In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme

ÇOMAKLI, Veysel; KUZU, Müslüm; Şahin, Zafer; DEMİRDAĞ, Ramazan; Özkaya, Ahmet; DAĞ, Üzeyir

In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme

Müslüm KUZU, (Ağrı İbrahim Çeçen University, Faculty of Pharmacy, Ağrı, Turkey)

Ahmet ÖZKAYA, (Adıyaman University, Faculty of Arts and Sciences, Department of Chemistry, Adıyaman, Turkey)

Zafer ŞAHİN, (Necmettin Erbakan University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation, Konya, Turkey)

Üzeyir DAĞ, (Adıyaman University, Faculty of Arts and Sciences, Department of Chemistry, Adıyaman, Turkey)

Veysel ÇOMAKLI, (Ağrı İbrahim Çeçen University, School of Health, Department of Nutrition and Dietetics, Ağrı, Turkey)

Ramazan DEMİRDAĞ (Ağrı İbrahim Çeçen University, School of Health, Department of Nutrition and Dietetics, Ağrı, Turkey)

Turkish Journal of Pharmaceutical Sciences

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Yıl: 2017 Cilt: 14 Sayı: 1 Sayfa Aralığı: 9 - 12 Metin Dili: Türkçe İndeks Tarihi: 29-07-2022

In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme

Öz:

Amaç: Karbonik anhidraz (CA) enzimi CO2'nin su ile tersinir reaksiyonunu katalizler ve sistemik asit baz dengesi, solunum gibi metabolik açıdan oldukça önemli olaylarda görev alır. Bu çalışmada canlıların farklı yollarla maruz kaldığı bir ağır metal olan kurşun ile bir flavanon olan naringeninin enzim üzerine in vivo etkisi araştırıldı.Gereç ve Yöntemler: Bu amaçla, dört farklı sıçan grubu oluşturuldu ve bunlardan biri kontrol grubu olarak belirlendi. Diğer üç gruba ise kurşun, naringenin ve kurşun+naringenin maddeleri verildi ve eritrositlerdeki CA enzim aktivitesindeki değişimler incelendi. Bulgular: Araştırma bulguları kontrol grubundaki enzim aktivitesinin diğer gruplardan daha fazla olduğunu gösterdi. Kurşun grubu en düşük inhibisyon etkisini gösterirken, narigenin grubu en yüksek inhibisyon etkisini gösterdi.Sonuç: Bu nedenle naringeninin CA enzimi için kuvvetli bir inhibitör olduğu söylenebilir.

Anahtar Kelime:

Konular: Farmakoloji ve Eczacılık

Naringenin ve Kurşunun Sıçan Eritrosit Karbonik Anhidraz Enzimi Üzerine In Vivo Etkileri

Öz:

Objectives: Carbonic anhydrase (CA) enzyme catalyses the reversible reactions of CO2with water and takes part in metabolically important eventssuch as systemic acid-base regulation and respiration. In this study, in vivo effects of lead, which is a heavy metal and to which living beings areexposed by different ways, with naringenin, a flavanone, were investigated.Materials and Methods: For this purpose, four different rat groups were established and one of them was chosen as the control group. The otherthree groups were given lead, naringenin and lead+naringenin substances to analyze the changes in the CA enzyme of rat erythrocytes.Results:The research findings showed that the enzyme activity in the control group was higher than that in the other groups. The naringenin groupshowed the highest inhibition effect, while the lead group showed the lowest inhibition.Conclusion:Therefore, it can be said that naringenin is a strong inhibitor of the CA enzyme.

Anahtar Kelime:

Konular: Farmakoloji ve Eczacılık

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	KUZU M, Özkaya A, Şahin Z, DAĞ Ü, ÇOMAKLI V, DEMİRDAĞ R (2017). In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme. , 9 - 12.
Chicago	KUZU Müslüm,Özkaya Ahmet,Şahin Zafer,DAĞ Üzeyir,ÇOMAKLI Veysel,DEMİRDAĞ Ramazan In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme. (2017): 9 - 12.
MLA	KUZU Müslüm,Özkaya Ahmet,Şahin Zafer,DAĞ Üzeyir,ÇOMAKLI Veysel,DEMİRDAĞ Ramazan In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme. , 2017, ss.9 - 12.
AMA	KUZU M,Özkaya A,Şahin Z,DAĞ Ü,ÇOMAKLI V,DEMİRDAĞ R In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme. . 2017; 9 - 12.
Vancouver	KUZU M,Özkaya A,Şahin Z,DAĞ Ü,ÇOMAKLI V,DEMİRDAĞ R In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme. . 2017; 9 - 12.
IEEE	KUZU M,Özkaya A,Şahin Z,DAĞ Ü,ÇOMAKLI V,DEMİRDAĞ R "In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme." , ss.9 - 12, 2017.
ISNAD	KUZU, Müslüm vd. "In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme". (2017), 9-12.

APA	KUZU M, Özkaya A, Şahin Z, DAĞ Ü, ÇOMAKLI V, DEMİRDAĞ R (2017). In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme. Turkish Journal of Pharmaceutical Sciences, 14(1), 9 - 12.
Chicago	KUZU Müslüm,Özkaya Ahmet,Şahin Zafer,DAĞ Üzeyir,ÇOMAKLI Veysel,DEMİRDAĞ Ramazan In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme. Turkish Journal of Pharmaceutical Sciences 14, no.1 (2017): 9 - 12.
MLA	KUZU Müslüm,Özkaya Ahmet,Şahin Zafer,DAĞ Üzeyir,ÇOMAKLI Veysel,DEMİRDAĞ Ramazan In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme. Turkish Journal of Pharmaceutical Sciences, vol.14, no.1, 2017, ss.9 - 12.
AMA	KUZU M,Özkaya A,Şahin Z,DAĞ Ü,ÇOMAKLI V,DEMİRDAĞ R In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme. Turkish Journal of Pharmaceutical Sciences. 2017; 14(1): 9 - 12.
Vancouver	KUZU M,Özkaya A,Şahin Z,DAĞ Ü,ÇOMAKLI V,DEMİRDAĞ R In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme. Turkish Journal of Pharmaceutical Sciences. 2017; 14(1): 9 - 12.
IEEE	KUZU M,Özkaya A,Şahin Z,DAĞ Ü,ÇOMAKLI V,DEMİRDAĞ R "In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme." Turkish Journal of Pharmaceutical Sciences, 14, ss.9 - 12, 2017.
ISNAD	KUZU, Müslüm vd. "In Vivo Effects of Naringenin and Lead on Rat Erythrocyte Carbonic Anhydrase Enzyme". Turkish Journal of Pharmaceutical Sciences 14/1 (2017), 9-12.