Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin

Ahmet Gökhan AĞGÜL, (Ağrı İbrahim Çecen Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Anabilim Dalı, Ağrı, Türkiye)
Müslüm KUZU, (Karabük Üniversitesi, Sağlık Bilimleri Fakültesi, Beslenme ve Diyetetik Bölümü, Karabük, Türkiye)
Fatih Mehmet Kandemir, (Atatürk Üniversitesi, Veteriner Fakültesi, Temel Bilimler Anabilim Dalı, Erzurum, Türkiye)
SEFA KÜÇÜKLER, (Atatürk Üniversitesi, Veteriner Fakültesi, Temel Bilimler Anabilim Dalı, Erzurum, Türkiye)
Cüneyt ÇAĞLAYAN (Bingöl Üniversitesi, Veteriner Fakültesi, Temel Bilimler Anabilim Dalı, Bingöl, Türkiye)
Clinical and Experimental Health Sciences
1 0
Yıl: 2020 Cilt: 10 Sayı: 3 Sayfa Aralığı: 228 - 234 Metin Dili: İngilizce DOI: 10.33808/clinexphealthsci.632320 İndeks Tarihi: 20-12-2021

Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin

Öz:
Objectives: Carbonic anhydrase (CA), 6-phosphogluconate dehydrogenase (6PGD) and thioredoxin reductase (TrxR) enzymes are the essential biological molecules needed for metabolic processes in all living cells. This study was designed to investigate the activities of CA, 6PGD and TrxR enzymes in the brain, kidney, liver, heart and testis tissues of the rats exposed to doxorubicin (DOX) and morin. Methods: Male Wistar albino rats were randomly divided into three groups as control, morin and DOX, each of them containing 7 rats. At the end of the experimental procedure, CA, 6PGD, and TrxR enzyme activities in tissues of rats were determined spectrophotometrically. Results: In our study, we observed that DOX activated CA enzyme in liver and kidney tissues while inhibiting CA enzyme in the other tissues, activated 6PGD enzyme in the kidney, liver and heart tissues, and inhibited the TrxR enzyme in all the tissues. In addition, morin activated CA enzyme in the liver tissue while inhibiting CA enzyme in the brain, heart and testis tissues. Morin activated 6PGD enzyme activity while it inhibited TrxR enzyme in all the tissues. Conclusion: The findings showed that doxorubicin and morin had similar properties in the tissues as to their effect on enzyme activities.
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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA AGGUL A, KUZU M, KANDEMİR F, KÜÇÜKLER S, caglayan c (2020). Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin. , 228 - 234. 10.33808/clinexphealthsci.632320
Chicago AGGUL AHMET GOKHAN,KUZU Müslüm,KANDEMİR Fatih Mehmet,KÜÇÜKLER Sefa,caglayan cuneyt Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin. (2020): 228 - 234. 10.33808/clinexphealthsci.632320
MLA AGGUL AHMET GOKHAN,KUZU Müslüm,KANDEMİR Fatih Mehmet,KÜÇÜKLER Sefa,caglayan cuneyt Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin. , 2020, ss.228 - 234. 10.33808/clinexphealthsci.632320
AMA AGGUL A,KUZU M,KANDEMİR F,KÜÇÜKLER S,caglayan c Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin. . 2020; 228 - 234. 10.33808/clinexphealthsci.632320
Vancouver AGGUL A,KUZU M,KANDEMİR F,KÜÇÜKLER S,caglayan c Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin. . 2020; 228 - 234. 10.33808/clinexphealthsci.632320
IEEE AGGUL A,KUZU M,KANDEMİR F,KÜÇÜKLER S,caglayan c "Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin." , ss.228 - 234, 2020. 10.33808/clinexphealthsci.632320
ISNAD AGGUL, AHMET GOKHAN vd. "Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin". (2020), 228-234. https://doi.org/10.33808/clinexphealthsci.632320
APA AGGUL A, KUZU M, KANDEMİR F, KÜÇÜKLER S, caglayan c (2020). Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin. Clinical and Experimental Health Sciences, 10(3), 228 - 234. 10.33808/clinexphealthsci.632320
Chicago AGGUL AHMET GOKHAN,KUZU Müslüm,KANDEMİR Fatih Mehmet,KÜÇÜKLER Sefa,caglayan cuneyt Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin. Clinical and Experimental Health Sciences 10, no.3 (2020): 228 - 234. 10.33808/clinexphealthsci.632320
MLA AGGUL AHMET GOKHAN,KUZU Müslüm,KANDEMİR Fatih Mehmet,KÜÇÜKLER Sefa,caglayan cuneyt Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin. Clinical and Experimental Health Sciences, vol.10, no.3, 2020, ss.228 - 234. 10.33808/clinexphealthsci.632320
AMA AGGUL A,KUZU M,KANDEMİR F,KÜÇÜKLER S,caglayan c Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin. Clinical and Experimental Health Sciences. 2020; 10(3): 228 - 234. 10.33808/clinexphealthsci.632320
Vancouver AGGUL A,KUZU M,KANDEMİR F,KÜÇÜKLER S,caglayan c Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin. Clinical and Experimental Health Sciences. 2020; 10(3): 228 - 234. 10.33808/clinexphealthsci.632320
IEEE AGGUL A,KUZU M,KANDEMİR F,KÜÇÜKLER S,caglayan c "Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin." Clinical and Experimental Health Sciences, 10, ss.228 - 234, 2020. 10.33808/clinexphealthsci.632320
ISNAD AGGUL, AHMET GOKHAN vd. "Alterations in Enzyme Activity of Carbonic Anhydrase, 6-phosphogluconate Dehydrogenase and Thioredoxin Reduc- tase in Rats Exposed to Doxorubicin and Morin". Clinical and Experimental Health Sciences 10/3 (2020), 228-234. https://doi.org/10.33808/clinexphealthsci.632320
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