Yıl: 2022 Cilt: 5 Sayı: 1 Sayfa Aralığı: 21 - 27 Metin Dili: İngilizce DOI: 10.14744/ijmb.2021.28190 İndeks Tarihi: 06-07-2022

Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study

Öz:
Objectives: As childhood and adolescence are the periods when cardiovascular risk factors begin to emerge, this study aimed to investigate the serum lipid profiles of the pediatric population in age- and sex-specific partitions. Methods: The serum lipids were measured in 9613 pediatric samples from residual material in the Istanbul Public Health Laboratory with age groups stratified as 1-4 years, 5-9 years, 10-14 years, and 15-19 years. Results: The total-C and LDL-C were significantly high in girls aged 1-4 years, and total-C and LDL-C were significantly low in boys aged 15-19 years. Total-C levels of girls were also different at ages 1-4 and 15-19 years compared with boys. The girls also showed higher LDL-C levels at 1-4 and 15-19 years, non-HDL-C levels at 1-4 years, 5-9 years, and 15-19 years, and HDL-C at 15-19 years compared with the boys of the same age group. The prevalence of hypertriglyceridemia, hypercholesterolemia, and high LDL-C in the 15-19 age groups was significantly different between boys and girls. Conclusion: This study emphasizes the importance of determining lipid profiles during childhood and adolescence and taking preventive actions for cardiovascular diseases by implementing reliable age- and sex-specific cut-off values
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk Reduction in Children and Adolescents; National Heart, Lung, and Blood Institute. Expert panel on integrated guidelines for cardiovascular health and risk reduction in children and adolescents: summary report. Pediatrics 2011;128(Suppl 5):S213–56.
  • 2. Cholesterol Treatment Trialists' (CTT) Collaborators, Mihaylova B, Emberson J, Blackwell L, Keech A, Simes J, et al. The effects of lowering LDL cholesterol with statin therapy in people at low risk of vascular disease: meta-analysis of individual data from 27 randomised trials. Lancet 2012;380(9841):581–90.
  • 3. Jackson R, Lawes CM, Bennett DA, Milne RJ, Rodgers A. Treatment with drugs to lower blood pressure and blood cholesterol based on an individual's absolute cardiovascular risk. Lancet 2005;365(9457):434–41.
  • 4. Goff DC Jr, Lloyd-Jones DM, Bennett G, Coady S, D'Agostino RB, Gibbons R, et al; American College of Cardiology/American Heart Association Task Force on Practice Guidelines. 2013 ACC/AHA guideline on the assessment of cardiovascular risk: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines. Circulation 2014;129(25 Suppl 2):S49–73.
  • 5. Perk J, De Backer G, Gohlke H, Graham I, Reiner Z, Verschuren M, et al; European Association for Cardiovascular Prevention & Rehabilitation (EACPR); ESC Committee for Practice Guidelines (CPG). European Guidelines on cardiovascular disease prevention in clinical practice (version 2012). The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (constituted by representatives of nine societies and by invited experts). Eur Heart J 2012;33(13):1635–701.
  • 6. National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III) final report. Circulation 2002;106(25):3143–421.
  • 7. Juonala M, Magnussen CG, Venn A, Dwyer T, Burns TL, Davis PH, et al. Influence of age on associations between childhood risk factors and carotid intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study, the Childhood Determinants of Adult Health Study, the Bogalusa Heart Study, and the Muscatine Study for the International Childhood Cardiovascular Cohort (i3C) Consortium. Circulation 2010;122(24):2514–20.
  • 8. Tahmasebi H, Trajcevski K, Higgins V, Adeli K. Influence of ethnicity on population reference values for biochemical markers. Crit Rev Clin Lab Sci 2018;55(5):359–75.
  • 9. Bugge A, El-Naaman B, McMurray RG, Froberg K, Andersen LB. Tracking of clustered cardiovascular disease risk factors from childhood to adolescence. Pediatr Res 2013;73(2):245–9.
  • 10. Shaw JL, Binesh Marvasti T, Colantonio D, Adeli K. Pediatric reference intervals: challenges and recent initiatives. Crit Rev Clin Lab Sci 2013;50(2):37–50.
  • 11. Sniderman AD, Williams K, Contois JH, Monroe HM, McQueen MJ, de Graaf J, et al. A meta-analysis of low-density lipoprotein cholesterol, non-high-density lipoprotein cholesterol, and apolipoprotein B as markers of cardiovascular risk. Circ Cardiovasc Qual Outcomes 2011;4(3):337–45.
