Background: In this study, it was aimed to determine the personality characteristics and lead ership orientations of the nursing and midwifery students. Methods: The sample of this cross-sectional study consisted of 457 nursing and midwiferystudents studying at the faculty of health sciences of a university between April and June in2019. The data of the study was collected using the “Socio-Demographic Characteristics Formof the Individual”, “Bortner Self-Rating Scale Short Form” and “Leadership Orientation Scale”.Independent t-test and one-way ANOVA tests were used to analyze the data. Results: Of the students, 66.9% were nursing, 81.2% were female and the mean age was 20.66± 1.84 years. 79.8% of the students are graduated from anatolian high school. 59.7% of thestudents show A type personality. There was no significant difference in terms of leadershiporientations according to the age, parents’ education status, department, place of residenceand economic status. It was found that leadership orientations showed significant differenc es according to gender, personality type and degree of students’ class variables. When thestudents with A type personality exhibited human oriented, structure oriented and symbolicleadership orientations, male students showed structure oriented, political and symbolic lead ership orientations towards more than women. Conclusion: As a result, more than half of the students have A type personality types andstudents with A type personality traits have higher leadership orientation scores. When thepersonality types differ according to the academic grade point average of the students, lead ership orientations differ according to gender, personality type and class.