This study was conducted to examine the effect of safety culture on safety performance of health personnel working in a state hospital. The study was conducted at Gümüşhane State Hospital between 25.03.2019-28.06.2019. The study group consisted of 119 people who were actively working in the hospital on the dates of the study (doctornurse- health technician) and who voluntarily agreed to participate in the study. The study data were collected by face-to-face interview technique. Institutional permission and scientific research and publication ethics committee approval permission required for the study were obtained. The ‘Safety Culture and Safety Performance’ questionnaire form developed by Dursun in 2011 was used to collect the data. In the study, it was concluded that there was no statistically significant difference between the safety culture and safety performance of the employees, and that there were significant positive relationships towards safety culture. No significant difference was found between the mean safety awareness scores of the participants with 1-5 years of work at the workplace and the mean safety awareness scores of the participants with 5 or more years of work at the workplace.(p=.009). It is recommended that each organization should create the necessary safety culture in line with the occupational safety goals of the organization and update it by providing the necessary trainings on this subject.