The research was carried out to determine the life style and behavioral changes of nurses during the pandemic period. The descriptive study was conducted between April and May 2021 at the Research and Practice Hospital of Bozok University with the participation of 227 nurses. Data were collected using the 'Descriptive Information Form' and the 'Lifestyle Behavior Scale (YBDÖ)'. ANOVA test, Mann Whitney-U test, Kruskal Wallis-H test and Mann Whitney-U Post-Hoc test with Bonferroni correction were used for data analysis. Of the nurses participating in the research, 81.9% were women, 44.9% were married, 64.3% were graduates of an under graduate program, and 30.4% were working in intensive care services. Thirty-seven percent of the nurses were diagnosed with COVID-19. The study revealed that there were increases in both healthy and unhealthy nutrition, the anxiety and stress levels, and their social support of the nurses, with no change in their physical activity levels and behaviors of harmful habits. It was found that was a positive change in the eating habits of the elderly people compared to the younger ones, those with services of 11 years and above compared to those with less service, the married compared to the singles, and the people with COVID-19 compared to those who did not have it. The increase in the perception of social support of those with COVID-19 is morepronounced. In COVID-19, unhealthy diets and physical activities of employees in emergency, internal and surgical services have increased. Positive changes in life style behavior of nurses should be supported by healthinstitutions. Attention should be paid to the positive trend in the life style behaviors of nurses.