Increases or decreases in the value of any macroeconomic variable in the economic structure may affect other macroeconomic variables directly or indirectly. In this context, it is possible to say that there are significant interactions between the interest rate, inflation rate and exchange rate, and mutually. The way to achieve a successful economic growth performance is to achieve a balance and harmony between the macroeconomic variables subject to the research. Ensuring this harmony is extremely difficult. In the study, which was prepared to reveal the causal relationship between the interest rate, inflation rate and exchange rate in Turkey, the analysis was carried out using monthly data for the period 2011 - 2021 obtained from the electronic data distribution center (EVDS) system of Central Bank of the Republic of Turkey. In the analysis, first of all, the long-term cointegration relations of the series, whose stationarity at the I (1) level were determined by the unit root tests, were tested by the Johansen Cointegration test. With the determination of long-term cointegration, which is a prerequisite of causality analysis, the direction of causality between interest rate, exchange rate and inflation was determined by causality analysis based on Vector Error Correction (VEC) Model. According to the results of the analysis, while there is a bidirectional relationship between foreign exchange and inflation in the short run, a unidirectional causality from interest rates to inflation figures has been determined. In the long run, only one-way causality was found from inflation to exchange rate.