Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital
Yıl: 2019 Cilt: 25 Sayı: 2 Sayfa Aralığı: 59 - 61 Metin Dili: Türkçe DOI: 10.4274/vhd.galenos.2019.2019.0011 İndeks Tarihi: 10-03-2020
Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital
Öz: Objectives: The aim was to support both the clinical treatment and management and also to contribute to the epidemiological understanding of the hepatitis C virüs (HCV) genotype in our region. Materials and Methods: HCV genotyping was performed with suspected HCV infection in İzmir Katip Çelebi University, Atatürk Training and Research Hospital, Medical Microbiology Molecular Laboratory. Genotyping of the samples identified as positive for HCV-RNA was performed by Bosphore HCV Genotyping Kit v3.Results: HCV genotyping results were obtained in 198 (75.8%) of 261 samples. Genotype 1 was found in 158 (79.8%) of the 198 samples, genotype 3 was found in 23 (11.6%), genotype 4 in 12 (6%) and genotype 2 in 3 (1.5%). Genotype 5 was detected in 2 (1%) individuals and one of whom was found to be a foreign national. Four of the 12 individuals identified as genotype 4 were found to be foreign nationals. Of the 158 genotype 1, 131 (82.9%) were identified as genotype 1b and 21 (13. 3%) 1a.Conclusion: In our hospital, the most prevalent genotype is 1. This result is compatible with our country.
Anahtar Kelime: Konular:
İzmir Atatürk Eğitim ve Araştırma Hastanesine Başvuran Hastalarda Hepatitis C Virüs Genotip Sonuçlarının Değerlendirilmesi
Öz: Amaç: Bu çalışmada, hepatit V vrüs (HCV)-RNA pozitif hastaların HCV genotip tayinleri retrospektif incelenerek hem klinik tedavi yönetimine destek vermek hem de bölgemizdeki HCV genotip epidemiyolojisine katkı sağlamak amaçlanmıştır. Gereç ve Yöntemler: İzmir Katip Çelebi Üniversitesi, Atatürk Eğitim ve Araştırma Hastanesi Tıbbi Mikrobiyoloji Moleküler Laboratuvarına HCV genotipleme istenen ve sonuçları çıkanlar çalışmaya alındı. HCV-RNA pozitif olarak tespit edilen örneklerin genotipleme çalışması hepatit C virüsü RNA’sının tüm genotiplerini saptayabilen Bosphore HCV Genotyping Kit v3 ile yapıldı. Bulgular: HCV genotiplendirme çalışılan 261 örneğin 198 (%75,8) tanesinde sonuç elde edilmiştir. Yüz doksan sekiz örneğin 158’inde (%79,8) genotip 1, 23ünde (%11,6) genotip 3, 12’sinde (%6) genotip 4 ve 3’ünde (%1,5) genotip 2 saptanmıştır. İki (%1) kişide de genotip 5 tespit edilmiş ve bunlardan birinin yabancı uyruklu olduğu görülmüştür. Genotip 4 olarak tespit edilen 12 kişiden 4’ünün yabancı uyruklu olduğu görülmüştür. Genotip 1 olan 158 örneğin 131’i (%82,9) genotip 1b 21’i (%13,3) 1a olarak tespit edilmiştir. Sonuç: Hastanemizde en sık genotip 1 görülür ve sonuçlar ülkemizle uyumludur.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Kaya S, Arıdoğan B, Çetin E, Adiloğlu AK, Demirci M. Comparison of polimerase chain reaction and serological methods in the diagnosis of hepatitis C virus infection. SDU Tıp Fakültesi Dergisi. 2007;14:10-14.
- 2. Kaya S, Alanoğlu G, Polat M, Sipahi T. Süleyman Demirel Üniversitesi Tıp Fakültesi Kan Merkezi’nin 2000-2007 yılları tarama test sonuçları. SDU Üniversitesi Tıp Fakültesi Dergisi. 2009;16:13-15.
- 3. Ural O, Arslan U, Fındık D. The distribution of hepatıtıs C virus genotype in the Konya Region, Turkey. Turkish Journal of Infection. 2007;21:175-181.
- 4. Kayman T, Karakükçü Ç, Karaman A, Gözütok F. Kayseri bölgesinde Hepatit C virüs enfeksiyonunun genotip dağılımı. Türk Mikrobiyol Cem Derg. 2012;42:21-26.
- 5. Sağlık İ, Mutlu D, Öngüt G İnan D, Öğünç D, Can Sarınoğlu R, Özhak Baysan B, Meral Gültekin M, Çolak D. Akdeniz Üniversitesi Hastanesinde kronik hepatit C enfeksiyonu olan hastalarda hepatit C virus genotipleri. Beş yıllık sonuçların değerlendirilmesi. Mikrobiyol Bul. 2014;48:429-437.
- 6. Gower E, Estes C, Blach S, Razavi-Shearer K, Razavi H. Global epidemiology and genotype distribution of the hepatitis C virus infection. J Hepatol. 2014;61:45-57.
- 7. Magiorkinis G, Magiorkinis E, Paraskevis D, et al. The global spread of hepatitis C virus 1a and 1b: a phylodynamic and phylogeographic analysis. PLoS Med. 2009;6:e1000198.
- 8. Kirişçi Ö, Çalışkan A, Alkış Koçtürk S, Erdoğmus P, Gül M. The relationship between distribution of HCV-RNA and ALT-AST Levels with genotypes of hepatitis C virus infected patients. Viral Hepatitis Journal 2013;19:67-70.
