKAN (Ege University, Faculty of Pharmacy, Department of Pharmaceutical Botany, İzmir, Turkey)

Turkish Journal of Pharmaceutical Sciences

14 1

Yıl: 2017 Cilt: 14 Sayı: 3 Sayfa Aralığı: 231 - 236 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri

Öz:

The objective of this study was to examine the anti-inflammatory and cytotoxic potential of n-hexane, ethyl acetate, and methanolicextracts of Tanacetum argenteum subsp. argenteum.Materials and Methods: Tanacetum L. is the third largest genus of Asteraceae family and is represented by 60 taxa in Turkish flora. Sesquiterpenelactones and pyrethrins are the main chemical groups of the genus. T. argenteum subsp. argenteum is an endemic taxa that is distributed in theCentral and South Anatolia.Results: In vitro anti-inflammatory activity was assayed using iNOS and NF-?B inhibition tests on RAW264.7 and HeLa cells. The cytotoxic activitieswere tested against ten cell lines using MTT assays.Conclusion: As a result, the n-hexane extract was found more active than the positive control parthenolide in iNOS test (IC50: 0.627±0.16 ?g/mL) andcytotoxic experiments against PC3 and MPANC-96 cell lines (IC50: 2.85±0.51 ?g/mL and 5.35±1.24 ?g/mL, respectively).

Anahtar Kelime:

Konular: Farmakoloji ve Eczacılık

In Vitro Cytotoxic and Anti-inflammatory Activities of Tanacetum argenteum (Lam.) Willd. subsp. argenteum Extract

Öz:

Objectives: The objective of this study was to examine the anti-inflammatory and cytotoxic potential of n-hexane, ethyl acetate, and methanolic extracts of Tanacetum argenteum subsp. argenteum. Materials and Methods: Tanacetum L. is the third largest genus of Asteraceae family and is represented by 60 taxa in Turkish flora. Sesquiterpene lactones and pyrethrins are the main chemical groups of the genus. T. argenteum subsp. argenteum is an endemic taxa that is distributed in the Central and South Anatolia.Results: In vitro anti-inflammatory activity was assayed using iNOS and NF-?B inhibition tests on RAW264.7 and HeLa cells. The cytotoxic activities were tested against ten cell lines using MTT assays. Conclusion: As a result, the n-hexane extract was found more active than the positive control parthenolide in iNOS test (IC50: 0.627±0.16 µg/mL) and cytotoxic experiments against PC3 and MPANC-96 cell lines (IC: 2.85±0.51 µg/mL and 5.35±1.24 µg/mL, respectively).

Anahtar Kelime:

Konular: Farmakoloji ve Eczacılık

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ALBAYRAK G, Nalbantsoy A, Baykan S (2017). Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri. , 231 - 236.
Chicago	ALBAYRAK Gökay,Nalbantsoy Ayse,Baykan Sura Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri. (2017): 231 - 236.
MLA	ALBAYRAK Gökay,Nalbantsoy Ayse,Baykan Sura Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri. , 2017, ss.231 - 236.
AMA	ALBAYRAK G,Nalbantsoy A,Baykan S Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri. . 2017; 231 - 236.
Vancouver	ALBAYRAK G,Nalbantsoy A,Baykan S Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri. . 2017; 231 - 236.
IEEE	ALBAYRAK G,Nalbantsoy A,Baykan S "Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri." , ss.231 - 236, 2017.
ISNAD	ALBAYRAK, Gökay vd. "Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri". (2017), 231-236.

APA	ALBAYRAK G, Nalbantsoy A, Baykan S (2017). Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri. Turkish Journal of Pharmaceutical Sciences, 14(3), 231 - 236.
Chicago	ALBAYRAK Gökay,Nalbantsoy Ayse,Baykan Sura Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri. Turkish Journal of Pharmaceutical Sciences 14, no.3 (2017): 231 - 236.
MLA	ALBAYRAK Gökay,Nalbantsoy Ayse,Baykan Sura Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri. Turkish Journal of Pharmaceutical Sciences, vol.14, no.3, 2017, ss.231 - 236.
AMA	ALBAYRAK G,Nalbantsoy A,Baykan S Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri. Turkish Journal of Pharmaceutical Sciences. 2017; 14(3): 231 - 236.
Vancouver	ALBAYRAK G,Nalbantsoy A,Baykan S Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri. Turkish Journal of Pharmaceutical Sciences. 2017; 14(3): 231 - 236.
IEEE	ALBAYRAK G,Nalbantsoy A,Baykan S "Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri." Turkish Journal of Pharmaceutical Sciences, 14, ss.231 - 236, 2017.
ISNAD	ALBAYRAK, Gökay vd. "Tanacetum argenteum subsp. argenteum Ekstrelerinin In Vitro Sitotoksik ve Anti-inflamatuvar Etkileri". Turkish Journal of Pharmaceutical Sciences 14/3 (2017), 231-236.