Yıl: 2022 Cilt: 54 Sayı: 1 Sayfa Aralığı: 62 - 65 Metin Dili: İngilizce DOI: 10.5152/eurasianjmed.2022.22293 İndeks Tarihi: 24-05-2023

An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response

Öz:
Ischemia–reperfusion is a common health problem leading to several health conditions. The pathophysiology of ischemia–reperfusion is quite complex. Oxidative stress and inflammatory response contribute to ischemia– reperfusion mechanisms. Various parameters like proinflammatory cytokines, reactive oxygen species, occur during ischemia–reperfusion . There are several ways to investigate these values through biochemical and histopathologic findings. Malondialdehyde, glutathione, myeloperoxidase, superoxide dismutase, interleukin 6, interleukin 1β, tumor necrosis factor alpha, caspase-3, nuclear factor-kappa β, and LC3B (micr otubu le-as socia ted protein light chain 3, LC3) can be evaluated among these indicators.
Anahtar Kelime:

Belge Türü: Makale Makale Türü: Derleme Erişim Türü: Erişime Açık
  • 1. Kalogeris T, Baines CP, Krenz M, Korthuis RJ. Cell biology of ischemia/reperfusion injury. Int Rev Cell Mol Biol. 2012;298:229-317. [CrossRef]
  • 2. Sheridan AM, Bonventre JV. Pathophysiology of ischemic acute renal failure. Contrib Nephrol. 2001;(132):7-21. [CrossRef]
  • 3. Ahmed N. Introduction to ischemia–reperfusion injury. Pathophysiol Ischemia Reperfusion Inj Use Fingolimod Cardioprotection. 2019:1-39. [CrossRef]
  • 4. Devarajan P. Update on mechanisms of ischemic acute kidney injury. J Am Soc Nephrol. 2006;17(6):1503-1520. [CrossRef]
  • 5. Yellon DM, Hausenloy DJ. Myocardial reperfusion injury. N Engl J Med. 2007;357(11):1121- 1135. [CrossRef]
  • 6. Zhao ZQ, Nakamura M, Wang NP, et al. Dynamic progression of contractile and endothelial dysfunction and infarct extension in the late phase of reperfusion. J Surg Res. 2000;94(2):133-144. [CrossRef]
  • 7. Li J, Rogers NM, Hawthorne WJ. Ischemia-reperfusion injury. Organ Repair Regen Preserving Organs Regen Med Era. 2021:1-42. [CrossRef]
  • 8. Kula-Alwar D, Prag HA, Krieg T. Targeting succinate metabolism in ischemia/reperfusion injury. Circulation. 2019;140(24):1968-1970. [CrossRef]
  • 9. Ali M, Pham A, Wang X, Wolfram J, Pham S. Extracellular vesicles for treatment of solid organ ischemia–reperfusion injury. Am J Transplant. 2020;20(12):3294-3307. [CrossRef]
  • 10. Tang J, Zhuang S. Histone acetylation and DNA methylation in ischemia/reperfusion injury. Clin Sci (Lond). 2019;133(4):597-609. [CrossRef]
  • 11. Al-Jaghbeer M, Dealmeida D, Bilderback A, Ambrosino R, Kellum JA. Clinical decision support for In-Hospital AKI. J Am Soc Nephrol. 2018;29(2):654-660. [CrossRef]
  • 12. Bulkley GB. Free radical-mediated reperfusion injury: a selective review. Br J Cancer Suppl. 1987;8(8):66-73.
