Objectives: Rational drug use is defined as the use of drugs that meet the clinical needs of patients at doses that meet their individual needs, for a sufficient period of time, at the lowest cost to themselves and the community. This study was carried out to examine the patients’ knowledge, attitude and behaviors towards rational drug use. Materials and Methods: A total of 400 patients admitted to the University of Health Sciences, Antalya Training and Research Hospital Family Medicine outpatient clinic were included in the study.The study was planned as a descriptive study. Sample size was calculated as 384 with 95% confidence interval and 95% power. Level of significance was taken as p<0,05.Results: Two hundred twenty‐six of the participants were female (56.50%) and 174 (43.50%). Age range was 18‐88. The behavior of the participants in patients were: 79.50% to go to the doctor, 38.50% to use home drugs, 24.75% to apply to the pharmacy. 60.25% of the participants were using prescription drugs according to the doctor's recommendation, 25.25% of the drugs were stopped after the complaints, 14.25% of them were using irregularly. The rate of drug use at home was 84.25%. 55.25% of those who had medicines at home had the drug expiration date and 32.25% had paid attention to the drug side effects. 76.25% analgesics, 32.75% stomach medications and 16.50% antibiotics were the most commonly used treatments in the home.Conclusion: As a result of our research, it was determined that the participants did not comply with the principles of rational drug use. To raise awareness of rational drug use and to correct mistakes; family physicians should provide appropriate counseling on drugs to be used, and they should devote sufficient time to patient education.