- 9. Sağlık İ, Mutlu D, Öngut G, İnan D, Öğünç D, Can Sarinoğlu R, Özhak Baysan B, Gültekin M, Çolak D. Distribution of hepatitis C virus genotypes among patients with chronic hepatitis C infection in Akdeniz University Hospital, Antalya, Turkey: A five-year evaluation. Mikrobiyol Bul. 2014;48:429-437.
- 10. Buruk CK, Bayramoğlu G, Reis A, Kaklıkkaya N, Tosun I, Aydın F. Determination of hepatitis C virus genotypes among hepatitis C patients in Eastern Black Sea region, Turkey. Mikrobiyol Bul. 2013;47:650-657.
- 11. Çiftci İH, Er H, Aşık G, Aktepe OC, Altındiş M. Hepatit C virusu (HCV) RNA pozitif olgularda genotip dağılımı. Kocatepe Tıp Dergisi. 2009;10:21-24.
- 12. Gökahmetoğlu S, Atalay MA, Kılınç A. Hepatit C virus genotiplerinin pirosekanslama yöntemi ile belirlenmesi. Erciyes Tıp Dergisi. 2011;33:99-102.
- 13. Altuğlu I, Sertöz R, Aksoy A, Gürsel D, Tüzüner U, Günşar F. Possible transmission risks and genotype distribution of hepatitis C virus infection in Western Turkey. Turk J Gastroenterol 2013;24:349-355.
- 14. Buket CA, Ayşe A, Selçuk K, Süleyman Ö, Emel SÇ. Comparison of HCV core antigen and anti-HCV with HCV RNA results. Afr Health Sci. 2014;14:816-820.
- 15. Uzun BK, Er H, Güngör S, Şener AG, Kaya S. The evaluation of Recombinant Immunoblot assay (RIBA) and HCV-RNA test results in patients with low titer anti-HCV positivity. Journal of Clinical and Experimental Investigations 2014;5: 553-556.
| APA | Kaya S, AFŞAR İ, AKSOY GÖKMEN A, sener a, SAYINER A (2019). Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital. , 59 - 61. 10.4274/vhd.galenos.2019.2019.0011 |
| Chicago | Kaya Selçuk,AFŞAR İlhan,AKSOY GÖKMEN AYŞEGÜL,sener asli gamze,SAYINER AYCA ARZU Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital. (2019): 59 - 61. 10.4274/vhd.galenos.2019.2019.0011 |
| MLA | Kaya Selçuk,AFŞAR İlhan,AKSOY GÖKMEN AYŞEGÜL,sener asli gamze,SAYINER AYCA ARZU Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital. , 2019, ss.59 - 61. 10.4274/vhd.galenos.2019.2019.0011 |
| AMA | Kaya S,AFŞAR İ,AKSOY GÖKMEN A,sener a,SAYINER A Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital. . 2019; 59 - 61. 10.4274/vhd.galenos.2019.2019.0011 |
| Vancouver | Kaya S,AFŞAR İ,AKSOY GÖKMEN A,sener a,SAYINER A Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital. . 2019; 59 - 61. 10.4274/vhd.galenos.2019.2019.0011 |
| IEEE | Kaya S,AFŞAR İ,AKSOY GÖKMEN A,sener a,SAYINER A "Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital." , ss.59 - 61, 2019. 10.4274/vhd.galenos.2019.2019.0011 |
| ISNAD | Kaya, Selçuk vd. "Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital". (2019), 59-61. https://doi.org/10.4274/vhd.galenos.2019.2019.0011 |
| APA | Kaya S, AFŞAR İ, AKSOY GÖKMEN A, sener a, SAYINER A (2019). Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital. Viral Hepatitis Journal, 25(2), 59 - 61. 10.4274/vhd.galenos.2019.2019.0011 |
| Chicago | Kaya Selçuk,AFŞAR İlhan,AKSOY GÖKMEN AYŞEGÜL,sener asli gamze,SAYINER AYCA ARZU Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital. Viral Hepatitis Journal 25, no.2 (2019): 59 - 61. 10.4274/vhd.galenos.2019.2019.0011 |
| MLA | Kaya Selçuk,AFŞAR İlhan,AKSOY GÖKMEN AYŞEGÜL,sener asli gamze,SAYINER AYCA ARZU Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital. Viral Hepatitis Journal, vol.25, no.2, 2019, ss.59 - 61. 10.4274/vhd.galenos.2019.2019.0011 |
| AMA | Kaya S,AFŞAR İ,AKSOY GÖKMEN A,sener a,SAYINER A Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital. Viral Hepatitis Journal. 2019; 25(2): 59 - 61. 10.4274/vhd.galenos.2019.2019.0011 |
| Vancouver | Kaya S,AFŞAR İ,AKSOY GÖKMEN A,sener a,SAYINER A Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital. Viral Hepatitis Journal. 2019; 25(2): 59 - 61. 10.4274/vhd.galenos.2019.2019.0011 |
| IEEE | Kaya S,AFŞAR İ,AKSOY GÖKMEN A,sener a,SAYINER A "Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital." Viral Hepatitis Journal, 25, ss.59 - 61, 2019. 10.4274/vhd.galenos.2019.2019.0011 |
| ISNAD | Kaya, Selçuk vd. "Evaluation of Hepatitis C Virus Genotype Results in İzmir Atatürk Training and Research Hospital". Viral Hepatitis Journal 25/2 (2019), 59-61. https://doi.org/10.4274/vhd.galenos.2019.2019.0011 |
