Background and Objective: Smoking addiction is among the most important public health problems worldwide. Physicianshave great responsibility for fighting with smoking due to both taking an active role in treatment and being a role model forthe community. The aim of the present study was to investigate the prevalence of using tobacco and tobacco products, andthe influencing factors in medical faculty students. Methods: This cross-sectional analytical study was conducted with 993medical students in 2017-2018 academic year. Results: Of the 993 students included in the study, 41.1% were male (n=408)and 58.9% (n=585) were female. While the frequency of smoking was 12.3%, ratio of the students who tried to smoke butdid not continue was 26.5%, ratio of non-smokers was 58.4% and ratio of the students who quit was 2.8%. In the study,22.5% of male students and 5.1% of female students were found to be smokers. Smoking rate was the highest in the 6th gradestudents with a ratio of 19.4%. A significant relationship was found between smoking status and being a higher gradestudent, the environment, the close friends, the fathers’ and siblings’ being smokers (p<0.05). The main factors for startingsmoking was found to be the effect of the close environment (42.6%) followed by stress (24.6%). Conclusion: The presentstudy has revealed that smoking prevalence and smoking dependence increased in 6th grade medical faculty students. Stressand the environment are the most important influencing factors. Education level of medical faculty students about smokingcessation and the harmful effects of smoking should be improved and they should be aware of their responsibility aboutsmoking cessation.