  • 13. Rabbani N, Thornalley PJ. Hexokinase-2 glycolytic overload in diabetes and ischemia–reperfusion injury. Trends Endocrinol Metab. 2019; 30(7):419-431. [CrossRef]
  • 14. Al-Taie A, Sancar M, Izzettin FV. 8-hyd roxyd eoxyg uanos ine: a valuable predictor of oxidative DNA damage in cancer and diabetes mellitus. Cancer Oxid Stress Diet Antioxid. 2021:179-187. [CrossRef]
  • 15. Nishikawa T, F Sato E, Choudhury T, et al. Effect of nitric oxide on the oxygen metabolism and growth of E. faecalis. J Clin Biochem Nutr. 2009;44(2):178-184. [CrossRef]
  • 16. Bardaweel SK, Gul M, Alzweiri M, Ishaqat A, ALSalamat HA, Bashatwah RM. Reactive oxygen species: the dual role in physiological and pathological conditions of the human body. Eurasian J Med. 2018;50(3):193-201. [CrossRef]
  • 17. Ray PD, Huang BW, Tsuji Y. Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling. Cell Signal. 2012;24(5):981-990. [CrossRef]
  • 18. Griendling KK, Touyz RM, Zweier JL, et al. Measurement of reactive oxygen species, reactive nitrogen species, and redox-dependent signaling in the cardiovascular system: a Scientific Statement From the American Heart Association. Circ Res. 2016;119(5):e39-e75. [CrossRef]
  • 19. Ferah Okkay I, Okkay U, Cicek B, et al. Neuroprotective effect of bromelain in 6-hydroxydopamine induced in vitro model of Parkinson’s disease. Mol Biol Rep. 2021;48(12):7711-7717. [CrossRef]
  • 20. Aruoma OI. Nutrition and health aspects of free radicals and antioxidants. Food Chem Toxicol. 1994;32(7):671-683. [CrossRef]
  • 21. Cheeseman KH, Slater TF. An introduction to free radical biochemistry. Br Med Bull. 1993;49(3):481-493. [CrossRef]
  • 22. Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy- 2-nonenal. Oxid Med Cell Longev. 2014;2014: 360438. [CrossRef]
  • 23. Weismann D, Hartvigsen K, Lauer N, et al. Complement factor H binds malondialdehyde epitopes and protects from oxidative stress. Nature. 2011;478(7367):76-81. [CrossRef]
  • 24. Tanyeli A, Nur F, Akdemir E. The possible useful effectiveness of sinapic acid sepsis-induced secondary organ damage in rats. Clin Exp Health Sci. 2022;12(1):134-140. [CrossRef]
  • 25. Klebanoff SJ. Myeloperoxidase: friend and foe. J Leukoc Biol. 2005;77(5):598-625. [CrossRef]
  • 26. Schultz J, Kaminker K. Myeloperoxidase of the leucocyte of normal human blood. I. Content and localization. Arch Biochem Biophys. 1962;96(3):465-467. [CrossRef]
  • 27. Eraslan E, Tanyeli A, Polat E, Polat E. 8-Br-cADPR, a TRPM2 ion channel antagonist, inhibits renal ischemia-reperfusion injury. J Cell Physiol. 2019;234(4):4572-4581. [CrossRef]
  • 28. Brennan ML, Hazen SL. Emerging role of myeloperoxidase and oxidant stress markers in cardiovascular risk assessment. Curr Opin Lipidol. 2003;14(4):353-359. [CrossRef]
  • 29. Linas SL, Shanley PF, Whittenburg D, Berger E, Repine JE. Neutrophils accentuate ischemiareperfusion injury in isolated perfused rat kidneys. Am J Physiol. 1988;255(4 Pt 2):F728-F735. [CrossRef]
  • 30. Topdağı Ö, Tanyeli A, Akdemir FNE, Eraslan E, Güler MC, Çomaklı S. Preventive effects of fraxin on ische mia/r eperf usion -indu ced acute kidney injury in rats. Life Sci. 2020;242:117217. [CrossRef]
  • 31. Güler MC, Tanyeli A, Eraslan E, Ekinci Akdemir FN. Role of 6-shogaol against ovarian torsion detorsion-induced reproductive organ damage. New Trend Med Sci. 2020;1(1):29-34.
