Determining the depressive symptom levels and related factors of medical students and preventing emotional stress in students will contribute to the training of healthy physicians who may be more beneficial to the society. The aim of the study is to evaluate the depressive symptom status and the factors that may be related of the first and last year students of Erciyes University Faculty of Medicine. This cross-sectional study was conducted with first and sixth grade students at Erciyes University Faculty of Medicine in the 2017-2018 academic year. The study was completed with the participation of 467 (71.4%) out of a total of 654 students studying in these two years. Data collection tools consist of a questionnaire form consisting of 33 questions about students' sociodemographic characteristics such as age, gender, place of residence, economic status, health status, school life, physical activity, diet and other habits, and the Beck Depression Scale (BDI).Chi Square, Mann Whitney U, Kruskall Wallis tests and regression analysis were used in the statistical analysis of the data. The average age of the students is 21.8 ± 3.2 (min-max: 18-40) years, 53.3% are first class and 51% are women, and 75.6% of their families live in the city center. The scale score average of the students is 10.4 ± 8.3 (min-max: 0-63) and the frequency of depressive symptoms is 22.7% for all students, 21.3% for first year students and 24.3% for senior students. While there was no difference between the scale scores of the students according to their class, gender, and family place, the frequency of depressive symptoms was found to be higher in students from East-Southeastern regions, who have a smoking habit, do not do regular physical activity, are not satisfied with their school, and have not good relations with their families and friends. BDI scores are higher in students who do not have regular breakfast, lunch and dinner, and who have eating crises and regret after eating. The frequency of depressive symptoms was found to be high in the first and last year students of the Faculty of Medicine. Providing counseling to smoking students on quitting smoking, conducting awareness studies in classes and other social areas to encourage physical activity and regular nutrition, and developing communication skills can bring positive results.