The research has been conducted to investigate the self-learning readiness, clinical decision-making and reflective thinking levels of nursing students who take surgery lessons. The research has been carried out with the participation of 141 students who took the “Surgical Disease Nursing” course at a university in the Aegean region. The data have been collected by; Descriptive Characteristics Form, Self-Learning Readiness Scale, Nursing Clinical Decision Making Scale and Reflective Thinking Level Scale. Number, percentage, Mann-Whitney U, Kruskall Wallis and Spearman Correlation analyzes have been used in the evaluation of the data. The average age of the students is 20.39±1.69 and 71.6% (n=101) of them are girls. The scale mean scores of the students were Self-Learning Readiness Scale is 154.34±16.61, Nursing Clinical Decision-Making Scale is 145.90±11.90, Reflective Thinking Scale is 57.02±8.13. The grade point average of 70% of the students is between 2.00 and 3.00. A low level and positive significant correlation has been found between the students' clinical decision-making and self-learning readiness (r=0.360) and reflective thinking level (r=0.212), self-learning readiness and reflective thinking level scales (r =0.346) (p <0.05). According to the research results, the students’ mean scores from all scales are above average. It has been observed that the students were ready to self learning, their clinical decision making skills were improved and they were able to use reflective thinking in this process. It is suggested that concept maps and reflective thinking practices can be used effectively in applied lessons in order to strengthen the relationship between these skills.