  • 32. Tanyeli A, Guzel Erdogan D, Comakli S, et al. Therapeutic effects of apocynin on ovarian ischemia-reperfusion induced lung injury. Biotech Histochem. 2022;97(7):536-545. [CrossRef]
  • 33. Güler MC, Tanyeli A, Erdoğan DG, et al. Urapidil alleviates ovarian torsion detorsion injury via regulating oxidative stress, apoptosis, autophagia, and inflammation. Iran J Basic Med Sci. 2021;24(7):935-942. [CrossRef]
  • 34. Pomarede N, Chandramouli M. Enhancing the skin's natural antioxidant enzyme system by the supplementation or upregulation of superoxide dismutase, catalase, and glutathione peroxidase. Nutr Cosmet. 2009:245-265. [CrossRef]
  • 35. Alanazi AM, Mostafa GAE, Al-Badr AA. Glutathione. Profiles Drug Subst Excipients Relat Methodol. 2015;40:43-158. [CrossRef]
  • 36. Liu Y, Hyde AS, Simpson MA, Barycki JJ. Emerging regulatory paradigms in glutathione metabolism. Adv Cancer Res. 2014;122:69-101. [CrossRef]
  • 37. Güzel Erdoğan D, Tanyeli A, Güler MC, Eraslan E, Çomaklı S, Doğanay S. Beneficial Effects of Urapidil against Renal Ischemia Reperfusion- Related Renal Injury. 2022;33(2):198-202. [CrossRef]
  • 38. Ekinci Akdemir FN, Tanyeli A, Güler MC, Eraslan E, Yiımaz Topdağı EP, Topdaği YE. Brusatol mitigates ovarian tissue Oxidatif injury induced by ovarian ischemia reperfusion. Akd Tıp D. 2021;7(2):206-211. [CrossRef]
  • 39. Kvietys PR, Granger DN. Role of reactive oxygen and nitrogen species in the vascular responses to inflammation. Free Radic Biol Med. 2012;52(3):556- 592. [CrossRef]
  • 40. Georgiades F, Hosgood SA, Nicholson ML. Assessing and reconditioning kidneys using normothermic machine perfusion. Organ Repair Regen Preserving Organs Regen Med Era. 2021:75- 93. [CrossRef]
  • 41. Carswell EA, Old LJ, Kassel RL, Green S, Fiore N, Williamson B. An endotoxin induced serum factor that cuases necrosis of tumors. Proc Natl Acad Sci U S A. 1975;72(9):3666-3670. [CrossRef]
  • 42. Bertazza L, Mocellin S. Tumor necrosis factor (TNF) biology and cell death. Front Biosci. 2008;13(7):2736-2743. [CrossRef]
  • 43. Bradley JR. TNF-mediated inflammatory disease. J Pathol. 2008;214(2):149-160. [CrossRef]
  • 44. Breder CD, Tsujimoto M, Terano Y, Scott DW, Saper CB. Distribution and characterization of tumor necrosis factor-alpha-like immunoreactivity in the murine central nervous system. J Comp Neurol. 1993;337(4):543-567. [CrossRef]
  • 45. Inoue Ji, Ishida T, Tsukamoto N, et al. Tumor necrosis factor receptor-associated factor (TRAF) family: adapter proteins that mediate cytokine signaling. Exp Cell Res. 2000;254(1):14- 24. [CrossRef]
  • 46. Bonventre JV, Yang L. Cellular pathophysiology of ischemic acute kidney injury. J Clin Invest. 2011;121(11):4210-4221. [CrossRef]
  • 47. Atkins E, Wood WB. Studies on the pathogenesis of fever. I. The presence of transferable pyrogen in the blood stream following the injection of typhoid vaccine. J Exp Med. 1955;101(5):519-528. [CrossRef]
  • 48. Brough D, Rothwell NJ. Caspase-1-dependent processing of pro-i nterl eukin -1bet a is cytosolic and precedes cell death. J Cell Sci. 2007;120(5):772- 781. [CrossRef]
  • 49. Okamoto M, Liu W, Luo Y, et al. Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1β. J Biol Chem. 2010;285(9):6477-6488. [CrossRef]
  • 50. Jewett KA, Krueger JM. Humoral sleep regulation; interleukin-1 and tumor necrosis factor. Vitam Horm. 2012;89:241-257. [CrossRef]
  • 51. Brandwein SR. Regulation of interleukin 1 production by mouse peritoneal macrophages. Effects of arachidonic acid metabolites, cyclic nucleotides, and interferons. J Biol Chem. 1986;261(19):8624-8632. [CrossRef]
  • 52. Churchill L, Taishi P, Wang M, et al. Brain distribution of cytokine mRNA induced by systemic administration of interleukin-1beta or tumor necrosis factor alpha. Brain Res. 2006;1120(1):64- 73. [CrossRef]
  • 53. Church LD, Cook GP, McDermott MF. Primer: inflammasomes and interleukin 1beta in inflammatory disorders. Nat Clin Pract Rheumatol. 2008;4(1):34-42. [CrossRef]
  • 54. Dinarello CA. Proinflammatory cytokines. Chest. 2000;118(2):503-508. [CrossRef]
  • 55. Eltzschig HK, Collard CD. Vascular ischaemia and reperfusion injury. Br Med Bull. 2004;70:71-86. [CrossRef]
  • 56. Dembic Z. Cytokines of the immune system: interleukins. The Cytokines of the Immune System. 2015:143-239. [CrossRef]
  • 57. Kumar H, Kawai T, Akira S. Pathogen recognition by the innate immune system. Int Rev Immunol. 2011;30(1):16-34. [CrossRef]
  • 58. Tanaka T, Narazaki M, Kishimoto T. Anti-interleukin- 6 receptor antibody therapy against autoimmune inflammatory diseases. Mol Biol B Cells. 2015:515-525. [CrossRef]
  • 59. Topdagi O, Tanyeli A, Ekinci Akdemir FN. Casticin mitigates renal damage injured by ischemia reperfusion: a biochemical study. JAMP. 2021; 3(3):245-248. [CrossRef]
  • 60. Eraslan E, Bircan B, Tanyeli A, Can Güler MC, Bayır Y, Altun S. SCM-198 can regulate autophagy through the Bax/Bcl-2/TLR4 pathway to alleviate renal ischemia-reperfusion injury. EuroBiotech Journal. 2021;5(4):161-169. [CrossRef]
  • 61. Güler MC, Tanyeli A. Role of hyperoside on ovarian tissue damage created by ovarian torsion detorsion. New Trend Med Sci. 2020;1(1):1-5.