  • 12. Grundy SM, Stone NJ, Bailey AL, Beam C, Birtcher KK, Blumenthal RS, et al. 2018 AHA/ACC/AACVPR/AAPA/ABC/ACPM/ADA AGS/APhA/ASPC/NLA/PCNA Guideline on the management of blood cholesterol: executive summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. J Am Coll Cardiol 2019;73(24):3168–209.
  • 13. Kavey RE, Daniels SR, Lauer RM, Atkins DL, Hayman LL, Taubert K; American Heart Association. American Heart Association guidelines for primary prevention of atherosclerotic cardiovascular disease beginning in childhood. Circulation 2003;107(11):1562–6.
  • 14. Kit BK, Carroll MD, Lacher DA, Sorlie PD, DeJesus JM, Ogden CL. Trends in serum lipids among US youths aged 6 to 19 years, 1988-2010. JAMA 2012;308(6):591–600.
  • 15. de Ferranti SD, Steinberger J, Ameduri R, Baker A, Gooding H, Kelly AS, et al. Cardiovascular risk reduction in high-risk pediatric patients: a scientific statement from the American Heart Association. Circulation 2019;139(13):603–34.
  • 16. De Henauw S, Michels N, Vyncke K, Hebestreit A, Russo P, Intemann T, et al; IDEFICS consortium. Blood lipids among young children in Europe: results from the European IDEFICS study. Int J Obes (Lond) 2014;38 Suppl 2:S67–75.
  • 17. Vincelet C, Bruckert E, Le Corff J, Boisson M, Foucault C. The interest of cholesterol levels in young children. Study in a population of 4,697 children aged 4. Presse Med 2004;33(20):1417–20.
  • 18. Schienkiewitz A, Truthmann J, Ernert A, Wiegand S, Schwab KO, Scheidt-Nave C. Age, maturation and serum lipid parameters: findings from the German Health Survey for Children and Adolescents. BMC Public Health 2019;19:1627.
  • 19. Satman I, Omer B, Tutuncu Y, Kalaca S, Gedik S, Dinccag N, et al. TURDEP-II Study Group . Twelve-year trends in the prevalence and risk factors of diabetes and prediabetes in Turkish adults. Eur J Epidemiol 2013;28(2):169–80.
  • 20. Ucar B, Kılıc Z, Dinleyici EC, Colak O, Gunes E. Serum lipid profiles including non-high density lipoprotein cholesterol levels in Turkish school-children. Anadolu Kardiol Derg 2007;7(4):415–20.
  • 21. Toprak D, Bukulmez A, Dogan N, Oztekin O, Koken T. Evaluation of serum lipid profiles in Turkish children aged two to eighteen years. West Indian Med J 2014;63(6):588–95.
  • 22. Liu J, Dai Y, Yuan E, Li Y, Wang Q, Wang L, et al. Age-specific and sex-specific reference intervals for non-fasting lipids and apolipoproteins in 7260 healthy Chinese children and adolescents measured with an Olympus AU5400 analyser: a crosssectional study. BMJ Open 2019;9(8):e030201.
  • 23. Chandar V, Gidvani B, Gupta AK, Wilson CG, Sharma YV. Lipid Profile in normal healthy children. Med J Armed Forces India 1994;50(2):101–4.
  • 24. Haney EM, Huffman LH, Bougatsos C, Freeman M, Steiner RD, Nelson HD. Screening and treatment for lipid disorders in children and adolescents: systematic evidence review for the US Preventive Services Task Force. Pediatrics 2007;120(1):e189–214.
  • 25. CDC. Prevalence of Abnormal Lipid Levels Among Youths United States, 1999—2006. Morbidity and Mortality Weekly Report 2010;59(02);29–33. Available at:https://www.cdc.gov/mmwr/preview/mmwrhtml/mm5902a1.htm. Accessed Feb 15, 2021.
  • 26. Szternel L, Krintus M, Bergmann K, Derezinski T, Sypniewska G. Non-fasting lipid profile determination in presumably healthy children: Impact on the assessment of lipid abnormalities. PLoS ONE 2018;13(6):e0198433.
  • 27. Emerging Risk Factors Collaboration, Di Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray KK, et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA 2009;302(18):1993–2000.
  • 28. Baker RA, Forbes RA. Non-HDL cholesterol: a new endpoint in cardio-metabolic health monitoring. Prim Care Companion J Clin Psychiatry 2010;12(5):PCC.09l00940.
  • 29. Sniderman AD, Furberg CD, Keech A, Roeters van Lennep JE, Frohlich J, Jungner I, et al. Apolipoproteins versus lipids as indices of coronary risk and as targets for statin treatment. Lancet. 2003;361(9359):777–80.
