Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme

Gumus, Hatice Hale

doi:10.17827/aktd.1246260

Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme

Hatice Hale GÜMÜŞ (Çukurova Üniversitesi, Tıp Fakültesi, Tıbbi Mikrobiyoloji Anabilim Dalı, Adana, Türkiye)

Arşiv Kaynak Tarama Dergisi

8 0

Yıl: 2023 Cilt: 32 Sayı: 1 Sayfa Aralığı: 1 - 9 Metin Dili: Türkçe DOI: 10.17827/aktd.1246260 İndeks Tarihi: 01-11-2023

Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme

Öz:

Antimikrobiyal direnç (AMD) ile ilişkili morbidite ve mortalite küresel bir halk sağlığı sorunudur. Sağlık hizmeti ilişkili enfeksiyonlarda sık olarak görülen vankomisine dirençli Enterococcus faecium (VRE), Dünya Sağlık Örgütü’nün AMD’i olan öncelikli patojenler listesinde yüksek öncelik verdiği bir Gram pozitif koktur. Son zamanlarda Türkiye’de invaziv enfeksiyonlarda VRE izolasyon oranı %15.8 bildirilmiştir. Vankomisine direncin ana mekanizması, hedef bölgedeki D-Alanil-D-Alanin terminal molekülünün değişmesi ve ilacın affinitesinin azalmasıdır. Vankomisin direncinden sorumlu olan van geni kromozomal olarak kodlanmakta veya plazmid, transpozon gibi mobil genetik elemanlar ile kazanılmaktadır. Yayılımındaki ana mekanizma, mobil genetik elemanların Enterokoklar veya Staphylococcus aereus gibi farklı tür bakteriler arasında transfer edilebilmeleridir. Bu derlemede PubMed ve Web of Science veritabanlarında “Vankomisin-dirençli Enterococcus faecium”, “Vankomisin direnç mekanizmaları”, “Gram pozitif koklarda vankomisin direnci” terimleri ile arama yapılarak elde edilen literatür verileri özetlenmiş ve önerilerle birlikte kısaca tartışılmıştır.

Anahtar Kelime: Antimikrobiyal direnç vankomisin direnci E. faecium vanA vanB

Vancomycin-resistant Enterococcus faecium: A Brief Review

Öz:

Morbidity and mortality associated with antimicrobial resistance is a global public health problem. Vancomycin- resistant Enterococcus faecium, which is frequently seen in healthcare-associated infections, is a Gram-positive cocci that the he World Health Organization has given high priority on its list of priority pathogens with antimicrobial resistance. Recently, the rate of vancomycin-resistant Enterococcus faecium isolation in invasive infections has been reported as 15.8% in Turkey. The main mechanism of resistance to vancomycin is alteration of the D-alanyl-D-alanine terminal molecule in the target region, and decreased affinity for the antibiotic. The van gene responsible for vancomycin resistance is either chromosomally encoded or acquired by mobile genetic elements such as plasmid and transposon. The main mechanism of its spread is that mobile genetic elements can be transferred within the same species or between different bacteria like Staphylococcus aereus. In this review, data, extracted by PubMed and Web of Science Databases searching with the terms "Vancomycin-resistant Enterococcus faecium", "Vancomycin resistance mechanisms", "vancomycin resistance in Gram-positive cocci" is summarized and briefly discussed with recommendations.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık

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APA	Gumus H (2023). Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme. , 1 - 9. 10.17827/aktd.1246260
Chicago	Gumus Hatice Hale Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme. (2023): 1 - 9. 10.17827/aktd.1246260
MLA	Gumus Hatice Hale Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme. , 2023, ss.1 - 9. 10.17827/aktd.1246260
AMA	Gumus H Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme. . 2023; 1 - 9. 10.17827/aktd.1246260
Vancouver	Gumus H Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme. . 2023; 1 - 9. 10.17827/aktd.1246260
IEEE	Gumus H "Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme." , ss.1 - 9, 2023. 10.17827/aktd.1246260
ISNAD	Gumus, Hatice Hale. "Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme". (2023), 1-9. https://doi.org/10.17827/aktd.1246260

APA	Gumus H (2023). Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme. Arşiv Kaynak Tarama Dergisi, 32(1), 1 - 9. 10.17827/aktd.1246260
Chicago	Gumus Hatice Hale Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme. Arşiv Kaynak Tarama Dergisi 32, no.1 (2023): 1 - 9. 10.17827/aktd.1246260
MLA	Gumus Hatice Hale Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme. Arşiv Kaynak Tarama Dergisi, vol.32, no.1, 2023, ss.1 - 9. 10.17827/aktd.1246260
AMA	Gumus H Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme. Arşiv Kaynak Tarama Dergisi. 2023; 32(1): 1 - 9. 10.17827/aktd.1246260
Vancouver	Gumus H Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme. Arşiv Kaynak Tarama Dergisi. 2023; 32(1): 1 - 9. 10.17827/aktd.1246260
IEEE	Gumus H "Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme." Arşiv Kaynak Tarama Dergisi, 32, ss.1 - 9, 2023. 10.17827/aktd.1246260
ISNAD	Gumus, Hatice Hale. "Vankomisine Dirençli Enterococcus faecium: Kısa Bir Derleme". Arşiv Kaynak Tarama Dergisi 32/1 (2023), 1-9. https://doi.org/10.17827/aktd.1246260