  • 62. Güler MC, Tanyeli A, Eraslan E, Ekinci Akdemir FN, Nacar T, Topdaği Ö. Higenamine decreased oxidative kidney damage induced by ischemia reperfusion in rats. Kafkas Univ Vet Fak Derg. 2020;26(3):365-370. [CrossRef]
  • 63. Tanyeli A, Eraslan E, Güler MC, Kurt N, Akaras N. Gossypin protects against renal ischemia- reperfusion injury in rats. Kafkas Univ Vet Fak Derg. 2020;26(1):89-96. [CrossRef]
  • 64. Adcock IM, Ford P, Ito K, Barnes PJ. Epigenetics and airways disease. Respir Res. 2006;7(1):21. [CrossRef]
  • 65. Imai Y, Kuba K, Neely GG, et al. Identification of oxidative stress and toll-like receptor 4 signaling as a key pathway of acute lung injury. Cell. 2008;133(2):235-249. [CrossRef]
  • 66. Çakır M, Tekin S, Doğanyiğit Z, Çakan P, Kaymak E. The protective effect of cannabinoid type 2 receptor activation on renal ischemia–reperfusion injury. Mol Cell Biochem. 2019;462(1-2):123- 132. [CrossRef]
  • 67. Tao Y, Chen YC, Lan T, Qian H, Wang Y, Jiang L. LPS-induced nuclear translocation of RhoA is dependent on NF-κB in the human lung cancer cell line A549. Oncol Lett. 2012;3(6):1283-1287. [CrossRef]
  • 68. Un H, Ugan RA, Kose D, et al. A new approach to sepsis treatment by rasagiline: a molecular, biochemical and histopathological study. Mol Biol Rep. 2022;49(5):3875-3883. [CrossRef]
  • 69. Un H, Ugan RA, Kose D, et al. A novel effect of aprepitant: protection for cisplatin-induced nephrotoxicity and hepatotoxicity. Eur J Pharmacol. 2020;880:173168. [CrossRef]
  • 70. Kroemer G, Galluzzi L, Vandenabeele P, et al. Classification of cell death: recommendations of the Nomenclature Committee on Cell Death 2009. Cell Death Differ. 2009;16(1):3-11. [CrossRef]
  • 71. Isobe I, Onodera H. Role of immunohistochemical expression of caspase-3 in Gastric Carcinoma. Handbook of Immunohistochemistry and in Situ Hybridization of Human Carcinomas. 2006;4:247-250. [CrossRef]
  • 72. Alnemri ES, Livingston DJ, Nicholson DW, et al. Human ICE/CED-3 protease nomenclature. Cell. 1996;87(2):171-171. [CrossRef]
  • 73. Shalini S, Dorstyn L, Dawar S, Kumar S. Old, new and emerging functions of caspases. Cell Death Differ. 2015;22(4):526-539. [CrossRef]
  • 74. Walters J, Pop C, Scott FL, et al. A constitutively active and uninhibitable caspase-3 zymogen efficiently induces apoptosis. Biochem J. 2009;424(3):335-345. [CrossRef]
  • 75. He C, Klionsky DJ. Regulation mechanisms and signaling pathways of autophagy. Annu Rev Genet. 2009;43:67-93. [CrossRef]
  • 76. Galluzzi L, Vitale I, Aaronson SA, et al. Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018. Cell Death Differ. 2018;25(3):486-541. [CrossRef]
  • 77. He Y, Zhao X, Subahan NR, Fan L, Gao J, Chen H. The prognostic value of autophagyrelated markers beclin-1 and micro tubul e-ass ociat ed protein light chain 3B in cancers: a systematic review and meta-analysis. Tumour Biol. 2014;35(8):7317-7326. [CrossRef]
  • 78. Lazova R, Camp RL, Klump V, Siddiqui SF, Amaravadi RK, Pawelek JM. Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome. Clin Cancer Res. 2012;18(2):370-379. [CrossRef]
