Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey

ÖZBEK, Ahmet; EROL, Serpil; Parlak, Mehmet; YILMAZ İBA, Sibel

Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey

Sibel YILMAZ İBA, (Erzurum Bölge Eğitim ve Araştırma Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, Erzurum, Türkiye)

Serpil EROL, (Haydarpaşa Numune Eğitim ve Araştırma Hastanesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Kliniği, İstanbul, Türkiye)

Ahmet ÖZBEK, (Sakarya Üniversitesi, Tıp Fakültesi, Eğitim ve Araştırma Hastanesi, Klinik Mikrobiyoloji Anabilim Dalı, Sakarya, Türkiye)

Mehmet PARLAK (Atatürk Üniversitesi, Tıp Fakültesi, İnfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Anabilim Dalı, Erzurum, Türkiye)

Turkish Journal of Medical Sciences

1 0

Yıl: 2015 Cilt: 45 Sayı: 1 Sayfa Aralığı: 70 - 75 Metin Dili: İngilizce İndeks Tarihi: 29-07-2022

Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey

Öz:

Background/aim: To investigate the distribution of viral genotypes, the extrahepatic manifestations, and the relationship between genotypes and extrahepatic manifestations in patients with chronic hepatitis C. Materials and methods: The study included 62 treatment-naive patients with chronic hepatitis C infection. Genotype determination was performed by DNA sequencing analysis. To investigate extrahepatic manifestations, the patients data, recorded prospectively during the pretreatment period, were analyzed. Results: Genotype determination was successful in 74.2% of the cases. All patients were infected with hepatitis C virus (HCV) genotype 1b. At least 1 extrahepatic manifestation was identified in 37.1% of the patients. The most frequent clinical manifestations were type II diabetes mellitus (8.1%) and arthralgia or arthritis (8.0%). There was no relationship between extrahepatic manifestations and fibrosis or transaminase levels, but female sex and advanced age were risk factors. Because all patients were infected with the same genotype, the relationship between extrahepatic manifestations and genotype could not be examined. Conclusion: HCV genotype 1b is predominant in patients with chronic hepatitis C in the Eastern Anatolian Region of Turkey. In total, 37.1% of the patients had at least 1 extrahepatic manifestation. Female sex and advanced age were risk factors for having extrahepatic manifestations.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	YILMAZ İBA S, EROL S, ÖZBEK A, Parlak M (2015). Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey. , 70 - 75.
Chicago	YILMAZ İBA Sibel,EROL Serpil,ÖZBEK Ahmet,Parlak Mehmet Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey. (2015): 70 - 75.
MLA	YILMAZ İBA Sibel,EROL Serpil,ÖZBEK Ahmet,Parlak Mehmet Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey. , 2015, ss.70 - 75.
AMA	YILMAZ İBA S,EROL S,ÖZBEK A,Parlak M Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey. . 2015; 70 - 75.
Vancouver	YILMAZ İBA S,EROL S,ÖZBEK A,Parlak M Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey. . 2015; 70 - 75.
IEEE	YILMAZ İBA S,EROL S,ÖZBEK A,Parlak M "Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey." , ss.70 - 75, 2015.
ISNAD	YILMAZ İBA, Sibel vd. "Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey". (2015), 70-75.

APA	YILMAZ İBA S, EROL S, ÖZBEK A, Parlak M (2015). Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey. Turkish Journal of Medical Sciences, 45(1), 70 - 75.
Chicago	YILMAZ İBA Sibel,EROL Serpil,ÖZBEK Ahmet,Parlak Mehmet Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey. Turkish Journal of Medical Sciences 45, no.1 (2015): 70 - 75.
MLA	YILMAZ İBA Sibel,EROL Serpil,ÖZBEK Ahmet,Parlak Mehmet Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey. Turkish Journal of Medical Sciences, vol.45, no.1, 2015, ss.70 - 75.
AMA	YILMAZ İBA S,EROL S,ÖZBEK A,Parlak M Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey. Turkish Journal of Medical Sciences. 2015; 45(1): 70 - 75.
Vancouver	YILMAZ İBA S,EROL S,ÖZBEK A,Parlak M Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey. Turkish Journal of Medical Sciences. 2015; 45(1): 70 - 75.
IEEE	YILMAZ İBA S,EROL S,ÖZBEK A,Parlak M "Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey." Turkish Journal of Medical Sciences, 45, ss.70 - 75, 2015.
ISNAD	YILMAZ İBA, Sibel vd. "Distribution of viral genotypes and extrahepatic manifestations in patients with chronic hepatitis C in Eastern Turkey". Turkish Journal of Medical Sciences 45/1 (2015), 70-75.