In the period until and after the history of humanity found money, the hiding, evaluation and exchange processes of certain values constituted the economic life of people throughout history. The invention of money and the increase in human interactions required the existence of institutions that regulate economic events. Banks born out of this need have started to ensure that individuals and institutions perform their financial transactions in a regular way. Banks, which expanded their job definition over time, started to provide many services to individuals and institutions. Competition of financial institutions and banks that increased over time led banks to take actions to increase their profitability. In this context, the main purpose of the study is to determine the variables that affect the profitability of the 24 banks in the Turkish Banking Sector between the years 2009-2018 after the 2008 Global Financial Crisis. According to the findings reached in the study using panel data regression method; It has been observed that the variables such as capital ratio, liquidity risk, level of lending, bank size and concentration give statistically significant results in explaining the change in performance.