APA guler m, tanyeli a, Ekinci Akdemir F, Eraslan E, OZBEK SEBIN S, Güzel Erdoğan D, NACAR T (2022). An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response. , 62 - 65. 10.5152/eurasianjmed.2022.22293
Chicago guler mustafa can,tanyeli ayhan,Ekinci Akdemir Fazile Nur,Eraslan Ersen,OZBEK SEBIN SAIME,Güzel Erdoğan Derya,NACAR TUNCER An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response. (2022): 62 - 65. 10.5152/eurasianjmed.2022.22293
MLA guler mustafa can,tanyeli ayhan,Ekinci Akdemir Fazile Nur,Eraslan Ersen,OZBEK SEBIN SAIME,Güzel Erdoğan Derya,NACAR TUNCER An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response. , 2022, ss.62 - 65. 10.5152/eurasianjmed.2022.22293
AMA guler m,tanyeli a,Ekinci Akdemir F,Eraslan E,OZBEK SEBIN S,Güzel Erdoğan D,NACAR T An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response. . 2022; 62 - 65. 10.5152/eurasianjmed.2022.22293
Vancouver guler m,tanyeli a,Ekinci Akdemir F,Eraslan E,OZBEK SEBIN S,Güzel Erdoğan D,NACAR T An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response. . 2022; 62 - 65. 10.5152/eurasianjmed.2022.22293
IEEE guler m,tanyeli a,Ekinci Akdemir F,Eraslan E,OZBEK SEBIN S,Güzel Erdoğan D,NACAR T "An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response." , ss.62 - 65, 2022. 10.5152/eurasianjmed.2022.22293
ISNAD guler, mustafa can vd. "An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response". (2022), 62-65. https://doi.org/10.5152/eurasianjmed.2022.22293
APA guler m, tanyeli a, Ekinci Akdemir F, Eraslan E, OZBEK SEBIN S, Güzel Erdoğan D, NACAR T (2022). An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response. Eurasian Journal of Medicine, 54(1), 62 - 65. 10.5152/eurasianjmed.2022.22293
Chicago guler mustafa can,tanyeli ayhan,Ekinci Akdemir Fazile Nur,Eraslan Ersen,OZBEK SEBIN SAIME,Güzel Erdoğan Derya,NACAR TUNCER An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response. Eurasian Journal of Medicine 54, no.1 (2022): 62 - 65. 10.5152/eurasianjmed.2022.22293
MLA guler mustafa can,tanyeli ayhan,Ekinci Akdemir Fazile Nur,Eraslan Ersen,OZBEK SEBIN SAIME,Güzel Erdoğan Derya,NACAR TUNCER An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response. Eurasian Journal of Medicine, vol.54, no.1, 2022, ss.62 - 65. 10.5152/eurasianjmed.2022.22293
AMA guler m,tanyeli a,Ekinci Akdemir F,Eraslan E,OZBEK SEBIN S,Güzel Erdoğan D,NACAR T An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response. Eurasian Journal of Medicine. 2022; 54(1): 62 - 65. 10.5152/eurasianjmed.2022.22293
Vancouver guler m,tanyeli a,Ekinci Akdemir F,Eraslan E,OZBEK SEBIN S,Güzel Erdoğan D,NACAR T An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response. Eurasian Journal of Medicine. 2022; 54(1): 62 - 65. 10.5152/eurasianjmed.2022.22293
IEEE guler m,tanyeli a,Ekinci Akdemir F,Eraslan E,OZBEK SEBIN S,Güzel Erdoğan D,NACAR T "An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response." Eurasian Journal of Medicine, 54, ss.62 - 65, 2022. 10.5152/eurasianjmed.2022.22293
ISNAD guler, mustafa can vd. "An Overview of Ischemia–Reperfusion Injury: Review on Oxidative Stress and Inflammatory Response". Eurasian Journal of Medicine 54/1 (2022), 62-65. https://doi.org/10.5152/eurasianjmed.2022.22293