In the markets, buyers and sellers do not always have the same knowledge. While this provides an advantage in terms of the party holding the right information, it is a disadvantage for the party that lacks it. Health care is one of the areas where knowledge is intense. Because the relationship between the service providers and the fields is based on the basis of knowledge. It is not always possible for patients receiving services, diseases and receivables to have full and detailed information about the service. On the other hand, physicians have more knowledge about diseases and treatments of patients. This leads to information asymmetry and economic losses due to the fact that both sides do not have the same information (symmetric) in the health care market. This study investigates the economic effects of physical condition, communication, ethics and trust in the relationship between patient and physician due to information asymmetry. The universe of the research constitutes the doctors working in the province of Çanakkale and the patients receiving services from these physicians. In the scope of the study, 172 physicians and 348 patients were reached and a questionnaire was applied. According to the results of the study, it was determined that there is a significant difference between physicians and patients in terms of perception level. In the use of services, health information levels have been found to be effective besides education level. Communication and trust between the patient and the physician are related to the diagnosis and treatment process. This is changing the tendency of patients to get services. The changes in the tendency to receive health care services lead to unnecessary and excessive use of the services by the patients, as well as loss of time, excessive use of transportation systems and loss of working time. In terms of physicians, it also causes economic loss and cost increase such as loss of work, waste of time for other patients, loss of consumables and medical equipment.