Aim: This descriptive study is aimed to determine the stress causing factors of the students studying at nursing department and their coping methods. Method: The universe of the study consists of 531 students who have been studying at the Nursing Department of Mersin University School of Health and the sample consists of 280 students who accepted to participate in the study. ''Knowledge Form is related to stressfull situations in Nursing Students'' and ''Stress-Coping Style Scale'' were used for data collecting. In data analysis, percentage mean, median, 25-75% percentile, Mann Whitney U and Kruskal-Wallis variants analysis test were used. Results: The mean age of the students participated to the study was 21,0±2,0 years and 58,3% were 20 years and over. It was found out that the stress factors experienced by the students at clinical areas are as the followings 50,7% lecturers' attitude/compression behavior on nursing care plan, 63,2% patients' being the sense of insecurity against nursing students, 43,6% fear of making mistakes in clinical practice, %44,6 exam anxiety. It was also determined that 26,8% of the student nurses experience stress because of the lack of social activities and 22,5% of them experience because of the negative prejudice of nursing students' relatives towards nursing. It was determined that among the ways of coping with stress, the student nurses use the Self-Confidence Approach and Social Support Search method the most. Conclusion: In this study, it was determined that the student nurses were experiencing stress in the educational process, in the clinical setting and negative prejudice of the students' relatives towards nursing. Student nurses recognize these stressors and nurse academicians must have responsibilities to be able to cope with stress.