This study was carried out in Early Sweet and Trakya Ilkeren grape varieties to determine the effects of 3 different solid growing medium Perlite: Peat (2: 1), Cocopeat and Pumice (Basaltic Pumice) and 2 different modified Hoagland nutrient solutions (A and B) on vegetative growth as well as the nutrient element content and chlorophyll levels of the leaves and grape yield and quality characteristics. It was determined that different media and nutrient solution application had no significant effect on stem diameters measured at different phenological stages in both varieties. In terms of SPAD values measured at the time of maturity of grapes, the difference between growing media was important but the difference between nutrient solutions was insignificant. The highest SPAD values were measured in Pumice (47.37) and Perlite:Peat (46.32) media in the same statistical group for Early Sweet and in the Pumice (43.62) for Trakya Ilkeren variety. The highest yield and cluster weight were obtained from Pumice (2066 g vine-1 and 344.4 g, respectively) for Early Sweet variety; from Perlite:Peat (1981 g vine-1 and 495.1 g respectively) for Trakya Ilkeren. In both varieties, yield and cluster weight were higher in B nutrient solution application. Nitrogen (N), phosphorus (P), potassium (K) and magnesium (Mg) concentrations in Trakya Ilkeren leaf samples were different according to the media and nutrient solution. In all applications; calcium (Ca) insufficient; zinc (Zn), manganese (Mn) and copper (Cu) were sufficient, while in Early Sweet N, P, Mg and iron (Fe) excess; K and Ca insufficient; Zn, Mn and Cu were found to be sufficient. As a result, it was determined that the suitable medium for table grape growing in soilless culture could vary according to the varieties, and that the use of B nutrient solution (containing a high amount of macro elements and a lower level of micro elements) increased yield and quality.