PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE

ÖZEK, Gülmira

doi:10.18038/aubtda.392366

PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE

Gülmira ÖZEK (Anadolu Üniversitesi, Eczacılık Fakültesi, Farmakognozi Anabilim Dalı, Eskişehir, Türkiye)

Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering

6 1

Yıl: 2018 Cilt: 19 Sayı: 3 Sayfa Aralığı: 671 - 684 Metin Dili: İngilizce DOI: 10.18038/aubtda.392366 İndeks Tarihi: 28-09-2020

PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE

Öz:

The essential oil of Achillea grandifolia Friv. was obtained by hydrodistillation of aerial parts of the plant and analyzed withGC-FID and GC/MS techniques. The oil comprised mostly by the oxygenated monoterpenes (76.2 %) with $alpha$-terpinyl acetate(54.1 %) as main constituent. The monoterpene hydrocarbons were the second major compound group with p-cymene (17.7%) as the main representative. The essential oil showed free radical scavenging activity against DPPH•radicals (Inh. 52 %) andABTS+• cation radicals (TEAC 0.62 mM). The oil demonstrated hypoglycemic activity via inhibition of $alpha$ amylase (${IC}_{50}$ 0.15mg/mL). The effect of the oil on neurodegenerative disease was expressed via inhibition of acetylcholinesterase (AChE) andfound to be > 82 % of inhibition (an ${IC}_{50}$ of 1.77 mg/mL).

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ÖZEK G (2018). PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE. , 671 - 684. 10.18038/aubtda.392366
Chicago	ÖZEK Gülmira PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE. (2018): 671 - 684. 10.18038/aubtda.392366
MLA	ÖZEK Gülmira PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE. , 2018, ss.671 - 684. 10.18038/aubtda.392366
AMA	ÖZEK G PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE. . 2018; 671 - 684. 10.18038/aubtda.392366
Vancouver	ÖZEK G PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE. . 2018; 671 - 684. 10.18038/aubtda.392366
IEEE	ÖZEK G "PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE." , ss.671 - 684, 2018. 10.18038/aubtda.392366
ISNAD	ÖZEK, Gülmira. "PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE". (2018), 671-684. https://doi.org/10.18038/aubtda.392366

APA	ÖZEK G (2018). PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE. Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering, 19(3), 671 - 684. 10.18038/aubtda.392366
Chicago	ÖZEK Gülmira PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE. Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering 19, no.3 (2018): 671 - 684. 10.18038/aubtda.392366
MLA	ÖZEK Gülmira PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE. Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering, vol.19, no.3, 2018, ss.671 - 684. 10.18038/aubtda.392366
AMA	ÖZEK G PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE. Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering. 2018; 19(3): 671 - 684. 10.18038/aubtda.392366
Vancouver	ÖZEK G PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE. Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering. 2018; 19(3): 671 - 684. 10.18038/aubtda.392366
IEEE	ÖZEK G "PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE." Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering, 19, ss.671 - 684, 2018. 10.18038/aubtda.392366
ISNAD	ÖZEK, Gülmira. "PHYTOCHEMICAL CHARACTERIZATION OF ACHILLEA GRANDIFOLIA FRIV. ESSENTIAL OIL AND ITS POTENT AGAINST OXIDATIVE DAMAGE, ACETYLCHOLINESTERASE AND $alpha$ -AMYLASE". Eskişehir Technical University Journal of Science and and Technology A- Applied Sciences and Engineering 19/3 (2018), 671-684. https://doi.org/10.18038/aubtda.392366