Objective: This study was conducted to determine the levels of e-health literacy and healthy lifestyle behaviors of adolescents. Method: The study population of this descriptive study consisted of 17722 high school students who were educated in Balıkesir province in 2016-2017 and 553 students who accepted to participate in the research were reached. Data were collected through Personal Information Form, e-Health Literacy Scale and Healthy Life Style Behavior Scale. Percentile, t-test and variance analysis were used in the analysis of the data. Results: More than half (55.5%) of the students included in the survey were in the group of 16 years old and over, and 53.5% of them were male students. While 40.1% of the students indicated that they were using internet more than 3 hours a day, and 57.3% of them stated that they were using internet with the intention to chat, and for social communication The 46.5% of the respondents (39.4, and 7.1%, respectively) said that access to health resources on internet was important/very important. The e-health literacy mean score of the students was 25.98±0.27 and the mean score of healthy lifestyle behaviors was 127.26±0.93. According to the opinions of the respondents concerning access to health resources on the internet within the last week, the usefulness of internet on deciding about their health state, importance of accessing health resources on the internet, a statistically significant difference was detected between healthy lifestyle behaviors and e-health literacy scores. It has been found that average skill scores of e-health literacy and healthy lifestyle behaviors were higher in the adolescents who gained access into health resources on the internet within the previous week, and thought that internet was helpful/ very helpful in deciding about health issues, and accessing health resources on the internet was important/very important. Conclusion: At the end of the study, it was determined that mean scores for e-health literacy and healthy lifestyle behaviors were slightly higher than middle level but not at high level in adolescents.