  • 30. Holewijn S, Heijer den M, Swinkels DW, Stalenhoef AFH, Graaf de J. Apolipoprotein B, non-HDL cholesterol and LDL cholesterol for identifying individuals at increased cardiovascular risk. J Intern Med 2010;268(6):567–77.
  • 31. Bansal S, Buring JE, Rifai N, Mora S, Sacks FM, Ridker PM. Fasting compared to nonfasting triglycerides and risk of cardiovascular events in women. JAMA 2007;298(3):309–16.
  • 32. Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA 2007;298(3):299–308.
  • 33. Higgins V, Asgari S, Chan MK, Adeli K. Pediatric reference intervals for calculated LDL-cholesterol, and remnant cholesterol in the healthy CALIPER cohort. Clin Chim Acta 2018;486:129–34.
  • 34. Steiner MJ, Skinner AC, Perrin EM. Fasting might not be necessary before lipid screening: a nationally representative crosssectional study. Pediatrics 2011;128(3):463–70.
  • 35. Langsted A, Nordestgaard BG. Nonfasting lipids, lipoproteins, and apolipoproteins in individuals with and without diabetes: 58434 individuals from the Copenhagen General Population Study. Clin Chem 2011;57(3):482–9.
  • 36. National Clinical Guideline Centre (UK). Lipid modification: cardiovascular risk assesment and the modification of blood lipids for the primary and secondary prevention of cardiovascular disease. NICE Clinical Guidelines, No. 181. Available at: http://www. ncbi.nlm. nih.gov/books/NBK248067/. Accessed Feb 15, 2021.
  • 37. Nordestgaard BG, Langsted A, Mora S, Kolovou G, Baum H, Bruckert E, et al. Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cutpoints-a joint consensus statement from the european atherosclerosis society and european federation of clinical chemistry and laboratory medicine. Clin Chem 2016;62(7):930–46
APA Eroğlu İçli H, Kaytaz A, Ademoglu E, Genc S (2022). Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study. , 21 - 27. 10.14744/ijmb.2021.28190
Chicago Eroğlu İçli Hacer,Kaytaz Arif Murat,Ademoglu Evin,Genc Sema Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study. (2022): 21 - 27. 10.14744/ijmb.2021.28190
MLA Eroğlu İçli Hacer,Kaytaz Arif Murat,Ademoglu Evin,Genc Sema Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study. , 2022, ss.21 - 27. 10.14744/ijmb.2021.28190
AMA Eroğlu İçli H,Kaytaz A,Ademoglu E,Genc S Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study. . 2022; 21 - 27. 10.14744/ijmb.2021.28190
Vancouver Eroğlu İçli H,Kaytaz A,Ademoglu E,Genc S Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study. . 2022; 21 - 27. 10.14744/ijmb.2021.28190
IEEE Eroğlu İçli H,Kaytaz A,Ademoglu E,Genc S "Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study." , ss.21 - 27, 2022. 10.14744/ijmb.2021.28190
ISNAD Eroğlu İçli, Hacer vd. "Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study". (2022), 21-27. https://doi.org/10.14744/ijmb.2021.28190
APA Eroğlu İçli H, Kaytaz A, Ademoglu E, Genc S (2022). Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study. International Journal of Medical Biochemistry, 5(1), 21 - 27. 10.14744/ijmb.2021.28190
Chicago Eroğlu İçli Hacer,Kaytaz Arif Murat,Ademoglu Evin,Genc Sema Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study. International Journal of Medical Biochemistry 5, no.1 (2022): 21 - 27. 10.14744/ijmb.2021.28190
MLA Eroğlu İçli Hacer,Kaytaz Arif Murat,Ademoglu Evin,Genc Sema Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study. International Journal of Medical Biochemistry, vol.5, no.1, 2022, ss.21 - 27. 10.14744/ijmb.2021.28190
AMA Eroğlu İçli H,Kaytaz A,Ademoglu E,Genc S Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study. International Journal of Medical Biochemistry. 2022; 5(1): 21 - 27. 10.14744/ijmb.2021.28190
Vancouver Eroğlu İçli H,Kaytaz A,Ademoglu E,Genc S Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study. International Journal of Medical Biochemistry. 2022; 5(1): 21 - 27. 10.14744/ijmb.2021.28190
IEEE Eroğlu İçli H,Kaytaz A,Ademoglu E,Genc S "Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study." International Journal of Medical Biochemistry, 5, ss.21 - 27, 2022. 10.14744/ijmb.2021.28190
ISNAD Eroğlu İçli, Hacer vd. "Importance of detecting hyperlipidemia in children and adolescents to manage cardiovascular risk: A cross-sectional study". International Journal of Medical Biochemistry 5/1 (2022), 21-27. https://doi.org/10.14744/ijmb.2021.28190