The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters
Yıl: 2022 Cilt: 28 Sayı: 1 Sayfa Aralığı: 6 - 10 Metin Dili: İngilizce DOI: 10.4274/tod.galenos.2021.66934 İndeks Tarihi: 31-05-2023
The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters
Öz: Objective: The pathogenesis and progression of osteoarthritis (OA) are related to low-grade inflammation. Objectives were conducted; first to investigate whether neutrophil-to-lymphocyte, platelet-to-lymphocyte ratios are appropriate parameters to determine low-grade inflammation in knee OA. The second objective was to evaluate whether vitamin-D deficiency contributes to the severity of OA and these inflammatory parameters as well. Materials and Methods: 623 patients with knee-pain were evaluated retrospectively, 136 patients with knee OA were included. 25-hidroxyvitamin D, complete-blood count, C-reactive protein, erythrocyte-sedimentation rate, knee radiographs (Kellgren-Lawrance scale) was recorded. Results: “Vitamin-D deficiency” was detected in 52.2% of all patients (<20 ng/mL). Blood parameters and severity of knee OA was found similar between patients with “25-hidroxyvitamin D <20 nanogramme/mililiters” and “≥20 nanogramme/mililiters.” 59.5% of patients had “mild OA,” 40.4% of patients had “moderate-to-severe OA.” All parameters were found similar between these two groups, only age was found significantly higher (p<0.001) in patients “moderate-to-severe OA.” Conclusion: Neutrophil to lymphocyte, platelet to lymphocyte ratios are not found as appropriate parameters in determining low-gradeinflammation in knee OA; moreover there were found no relation between vitamin-D deficiency and both radiological severity and inflammation parameters in knee OA.
Anahtar Kelime: D Vitamini, Diz Osteoartriti Şiddeti ve Enflamatuvar Belirteçler Arasındaki İlişki
Öz: Amaç: Osteoartritin (OA) patogenezi ve progresyonunun düşük dereceli enflamasyon ile ilişkili olduğu bilinmektedir. Bu çalışmanın amacı öncelikle nötrofil/lenfosit oranı ve platelet/lenfosit oranlarının OA’daki düşük düzey enflamasyonunu belirlemede uygun parametreler olup olmadığını araştırmaktır. İkincil amaç da D vitamini eksikliğinin, OA’nın radyolojik şiddetine ve enflamatuvar parametrelere katkıda bulunup bulunmadığını araştırmaktır. Gereç ve Yöntem: Diz ağrısı ile başvuran toplam 623 hasta dosyası incelenerek, çalışmaya dahil edilme kriterlerine uyan, 136 diz osteoartritli hasta dosyası çalışmaya dahil edilmiştir. 25-hidroksivitamin D, tam-kan sayımı, eritrosit sedimentasyon-hızı, C-reaktif protein ve diz radyografilerindeki Kellgren-Lawrance evreleri kayıt edilmiştir. Bulgular: Çalışmamıza alınan hastaların %52,2’sinde D vitamini eksikliği saptanmıştır (<20 ng/mL). D vitamini değeri <20 ng/mL ve ≥20 ng/ mL olan hastalar arasında ne OA şiddeti ne de enflamasyon parametreleri açısından fark saptanmamıştır. Radyografik osteoartrit hastaların %59,5’inde hafif düzeyde, %40,4’ünde ise orta-şiddetli düzeyde saptanmıştır. Yaş açısından değerlendirildiğinde ise, orta-şiddetli OA olan hastaların yaşı, istatistiksel olarak hafif OA’sı mevcut olan hastalara göre fazla bulunmuştur (p<0,001). Yaş dışındaki parametreler açısından, hafif ve orta-şiddetli OA’sı olan hastalarda fark saptanmamıştır. Sonuç: Bu çalışmada, nötrofil/lenfosit oranı ve platelet/lenfosit oranının, diz osteoartritindeki düşük dereceli enflamasyonu belirlemede yetersiz olduğu sonucuna ulaşılmıştır. Ayrıca D vitamini eksikliğinin, radyolojik olarak OA şiddeti ve enflamatuvar parametreler üzerine etkisi saptanmamıştır
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Bakılan F, Ortanca B (2022). The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters. , 6 - 10. 10.4274/tod.galenos.2021.66934 |
| Chicago | Bakılan Fulya,Ortanca Burcu The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters. (2022): 6 - 10. 10.4274/tod.galenos.2021.66934 |
| MLA | Bakılan Fulya,Ortanca Burcu The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters. , 2022, ss.6 - 10. 10.4274/tod.galenos.2021.66934 |
| AMA | Bakılan F,Ortanca B The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters. . 2022; 6 - 10. 10.4274/tod.galenos.2021.66934 |
| Vancouver | Bakılan F,Ortanca B The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters. . 2022; 6 - 10. 10.4274/tod.galenos.2021.66934 |
| IEEE | Bakılan F,Ortanca B "The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters." , ss.6 - 10, 2022. 10.4274/tod.galenos.2021.66934 |
| ISNAD | Bakılan, Fulya - Ortanca, Burcu. "The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters". (2022), 6-10. https://doi.org/10.4274/tod.galenos.2021.66934 |
| APA | Bakılan F, Ortanca B (2022). The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters. Türk Osteoporoz Dergisi, 28(1), 6 - 10. 10.4274/tod.galenos.2021.66934 |
| Chicago | Bakılan Fulya,Ortanca Burcu The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters. Türk Osteoporoz Dergisi 28, no.1 (2022): 6 - 10. 10.4274/tod.galenos.2021.66934 |
| MLA | Bakılan Fulya,Ortanca Burcu The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters. Türk Osteoporoz Dergisi, vol.28, no.1, 2022, ss.6 - 10. 10.4274/tod.galenos.2021.66934 |
| AMA | Bakılan F,Ortanca B The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters. Türk Osteoporoz Dergisi. 2022; 28(1): 6 - 10. 10.4274/tod.galenos.2021.66934 |
| Vancouver | Bakılan F,Ortanca B The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters. Türk Osteoporoz Dergisi. 2022; 28(1): 6 - 10. 10.4274/tod.galenos.2021.66934 |
| IEEE | Bakılan F,Ortanca B "The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters." Türk Osteoporoz Dergisi, 28, ss.6 - 10, 2022. 10.4274/tod.galenos.2021.66934 |
| ISNAD | Bakılan, Fulya - Ortanca, Burcu. "The Relation Between Vitamin D, Severity of Knee Osteoarthritis and Inflammatory Parameters". Türk Osteoporoz Dergisi 28/1 (2022), 6-10. https://doi.org/10.4274/tod.galenos.2021.66934 |
