Objective: The objective of this study was to evaluate the relationship of psychological disorders such as anxiety and depression with presence of coronary artery disease (CAD) among patients referred to coronary angiography (CAG) laboratory. Material and Methods: One hundred sixty three patients undergone CAG were consecutively included in the study. Sociodemographic features, cardiovascular risk factors, clinical features and current medications were recorded for all patients. The levels of anxiety and depression were examined according to Hospitalized Anxiety and Depression (HAD) measurements following coronary angiography (CAG). According to CAG results, the subjects were grouped to classify the severity of CAD as follows: percutaneous coronary intervention (PCI), coronary bypass grefting (CABG), non-critical coronary lesions, normal coronary arteries. Sociodemographic features, clinical features, severity of coronary artery disease were compared with HAD measurements accordingly. Results: The study included 62 female patients (38%). 62 patients were undergone for PCI, 30 patients were referred to CABG while 55 patients had non-significant CAD; 12 patients has normal coronary arteries (including slow flow). Among sociodemographic factors, only female patients, patient with low income or insomnia had significantly higher HAD values compared to male, high income or without insomnia respectively. In multivariate regression analysis including sociodemographic features, cardiovascular risk factors, clinical features and CAG results, only presence of insomnia (β=-0.243; p<0.05) and CAG results (β=0.202; p<0.05) was found to be significant independent variables related to anxiety while only age was found significant for depression. Conclusions: The study found that CAD can be related to anxiety level of patients.