Purpose: The study was carried out to determine whether occupational health and safety in order to determine their opinions on job satisfaction. Materials and Methods: This descriptive study was conducted at the a University Hospital between April 2015 and March 2016 . The study was completed with 195 people. The data were collected by demographic form, Occupational Safety Scale in Hospitals and Minnesota Job Satisfaction Scale. Findings: 53.8% of the health personnel are nurses, 39.5% are physicians, 6.2% are other healthcare personnel and the average age is 28.33±6.17. The total score of the work safety scale (1.67 ± 0.76) in hospitals was not ensured in all health personnel hospitals, while occupational disease and complaints (2.12 ± 0.95) were defined as insufficient work safety in the sub-dimension, while medium-level work safety was stated in the physical environment appropriateness (3.07 ± 1.15) dimension. Conclusion:While general job satisfaction of the health personnel (2.66±0.88) and internal satisfaction score (2.67±0.90) were close to the neutral satisfaction score, the external satisfaction score (2.08 ±0.66) was found to be low. It was found that there was a significant relationship between occupational health and safety and job satisfaction of different group of health personnel.