Objective: This cross-sectional, descriptive study evaluatedthe relationship between the caregiver burden and the psychosocial adjustment of caregivers to cardiac failure patients.Methods: Between November 18, 2015 and March 1, 2016,a preliminary information form, the Caregiver Burden Scale,and the Psychosocial Adjustment to Illness Scale were usedto assess the caregivers of 200 patients being treated in thecardiology service of a university hospital.Results: Among the caregivers, 75% were primary or secondary school graduates, 36% were housewives, and 43%were the patients’ spouse. Of the group, 71% had been caringfor the patients for 5 years or less. The caregivers describedcardiac failure as “difficulty with inhalation, fatigue, asthenia,insomnia, and swelling in the hands and feet.” They reportedfeelings of sorrow, fear, despair, bewilderment, anger, andguilt when they learned about the diagnosis, and they indicated that they generally managed those feelings by themselves. A total of 94% of the caregivers remarked that after thediagnosis they experienced physical, psychological, social,occupational, or economic changes. Of the respondents,74%felt sad and adversely affected, 71.5% faced difficulties withcare provision, and 84% felt anxiety about the possibility oflosing the patient while under their care, the disease prognosis, surgery (pacemaker implantation), and adjustment tothe treatment. The study participants’ caregiver burden andpsychosocial adjustment scale scores were below average.There were moderate statistically significant relationshipsbetween 3 subdimensions of the caregiver burden and psychosocial adjustment to illness scales (p<0.05).Conclusion: The participating caregivers of cardiac failurepatients described moderate difficulties due to caregiving andadjusting to the illness. It was determined that as the distressfelt due to caregiving increased, psychosocial adjustment toillness deteriorated.